PROKR2 Cancer Research Results

PROKR2, Prokineticin Receptor 2; PKR2 ,GPR73B: Click to Expand ⟱
Source:
Type:

PROKR2 (Prokineticin Receptor 2; PKR2) — Seven-transmembrane G-protein-coupled receptor for prokineticins, particularly PROK2. PROKR2 regulates intracellular signaling involved in neuronal development, circadian biology, migration, angiogenesis, calcium signaling, and other cellular responses.

Typical modulation in cancer: Context-dependent. Activation of the PROK2–PROKR2 axis can promote angiogenic, migratory, inflammatory, and tumor-supporting signaling in selected cancers, although effects depend strongly on tissue and cellular context.

Typical modulation in Alzheimer’s disease: No established universal direction. PROKR2 has substantial neurological and circadian relevance but is not currently a core AD target.
Scientific Papers found: Click to Expand⟱
8556- Matr,    Matrine alleviates spatial learning and memory impairment in diabetic mice by inhibiting endoplasmic reticulum stress and through modulation of PK2/PKRs pathway
- in-vivo, AD, NA - in-vivo, Diabetic, NA
*AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *glucose↓, *Learn↑, *memory↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *ATF6↓, *Casp12↓, *PROK2↑, *PROKR1↑, *PROKR2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,  

Cell Death(tgid=5) ⓘ

Casp12↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

PROKR1↑, 1,   PROKR2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,  

Migration(tgid=13) ⓘ

PROK2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   Learn↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: PROKR2, Prokineticin Receptor 2; PKR2 ,GPR73B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1866  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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