NR1H4 Cancer Research Results

NR1H4, FXR, NR1H4 Nuclear Receptor Subfamily 1 Group H Member 4; Farnesoid X Receptor: Click to Expand ⟱
Source:
Type:

NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4; Farnesoid X Receptor, FXR) — Ligand-activated nuclear receptor and transcription factor that functions primarily as a bile-acid sensor. FXR regulates bile-acid synthesis and transport, cholesterol homeostasis, lipid and glucose metabolism, enterohepatic signaling, inflammation, and hepatic metabolic gene expression.

Typical modulation in cancer: Context-dependent. FXR can function as a tumor suppressor in some gastrointestinal and hepatic cancers by limiting inflammation, bile-acid toxicity, and proliferative signaling, whereas FXR activation may support survival or metabolic adaptation in selected tumor contexts. A universal ↑ or ↓ cancer direction should therefore not be assigned.

Typical mechanistic relationships: Bile acids → FXR activation → transcriptional regulation of genes involved in bile-acid synthesis/transport, cholesterol metabolism, lipid metabolism, and inflammatory signaling.

abbreviations: NR1H4; common name: FXR; aliases include BAR, RIP14, HRR1.
Scientific Papers found: Click to Expand⟱
8883- MOR,  5-FU,    Morin Mitigates 5-Fluorouracil-Induced Nephrotoxicity by Activating Nrf2/HO-1 and FXR, and Suppressing ERK/VCAM-1 and NF-κB Pathways
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *Dose↝, *Urea↓, *creat↓, *ROS↓, *NRF2↑, *HO-1↑, *NR1H4↑, *RenoP↑, *TNF-α↓, *IL6↓, *ERK↓, *VCAM-1↓, *NF-kB↓, *chemoP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VCAM-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

NR1H4↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

creat↓, 1,   IL6↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   RenoP↑, 1,  
Total Targets: 17

Scientific Paper Hit Count for: NR1H4, FXR, NR1H4 Nuclear Receptor Subfamily 1 Group H Member 4; Farnesoid X Receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1901  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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