NK cell Cancer Research Results

NK cell, NK cell activity: Click to Expand ⟱
Source: HalifaxProj(promote)
Type:
Natural Killer (NK) cells are a type of lymphocyte in the immune system that play a crucial role in the body's defense against tumors and virally infected cells.
NK cells can directly kill cancer cells through the release of cytotoxic granules containing perforin and granzymes. Perforin forms pores in the target cell membrane, allowing granzymes to enter and induce apoptosis (programmed cell death).
NK cells produce various cytokines, such as interferon-gamma (IFN-γ), which can enhance the immune response and promote the activation of other immune cells, including macrophages and T cells.
-Monoclonal Antibodies: Using antibodies that engage NK cells to target and kill cancer cells.
-Cytokine Therapy: Administering cytokines like IL-2 or IL-15 to boost NK cell activity.
Scientific Papers found: Click to Expand⟱
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
7436- Chy,  Amla,    A Review on the Role of Amla and Chyawanprash in Immunity Enhancement and Disease Prevention
- Review, Nor, NA
*VitC↑, *memory↑, *Imm↑, *NK cell↑, *antiOx↑, *neuroP↑, *cognitive↑,
9097- CV,    Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of natural killer cell activity and early inflammatory response (randomized, double-blinded, placebo-controlled trial)
- Trial, Nor, NA
*Dose↝, *IFN-γ↑, *NK cell↑,
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
6616- Ech,    Natural killer cells from aging mice treated with extracts from Echinacea purpurea are quantitatively and functionally rejuvenated
- in-vivo, Nor, NA
*NK cell↑, *Imm↑,
6609- Ech,  Cic,    Echinacea purpurea Extract Enhances Natural Killer Cell Activity In Vivo by Upregulating MHC II and Th1-type CD4+ T Cell Responses
- in-vivo, Nor, NA
*Dose↝, *CD4+↑, *Th1 response↑, *NK cell↑, *Imm↑,
6610- Ech,  Cic,    A standardized extract of Echinacea purpurea containing higher chicoric acid content enhances immune function in murine macrophages and cyclophosphamide-induced immunosuppression mice
- in-vivo, Nor, NA
*NK cell↑, *Imm↑, Dose↝,
6634- Ech,    Echinacea purpurea: Pharmacology, phytochemistry and analysis methods
- Review, Var, NA
AntiArt↑, *Imm↑, *Neut↑, *NK cell↑, *COX1↓, *COX2/PTGS2↓, *Inflam↓, TumCG↑, *toxicity↓,
6620- Ech,    Echinacea purpurea diminishes neovascular reaction induced in mice skin by human cancer cells and stimulates non-specific cellular immunity in humans
- in-vivo, Var, NA
angioG↓, *NK cell↑, Imm↑, Inflam↓, tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, MMPs↓, other↑,
7015- Fuc,    Effects of Ingesting Fucoidan Derived from Cladosiphon okamuranus Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study
- Trial, Nor, NA
*NK cell↑, *toxicity↓,
7126- Ge-132,    Immune activation of Bio-Germanium in a randomized, double-blind, placebo-controlled clinical trial with 130 human subjects: Therapeutic opportunities from new insights
- Trial, Nor, NA
AntiTum↑, AntiCan↑, *AntiAge↑, *AntiViral↑, *Inflam↓, *NK cell↑, *Imm↑, *TNF-α↑,
9252- ISO, IH,    Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, mtDam↑, MMPs↓, VEGF↓, EMT↓, *antiOx↓, *Inflam↓, *ROS↓, MDR1↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, Ingr↝, TumCCA↑, CycB/CCNB1↓, CDK1↓, P21↑, ROS↑, AMPK↑, *Ferroptosis↓, *NRF2↑, *HO-1↑, *IronCh↑, *lipid-P↓, *GSH↑, *ACSL4↓, *COX2/PTGS2↓, VEGF↓, angioG↓, E-cadherin↑, N-cadherin↓, uPA↓, *NK cell↑, radioP↑, Imm↑, Neut↑, Eos↑,
9309- MushMait,    Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial
- Trial, Nor, NA
*Dose↝, *cognitive↑, *NK cell↑, *Imm↑, *other↝,
5087- SSE,    Sodium Selenite Alleviates Breast Cancer-Related Lymphedema Independent of Antioxidant Defense System
- Trial, BC, NA
eff↑, Inflam↓, Imm↑, ROS↑, *NK cell↑,

Showing Research Papers: 1 to 14 of 14

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 2,   Casp7↑, 2,   Casp8↑, 1,   Casp9↑, 1,   Fas↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   MAPK↓, 1,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   Ki-67↓, 1,   P21↑, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,   TumCG↓, 1,   TumCG↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   EMT↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 2,   N-cadherin↓, 1,   uPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Eos↑, 1,   Imm↑, 3,   Inflam↓, 2,   Neut↑, 1,   NF-kB↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER-α36↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,   MDR1↓, 1,   Synergy↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiArt↑, 1,   AntiCan↑, 1,   AntiTum↑, 2,   radioP↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 53

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↑, 1,   GPx↑, 2,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 3,   MDA↓, 1,   NRF2↑, 2,   ROS↓, 3,   SOD↑, 2,   TAC↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   ATP↑, 1,   LDL↓, 1,   SCFAs↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 3,   IFN-γ↑, 2,   IL10↑, 1,   IL6↓, 1,   Imm↑, 7,   Inflam↓, 4,   Neut↑, 1,   NF-kB↓, 2,   NK cell↑, 14,   Th1 response↑, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 4,   P450↓, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↝, 1,   CRP↓, 1,   IL6↓, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 2,   toxicity↓, 2,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 61

Scientific Paper Hit Count for: NK cell, NK cell activity
5 Echinacea
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Chlorella (Chlorella vulgaris)
2 Cichoric acid / Chicoric acid
1 Chyawanprash
1 Spirulina(Arthrospira/Limnospira)
1 Fucoidan
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Isorhamnetin
1 Mushroom Maitake
1 Selenite (Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:219  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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