ATP Cancer Research Results

ATP, Adenosine triphosphate: Click to Expand ⟱
Source:
Type:
Adenosine triphosphate (ATP) is the source of energy for use and storage at the cellular level.
Cellular ATP levels are critical for cell survival, and several reports have shown that reductions in cellular ATP levels can lead to apoptosis and other types of cell death in cancer cells, depending on the level of depletion.
Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells.

Cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the “Warburg effect”, and the remaining 40% is derived from mitochondrial oxidative phosphorylation.
Scientific Papers found: Click to Expand⟱
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE/β-secretase↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
3447- ALA,    Redox Active α-Lipoic Acid Differentially Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer and Its Control Cells
- in-vitro, AD, SH-SY5Y
*ATP↑, *MMP↑, *ROS↓, *GlucoseCon↑, *GSH↑, *neuroP↑, *cognitive↑, *Ach↑, *Inflam↓, *Aβ↓, OXPHOS↓,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
5326- ALC,    L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro
- vitro+vivo, Liver, HepG2
TumCG↓, P21↑, ac‑H3↑, HDAC↓, *ATP↑, selectivity↑, ac‑H4↑,
3159- Ash,    Neuroprotective effects of Withania somnifera in the SH-SY5Y Parkinson cell model
- in-vitro, Park, SH-SY5Y
*neuroP↑, *Inflam↓, *ROS↓, *cognitive↑, *memory↑, *GPx↑, *Prx↓, *ATP↑, *Vim↓, *mtDam↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
2348- CAP,    Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
- Analysis, Nor, NA
Warburg↓, *PKM2↓, *COX2/PTGS2↓, *Inflam↓, *Sepsis↓, *AMPK↑, *PKA↑, *mitResp↑, *FAO↑, *FASN↓, *PGM1?, *ATP↑, *ROS↓,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, Asthma, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2/PTGS2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *Synergy↑, *BChE↓, *CRP↓, *antiAll↑,
6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,
6632- Cic,    Chicoric Acid Ameliorates Lipopolysaccharide-Induced Oxidative Stress via Promoting the Keap1/Nrf2 Transcriptional Signaling Pathway in BV-2 Microglial Cells and Mouse Brain
- vitro+vivo, Nor, NA
*antiOx↑, *Obesity↓, *NRF2↑, *HO-1↑, *NQO1↑, *ROS↓, *GSH↑, *Catalase↑, *SOD↑, *ATP↑, *COX2/PTGS2↓, *iNOS↓, *neuroP↑,
8995- Citicoline,    Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport
- in-vivo, Stroke, NA
*Dose↝, *Stroke↓, *other↝, *ATP↑, *neuroP↑,
8998- Citicoline,  Rad,    The impact of citicoline on brain mitochondrial dysfunction induced in rats after head irradiation
- in-vivo, Nor, NA
*Dose↝, *ROS↓, *compI↑, *compIII↑, *ATP↑, *Ca+2↓, *Iron↓, *Casp3↓, *glucose↝, *ACE/ACE1↑, *AChE↓,
6298- Cro,    Crocetin Prevents RPE Cells from Oxidative Stress through Protection of Cellular Metabolic Function and Activation of ERK1/2
- in-vitro, AMD, RPE-1
*ATP↑, *antiOx↑, *ROS↓,
6293- Cro,    Crocetin: an agent derived from saffron for prevention and therapy for cancer
- Review, Var, NA
*toxicity↓, *lipid-P↓, *neuroP↑, *BloodF↑, *BP↓, *RenoP↑, *ATP↑, AntiCan↑, TumCP↓, Apoptosis↑, lipid-P↓, ROS↓, GSTs↑, Catalase↑, SOD↑,
6408- CUR,    Protective Effects of a Natural Product, Curcumin, against Amyloid β Induced Mitochondrial and Synaptic Toxicities in Alzheimer'S Disease
- in-vitro, AD, SH-SY5Y
*mtDam↓, *eff↓, *eff↑, *FIS1↓, *lipid-P↓, *ATP↑,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
7235- EGb 761,    Stabilization of Mitochondrial Membrane Potential and Improvement of Neuronal Energy Metabolism by Ginkgo Biloba Extract EGb 761
- in-vitro, AD, NA
*MMP↑, *ATP↑,
7240- EGb 761,    EGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation
- in-vitro, Nor, NA
*ATP↑, *ROS↓, *hepatoP↑,
6829- EMD,    Molecular Mechanisms of Action of Emodin: As an Anti-Cardiovascular Disease Drug
- Review, Nor, NA
*diuretic↑, *Bacteria↓, *AntiViral↑, *Inflam↓, AntiCan↑, *cardioP↑, *NF-kB↓, *TNF-α↓, *IL1β↓, *NO↑, *eNOS↑, *PPARγ↑, *Casp9↓, *Casp3↓, *GSDMD↓, *Bcl-2↑, *STAT3↑, *ATP↑, *SOD↑, *GSH↑, *HDAC2↓, *SIRT3↑, ROS↑, PCNA↓, P53↑, cMyc↓,
4251- FA,    Antidepressant-Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity
- in-vivo, AD, NA
*BDNF↑, *ATP↑, *Mood↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
7195- GBE,    Mitochondrial effects of Ginkgo biloba extract
- Review, AD, NA
*ROS↓, *mitResp↑, *AntiAge↑, *ATP↑, *neuroP↑, *ETC↑, *compI↑,
7212- GBE,    The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *mitResp↑, *Casp9↓, *Casp3↓, *Apoptosis↓, *ATP↑, *neuroP↑, *IL1β↓, *IL6↓, *TNF-α↓, *PGE2↓, *memory↑, *cognitive↑, *BloodF↑, *lipid-P↓, *Aβ↓, *MAOA↓, *DA↑, *Dose↝, *toxicity↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7483- H2,  Cisplatin,    Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism
- in-vivo, Nor, HK-2
RenoP↑, BHB↑, HMGCS2↑, chemoP↑, *IL2↓, *IL6↓, *MCP1/CCL2↓, *TNF-α↓, *KeyT↝, *Inflam↓, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *PGC-1α↑, *BUN↓, *creat↓,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *BP∅, *BBB↑,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, Asthma, NA
*selectivity↑, *lactateProd↓, *ATP↑, *HK2↓, *PFK↓, *Hif1a↓, *PGC-1α↑, *Glycolysis↓, *OXPHOS↑, *Dose↝, *antiAll↑,
2887- HNK,    Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming
- in-vitro, AD, BV2
*Glycolysis↑, *ATP↑, *ROS↓, *MMP↑, *OXPHOS↑, *PPARα↑, *PGC-1α↑,
7636- Ins,    Myo-Inositol: Pharmacokinetics, Biological Functions, and Therapeutic Potential in Liver Protection: Insights from Preclinical Models
- Review, Nor, NA
*glucose↝, *lipid-P↓, *ROS↓, *BioAv↑, *hepatoP↑, *Inflam↓, *MMP↑, *ATP↑, *GutMicro↑, *Dose↝, *Half-Life↝, *BioAv↑, *Synergy↑, *hepatoP↑, *SOD↑, *Catalase↑, *Casp3↓, *ALAT↓, *AST↓, *AMPK↑, *SREBP1/SREBF1↑, NA↑,
7755- ISL,    Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *p‑T-cadherin↓, *ROS↓, *ATP↑, *p‑DRP1/DNM1L↝, *MFN1↝, *MFN2↝, *neuroP↑, *cognitive↑, *mTOR↓, *ERK↓, *GSK‐3β↑,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE/β-secretase↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *Synergy↑,
8417- Lyco,    Lycopene alleviates age-related cognitive deficit via activating liver-brain fibroblast growth factor-21 signalling
- in-vivo, AD, NA
*cognitive↑, *FGF21↑, *ATP↑,
8734- M-Blu,    From Mitochondrial Function to Neuroprotection – An Emerging Role for Methylene Blue
- Review, AD, NA
*ETC↑, *compIV↑, *ROS↓, *NeuroI↓, *neuroP↑, *Stroke↓, *cognitive↑, *BBB↑, *BloodF↑, *NOS2↓, *lipid-P↓, *Inflam↓, *Synergy↑, *OCR↑, *compIV↑, *ATP↑, *Casp↓, *MMP↑, *tau↓,
8733- M-Blu,    Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
- Review, AD, NA - Review, Stroke, NA
*ETC↑, *ROS↓, *Inflam↓, *memfluid↑, *BloodF↑, *BBB↑, *OCR↑, *ATP↑, *BioAv↑, *Aβ↓, *compIV↑, *Stroke↓, *compI↑, *compII↑, *compIII↑, *GlucoseCon↑, *neuroG↑,
2643- MCT,    Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism
- Review, Nor, NA
*Akt↑, *AMPK↓, *TGF-β↓, eff↑, *BioEnh↑, *ATP↑, *PGC-1α↑, *p‑mTOR↑, *SMAD3↓,
2247- MF,    Effects of Pulsed Electromagnetic Field Treatment on Skeletal Muscle Tissue Recovery in a Rat Model of Collagenase-Induced Tendinopathy: Results from a Proteome Analysis
- in-vivo, Nor, NA
*Glycolysis↓, *LDHB↑, *NAD↑, *ATP↑, *antiOx↑, *ROS↑, *YAP/TEAD↑, *PGC-1α↑, *TCA↑, *FAO↑, *OXPHOS↑,
3477- MF,    Electromagnetic fields regulate calcium-mediated cell fate of stem cells: osteogenesis, chondrogenesis and apoptosis
- Review, Var, NA
*Ca+2↑, *VEGF↑, *angioG↑, Ca+2↑, ROS↑, Necroptosis↑, TumCCA↑, Apoptosis↑, *ATP↑, *FAK↑, *Wnt↑, *β-catenin/ZEB1↑, *ROS↑, p38↑, MAPK↑, β-catenin/ZEB1↓, CSCs↓, TumCP↓, ROS↑, RadioS↑, Ca+2↑, eff↓, NO↑,
4355- MF,    Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism
- in-vitro, Nor, C2C12
*mt-OCR↑, *mt-ROS↑, *ECAR↑, *Dose↝, *Ca+2↑, *ATP↑, *other↑, *eff↓, *eff↝,
1778- MLT,    Melatonin: a well-documented antioxidant with conditional pro-oxidant actions
- Review, Var, NA - Review, AD, NA
*ROS↓, *antiOx↓, ROS↑, selectivity↑, Dose↑, *mitResp↑, *ATP↑, *ROS↓, eff↑, ROS↑, Dose↑, *toxicity∅, ROS↑, eff↓, ROS↝, Dose↑, other↑,
1780- MLT,    Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing
- Review, Var, NA
*antiOx↑, *toxicity↓, ChemoSen↑, *eff↑, *mitResp↑, *ATP↑, *ROS↓, *CardioT↓, *GSH↑, *NOS2↓, *lipid-P↓, eff↑, *HO-1↑, *NRF2↑, *NF-kB↑, TumCP↓, eff↑, neuroP↑,
6419- MLT,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
8915- MO,    Therapeutic Potential of Moringa oleifera in Alzheimer’s Disease: A Review of Neuroprotective Mechanisms
- Review, AD, NA
*Ingr↝, *antiOx↑, *Inflam↓, *NRF2↑, *ARE↑, *AChE↓, *Aβ42↓, *cognitive↑, *BACE/β-secretase↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *Learn↑, *memory↑, *ATP↑, *SOD↑, *Catalase↑, *p‑tau↓,
3350- QC,    Quercetin and the mitochondria: A mechanistic view
- Review, Var, NA
*antiOx↑, *Inflam↓, *NRF2↑, ROS⇅, *NRF2↑, *HO-1↑, *PPARα↑, *PGC-1α↑, *SIRT1↑, *ATP↑, ATP↓, ERK↓, cl‑PARP↑, Casp9↑, Casp8↑, BAX↑, MMP↓, Cyt‑c↑, Casp3↑, HSP27↓, HSP72↓, RAS↓, Raf↓,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
6420- RES,    Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity
- in-vivo, Park, NA
*DRP1/DNM1L↑, *FIS1↑, *OPA1↑, *MFN2↑, *motorD↑, *PGC-1α↑, *ROS↓, *ATP↑,
6423- RES,    Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity
- vitro+vivo, Park, NA
*neuroP↑, *FIS1↓, *OPA1↓, *MFN2↓, *PGC-1α↑, *ROS↓, *ATP↑, *motorD↑,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3729- RF,    Review of the Evidence that Transcranial Electromagnetic Treatment will be a Safe and Effective Therapeutic Against Alzheimer's Disease
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *ROS↓, *ATP↑,
3733- RF,    Long-term electromagnetic field treatment enhances brain mitochondrial function of both Alzheimer's transgenic mice and normal mice: a mechanism for electromagnetic field-induced cognitive benefit?
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *mt-ROS↓, *ATP↑,

Showing Research Papers: 1 to 50 of 62
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 62

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   ROS↓, 1,   ROS↑, 7,   ROS⇅, 1,   ROS↝, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OXPHOS↓, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 1,   BHB↑, 1,   Glycolysis↓, 1,   GSK‐3β↑, 1,   HMGCS2↑, 1,   SCD1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 7,   Bak↓, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   BID↑, 1,   Casp3↑, 3,   Casp8↑, 2,   Casp9↑, 3,   Cyt‑c↑, 3,   Fas↑, 1,   IAP2/BIRC3↓, 1,   Mcl-1↓, 1,   Necroptosis↑, 1,   p38↑, 1,   TumCD↑, 1,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   EGFR↓, 1,   EGFR↑, 1,   ERK↓, 3,   HER2/EBBR2↓, 1,   MAPK↑, 1,   PI3K↓, 2,   p‑PI3K↓, 1,   Raf↓, 1,   RAS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   EZH2↓, 1,   ac‑H3↑, 1,   ac‑H4↑, 1,   HDAC↓, 1,   miR-124-3p↓, 1,   miR-34a↑, 1,   other↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,   HSP72↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   P53↑, 4,   PARP↑, 2,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↓, 1,   CDK6↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 1,   mitA↑, 1,   P21↑, 2,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs?, 1,   CSCs↓, 1,   FGF↓, 1,   Ki-67↓, 1,   TumCG↓, 1,   TumCP↓, 6,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   Ca+2↑, 2,   LAMs↓, 1,   MALAT1↓, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 3,   NO↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 2,   HMGB1↓, 1,   NF-kB↓, 3,   NF-kB↑, 1,   NK cell↑, 1,   PD-1↓, 1,   PGE2↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER-α36↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 4,   Dose↑, 3,   Dose↝, 2,   eff↓, 2,   eff↑, 7,   RadioS↑, 2,   selectivity↑, 3,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

CEA↓, 1,   EGFR↓, 1,   EGFR↑, 1,   EZH2↓, 1,   HER2/EBBR2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   chemoP↑, 2,   neuroP↑, 1,   NP/CIPN↓, 2,   PFS↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   TumVol↓, 1,  
Total Targets: 122

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 23,   ARE↑, 1,   Catalase↑, 13,   GPx↑, 10,   GPx4↑, 1,   GSH↑, 14,   GSR↓, 1,   GSR↑, 1,   GSTs↑, 1,   H2O2↓, 3,   HO-1↓, 1,   HO-1↑, 9,   Iron↓, 1,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 15,   mt-lipid-P↓, 1,   MDA↓, 9,   MPO↓, 3,   NQO1↑, 3,   Nrf1↑, 1,   NRF2↑, 16,   Prx↓, 1,   Prx↑, 1,   ROS↓, 45,   ROS↑, 2,   mt-ROS?, 1,   mt-ROS↓, 1,   mt-ROS↑, 1,   SOD↑, 14,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 1,   Trx↑, 1,   uricA↓, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 3,   compII↑, 2,   compIII↑, 3,   compIV↑, 3,   DRP1/DNM1L↓, 2,   DRP1/DNM1L↑, 1,   p‑DRP1/DNM1L↝, 1,   ETC↑, 4,   FIS1↓, 3,   FIS1↑, 1,   Insulin↑, 1,   MFN1↑, 1,   MFN1↝, 1,   MFN2↓, 1,   MFN2↑, 4,   MFN2↝, 1,   mitResp↑, 6,   mtDam↓, 3,   OCR↑, 3,   mt-OCR↑, 1,   OPA1↓, 1,   OPA1↑, 2,   OXPHOS↑, 4,   PGC-1α↑, 10,   PGC-1α↝, 1,   PINK1↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   mt-ACC⇅, 1,   Acetyl-CoA↑, 1,   ALAT↓, 4,   AMPK↓, 1,   AMPK↑, 7,   ATP↑, 62,   mt-ATP↑, 1,   ECAR↑, 1,   FAO↑, 3,   FASN↓, 1,   G6PD↑, 1,   glucose↓, 2,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 5,   Glycolysis↓, 2,   Glycolysis↑, 1,   Glycolysis↝, 2,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   HK2↓, 2,   KeyT↝, 1,   lactateProd↓, 2,   LDHA↓, 1,   LDHB↑, 1,   LDL↓, 2,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 3,   NADPH↑, 2,   PDKs↑, 1,   PFK↓, 2,   PFK2↓, 1,   PGM1?, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PPP↓, 1,   SCFAs↑, 1,   SIRT1↑, 3,   SREBP1/SREBF1↑, 1,   TCA↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 5,   BAX↓, 1,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 4,   Casp↓, 1,   Casp12↓, 1,   Casp3↓, 9,   Casp3↑, 1,   Casp9↓, 3,   Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c∅, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   GSDMD↓, 1,   iNOS↓, 6,   p38↓, 1,   YAP/TEAD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 4,   CREB↑, 1,   ERK↓, 1,   Hippo↑, 1,   p‑JNK↓, 1,   MAPK↓, 2,   mTOR↓, 3,   mTOR↑, 1,   p‑mTOR↑, 1,   PI3K↓, 2,   PI3K↑, 3,   PKA↑, 1,   PP2A↑, 1,   STAT↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   ATF4↓, 1,   FOXO↑, 1,   FOXO3↑, 2,   HDAC2↓, 1,   other↑, 5,   other↝, 4,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↝, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   MitoP↑, 3,   p62↓, 1,   p62↑, 2,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HH↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 2,   NOTCH1↑, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↓, 3,   Ca+2↑, 3,   Cartilage↑, 1,   FAK↑, 1,   MMP13↓, 1,   MMP9↓, 1,   SMAD3↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   Vim↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   eNOS↑, 1,   Hif1a↓, 1,   NO↓, 2,   NO↑, 1,   VCAM-1↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 8,   BBB↝, 1,   GastroP↑, 2,   GLUT4↑, 1,   H+/K+-ATPase↓, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↑, 14,   TRPV3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2,   CD8+↑, 1,   COX2/PTGS2↓, 6,   COX2/PTGS2↑, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 12,   IL2↓, 2,   IL33↓, 1,   IL4↓, 2,   IL6↓, 10,   IL6↑, 1,   IL8↓, 1,   Imm↑, 2,   INF-γ↓, 1,   Inflam↓, 28,   LPS↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   NeuroI↓, 1,   NF-kB↓, 9,   NF-kB↑, 1,   p‑NF-kB↓, 1,   NK cell↑, 1,   NLRP3↓, 3,   p65↓, 1,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 15,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 3,   AChE↓, 8,   BChE↓, 2,   BDNF↑, 5,   ChAT↑, 2,   DA↑, 1,   MAOA↓, 2,   MAOB↓, 1,   NGF↑, 2,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 5,   Aβ↓, 21,   Aβ42↓, 1,   BACE/β-secretase↓, 8,   tau↓, 2,   p‑tau↓, 8,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE/ACE1↑, 1,   ACE2↓, 1,   ER(estro)↓, 1,   FGF21↑, 1,   PPARα↑, 2,   PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 10,   BioAv↝, 6,   BioEnh↑, 1,   Dose↝, 8,   eff↓, 2,   eff↑, 7,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 2,   selectivity↑, 1,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   AST↓, 4,   BloodF↑, 5,   BP↓, 2,   BP↝, 1,   BP∅, 1,   BUN↓, 1,   creat↓, 3,   CRP↓, 3,   Hcy/homoC↓, 1,   IL6↓, 10,   IL6↑, 1,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 1,   NOS2↓, 2,   TC↓, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 4,   AntiCan↑, 1,   AntiDiabetic↑, 3,   antiPs↑, 2,   cardioP↑, 9,   CardioT↓, 1,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 22,   diuretic↑, 1,   hepatoP↑, 8,   Learn↑, 1,   memory↑, 14,   Mood↑, 1,   motorD↑, 6,   neuroP↑, 27,   Obesity↓, 6,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 4,   Risk↓, 2,   Strength↑, 1,   Stroke↓, 6,   toxicity↓, 8,   toxicity↝, 2,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 3,   Diar↓, 1,   GutMicro↑, 6,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 1,  
Total Targets: 334

Scientific Paper Hit Count for: ATP, Adenosine triphosphate
4 Hydrogen Gas
4 Urolithin
3 Magnetic Fields
3 Melatonin
3 Resveratrol
2 Alpha-Lipoic-Acid
2 Citicoline, CDP-Choline
2 Crocetin
2 Curcumin
2 Ginkgo biloba-EGb 761
2 Ginkgo biloba
2 Luteolin
2 Methylene blue
2 Quercetin
2 EGCG (Epigallocatechin Gallate)
2 Vitamin B5,Pantothenic Acid
1 Anthocyanins
1 Acetyl-l-carnitine
1 Ashwagandha(Withaferin A)
1 α-Bisabolol / Chamomile oil
1 Capsaicin
1 Carvacrol
1 Centella asiatica / Gotu kola → asiaticoside
1 Cichoric acid / Chicoric acid
1 Radiotherapy/Radiation
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Emodin
1 Ferulic acid
1 Formononetin
1 Cisplatin
1 Honokiol
1 Inositol
1 Isoliquiritigenin
1 Lycopene
1 MCT oil
1 Moringa oleifera
1 Radio Frequency
1 EMF
1 Rosmarinic acid
1 Docosahexaenoic Acid
1 Vitamin B1/Thiamine
1 Vitamin B12
1 Folic Acid, Vit B9
1 Vitamin B2,Riboflavin
1 Vitamin K2
1 probiotics
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:21  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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