PDE Cancer Research Results

PDE, Phosphodiesters: Click to Expand ⟱

Source:

Type:

Phosphodiesters (PDE) — Group of phosphorus-containing metabolites detectable by 31P magnetic resonance spectroscopy, particularly glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE), that reflect membrane phospholipid degradation, remodeling, synthesis, and turnover.

Typical interpretation: Context-dependent. Changes in phosphodiester levels can reflect altered membrane phospholipid turnover rather than a simple increase or decrease in membrane phospholipid abundance.

Citicoline relevance: In healthy older adults given citicoline 500 mg/day for 6 weeks, brain phosphodiesters increased by 7.3%, including an 11.6% increase in glycerophosphoethanolamine and a 5.1% increase in glycerophosphocholine. The authors interpreted these changes as evidence of increased phospholipid synthesis and turnover.

Typical components: Glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE).

Scientific Papers found: Click to Expand⟱

8991-

Citicoline,

Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study

Human,

Nor,

*PDE↑, *Dose?, *Learn↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis(tgid=4) ⓘ

PDE↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,

Functional Outcomes(tgid=23) ⓘ

Learn↑, 1,
Total Targets: 3

Scientific Paper Hit Count for: PDE, Phosphodiesters

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells