NPAS4 Cancer Research Results

NPAS4, : Click to Expand ⟱
Source:
Type:

NPAS4 (Neuronal PAS Domain Protein 4) — Activity-dependent basic helix-loop-helix PAS-family transcription factor and immediate-early gene expressed predominantly in neurons. NPAS4 links neuronal activity and intracellular Ca2+ signaling to transcriptional programs controlling synaptic plasticity, excitatory-inhibitory balance, memory formation, and neuronal survival.

Typical modulation in Alzheimer’s disease / neurodegeneration: Generally protective when appropriately activated. NPAS4 supports neuronal survival, synaptic homeostasis, and plasticity. Experimental NPAS4 overexpression has also been reported to enhance autophagic clearance of total and phosphorylated tau, suggesting potential relevance to Alzheimer’s disease and other tauopathies.

Typical mechanistic relationships: Neuronal activity / Ca2+ influx → NPAS4 ↑ → activity-dependent gene transcription → BDNF and other synaptic genes ↑ → inhibitory/excitatory synaptic remodeling and circuit homeostasis. NPAS4 can heterodimerize with ARNT or ARNT2 to regulate transcription.

Tau relevance: NPAS4 ↑ → autophagy ↑ → total and phosphorylated tau clearance ↑ in experimental neuronal models.
Scientific Papers found: Click to Expand⟱
9070- L-THE,    Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses
- in-vivo, Nor, NA
*BrainVol↑, *NPAS4↑, *Lcn2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

Lcn2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BrainVol↑, 1,   NPAS4↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: NPAS4, 
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1917  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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