Uridine Cancer Research Results

Uridine, Uridine: Click to Expand ⟱

Source:

Type:

Uridine — Naturally occurring pyrimidine nucleoside composed of uracil linked to ribose. Uridine is an important intermediate in pyrimidine metabolism and contributes to RNA synthesis, nucleotide salvage, UDP-sugar formation, glycogen metabolism, membrane phospholipid synthesis, and cellular metabolic regulation.

Typical modulation in cancer: Context-dependent. Uridine can support nucleotide availability and cell proliferation through pyrimidine salvage pathways. Inhibition of de novo pyrimidine synthesis can increase dependence on extracellular uridine, whereas uridine supplementation can rescue cells from selected pyrimidine-synthesis inhibitors. Uridine may also reduce toxicity from some fluoropyrimidine drugs, so direction should be interpreted according to experimental context.

Typical modulation in Alzheimer’s disease / neurodegeneration: Potentially beneficial in selected contexts. Uridine provides precursors for neuronal membrane phospholipid synthesis and has been investigated together with choline and omega-3 fatty acids for supporting synapse formation and neuronal membrane metabolism.

Typical mechanistic relationships: Uridine → UMP → UDP/UTP → RNA synthesis and UDP-dependent biosynthetic pathways. Uridine also contributes indirectly to CTP formation and phosphatidylcholine synthesis through the Kennedy pathway.

Scientific Papers found: Click to Expand⟱

8990-

Citicoline,

Effect of oral CDP-choline on plasma choline and uridine levels in humans

Trial,

Nor,

Twelve mildly hypertensive but otherwise normal fasting subjects received each of four treatments in random order: CDP-choline (citicoline; 500, 2000, and 4000 mg) or a placebo orally at 8:00 a.m. on four different treatment days.

*Dose?, *Uridine↑, *other↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis(tgid=4) ⓘ

Uridine↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,
Total Targets: 3

Scientific Paper Hit Count for: Uridine, Uridine

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells