THBD Cancer Research Results

THBD, CD141, Thrombomodulin: Click to Expand ⟱
Source:
Type:

THBD (Thrombomodulin; CD141) — Endothelial cell-surface glycoprotein receptor that binds thrombin and alters its substrate specificity, promoting activation of protein C. Activated protein C subsequently inactivates coagulation factors Va and VIIIa, reducing further thrombin generation. THBD also contributes to endothelial protection and regulation of inflammatory and coagulation pathways.

Typical modulation in cancer: Context-dependent. Loss or reduction of endothelial or tumor-cell THBD can be associated with increased coagulation, inflammation, invasion, and poorer prognosis in some cancers, whereas preserved or increased THBD may reflect a more differentiated or less aggressive phenotype. Effects vary substantially by tumor type.

Typical modulation in Alzheimer’s disease: No established core Alzheimer’s disease-specific direction. THBD may have indirect relevance through endothelial dysfunction, vascular inflammation, coagulation, and blood-brain barrier-related mechanisms.
Scientific Papers found: Click to Expand⟱
8728- M-Blu,    Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue
- Review, AD, NA
*Dose↝, *antiOx↑, *mitResp↑, *neuroP↑, *memory↑, *CellMemb↑, *BBB↑, *other↝, *compV↑, *OCR↑, *ROS↓, *Sepsis↓, *NO↓, *RNS↓, *memory↑, *tau↓, *CX43/GJA1↑, *THBD↑, *CARTPT↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   RNS↓, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compV↑, 1,   mitResp↑, 1,   OCR↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   CX43/GJA1↑, 1,   THBD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

CARTPT↑, 1,  

Protein Aggregation(tgid=19) ⓘ

tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 2,   neuroP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 18

Scientific Paper Hit Count for: THBD, CD141, Thrombomodulin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1888  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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