NRF2 Cancer Research Results

NRF2, nuclear factor erythroid 2-related factor 2: Click to Expand ⟱
Source: TCGA
Type: Antiapoptotic
Nrf2 is responsible for regulating an extensive panel of antioxidant enzymes involved in the detoxification and elimination of oxidative stress. Thought of as "Master Regulator" of antioxidant response.
-One way to estimate Nrf2 induction is through the expression of NQO1.
NQO1, the most potent inducer:
SFN 0.2 μM,
quercetin (2.5 μM),
curcumin (2.7 μM),
Silymarin (3.6 μM),
tamoxifen (5.9 μM),
genistein (6.2 μM ),
beta-carotene (7.2μM),
lutein (17 μM),
resveratrol (21 μM),
indol-3-carbinol (50 μM),
chlorophyll (250 μM),
alpha-cryptoxanthin (1.8 mM),
and zeaxanthin (2.2 mM)

1. Raising Nrf2 enhances the cell's antioxidant defenses and ↓ROS. This strategy is used to decrease chemo-radio side effects.
2. Downregulating Nrf2 lowers antioxidant defenses and ↑ROS. In cancer cells this leads to DNA damage, and cell death.
3. However there are some cases where increasing Nrf2 paradoxically causes an increase in ROS (cancer cells). Such as cases of Mitochondial overload, signal crosstalk, reductive stress

-In some cases, Nrf2 is overexpressed in cancer cells, which can lead to the activation of genes involved in cell proliferation, angiogenesis, and metastasis. This can contribute to the development of resistance to chemotherapy and targeted therapies.
-Increased Nrf2 expression: Lung, Breast, Colorectal, Prostrate.
Decreased Nrf2 expression: Skine, Liver, Pancreatic.
-Nrf2 is a cytoprotective transcription factor which demonstrated both a negative effect as well as a positive effect on cancer
- "promotes Nrf2 translocation from the cytoplasm to the nucleus," means facilitates the movement of Nrf2 into the nucleus, thereby enhancing the cell's antioxidant and cytoprotective responses. -Major regulator of Nrf2 activity in cells is the cytosolic inhibitor Keap1.

Nrf2 Inhibitors and Activators
Nrf2 Inhibitors: Brusatol, Luteolin, Trigonelline, VitC, Retinoic acid, Chrysin
Nrf2 Activators: SFN, OPZ EGCG, Resveratrol, DATS, CUR, CDDO, Api
- potent Nrf2 inducers from plants include sulforaphane, curcumin, EGCG, resveratrol, caffeic acid phenethyl ester, wasabi, cafestol and kahweol (coffee), cinnamon, ginger, garlic, lycopene, rosemany

Nrf2 plays dual roles in that it can protect normal tissues against oxidative damage and can act as an oncogenic protein in tumor tissue.
– In healthy tissues, NRF2 activation helps protect cells from oxidative damage and maintains cellular homeostasis.
– In many cancers, constitutive activation of NRF2 (often through mutations in NRF2 itself or loss-of-function mutations in KEAP1) leads to an enhanced antioxidant capacity.
– This upregulation can promote tumor cell survival by enabling cancer cells to thrive under oxidative stress, resist chemotherapeutic agents, and sustain metabolic reprogramming.
– Elevated NRF2 levels have been implicated in promoting tumor growth, metastasis, and resistance to therapy in various malignancies.
– High or sustained NRF2 activity is frequently associated with aggressive tumor phenotypes, poorer prognosis, and decreased overall survival in several cancer types.
– While its activation is essential for protecting normal cells from oxidative stress, aberrant or sustained NRF2 activation in tumor cells can lead to enhanced survival, therapeutic resistance, and tumor progression.

NRF2 inhibitors: (to decrease antioxidant defenses and increase cell death from ROS).
-Brusatol: most cited natural inhibitors of Nrf2.
-Luteolin: luteolin can reduce Nrf2 activity in specific cancer models and may enhance cell sensitivity to chemotherapy. However, luteolin is also known as an antioxidant, and its influence on Nrf2 can sometimes be context dependent.
-Apigenin: certain studies to down‑regulate Nrf2 in cancer cells: Dose and context dependent .
-Oridonin:
-Wogonin: although its effects might be cell‑ and dose‑specific.
- Withaferin A

Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
6474- 1,8-Cin,    Molecular Docking Identifies 1,8-Cineole (Eucalyptol) as A Novel PPARγ Agonist That Alleviates Colon Inflammation
- in-vitro, Nor, HT29 - in-vivo, Nor, NA - in-vivo, IBD, NA
*Inflam↓, *NRF2↑, *antiOx↑, *PPARγ↑, eff↑,
4434- AgNPs,  SSE,    Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway
- vitro+vivo, Nor, NA
*ROS↓, *Inflam↓, *NLRP3↓, *NF-kB↓, *NRF2↑, *HO-1↑, *toxicity↓,
9228- AITC,  BITC,  PEITC,    Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts
- in-vitro, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑,
9236- AITC,    Allyl Isothiocyanate Protects Acetaminophen-Induced Liver Injury via NRF2 Activation by Decreasing Spontaneous Degradation in Hepatocyte
- in-vivo, LiverDam, NA
*NRF2↑, *hepatoP↑, *HO-1↑,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
236- AL,    Allicin: Chemistry and Biological Properties
- Analysis, Nor, NA
*GSH↓, *Bacteria↓, *LDL↓, *ROS↑, *NRF2↑, *cognitive↑, *memory↑, *BP↓, *RNS↓,
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
1235- ALA,  Cisplatin,    α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
- in-vitro, Nor, HEI-OC1 - ex-vivo, NA, NA
ROS↑, HO-1↓, *toxicity↓, chemoP↑, *ROS↓, *HO-1↑, *SOD1↑, *NRF2↑,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3449- ALA,    Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells
- in-vitro, AD, SK-N-BE
*antiOx↑, *NRF2↑, *NF-kB↓, *IL1β↓, *IL6↓, neuroP↑,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
3541- ALA,    Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology
- Review, Var, NA
*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
1562- Api,    Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway
- in-vitro, Vit, NA
*SOD↑, *Catalase↑, *GPx↑, *MDA↓, *NRF2↑, *toxicity∅,
1561- Api,    Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications
- in-vivo, Nor, JB6
*NRF2↑, *DNMT1↓, *DNMT3A↓, *HDAC↓, *AntiCan↑,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
2318- Api,    Apigenin as a multifaceted antifibrotic agent: Therapeutic potential across organ systems
- Review, Nor, NA
*ROS↓, *PKM2↓, *Hif1a↓, *TGF-β↓, *AMPK↑, *Inflam↓, *PI3K↓, *Akt↑, *NRF2↑, *NF-kB↓,
4278- ART/DHA,    Artemisinin Ameliorates the Neurotoxic Effect of 3-Nitropropionic Acid: A Possible Involvement of the ERK/BDNF/Nrf2/HO-1 Signaling Pathway
- in-vivo, Var, NA
*IL6↓, *Casp3↓, *Casp9↓, *BDNF↑, *ERK↑, *NRF2↑, *HO-1↑, *neuroP↑, *antiOx↑, *Inflam↓,
4991- ART/DHA,  doxoR,    Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy
- in-vivo, Nor, H9c2
*cardioP↑, *ROS↓, *Ferroptosis↓, *NRF2↑, Keap1↓,
3174- Ash,    Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
NF-kB↓, angioG↓, Inflam↓, TumCP↓, TumCMig↓, TumCI↓, Sp1/3/4↓, VEGF↓, angioG↓, uPA↓, PDGF↓, MCP1/CCL2↓, ICAM-1↓, *NRF2↑, *hepatoP↑,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP/DDIT3↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3161- Ash,    Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
- in-vivo, Stroke, NA
*neuroP↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *NRF2↑, *HO-1↑,
3164- Ash,    Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
- in-vitro, Nor, NA
*hepatoP↑, *IKKα↓, *NLRP3↓, *NRF2↑, *AMPK↑, *Inflam↓, *Apoptosis↓, *cl‑Casp3↓, *cl‑PARP1↓, *NLRP3↓, *ROS↓, *ALAT↓, *AST↓, *GSH↑,
3163- Ash,  Rad,    Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis
- in-vitro, Var, NA
*radioP↑, selectivity↑, *Casp3↓, *DNAdam↓, *ROS↓, *GSH↓, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *Prx↑, *ERK↑,
5425- ASTX,    Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE/β-secretase↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,
4815- ASTX,    The Promising Effects of Astaxanthin on Lung Diseases
- Review, Var, NA
Dose↑, *BioAv↝, *BioAv↝, *antiOx↑, *NRF2↑, *ERK↓, *antiAll↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
5501- Ba,    Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review
- Review, GC, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, BAX↑, TumAuto↑, ROS↑, NRF2↝, PI3K↓, Akt↓, NF-kB↓, TGF-β↓, SMAD4↓, GPx4↓, MMP↓, *HO-1↑, *GSTs↑, *antiOx↑, *AntiTum↑, *NRF2↑, ChemoSen↑, Akt↓, mTOR↓, FAK↓, Ki-67↓,
4305- Ba,    Study on the Molecular Mechanism of Baicalin Phosphorylation of Tau Protein Content in a Cell Model of Intervention Cognitive Impairment
- in-vitro, AD, SH-SY5Y
*cognitive↑, *p‑Akt↑, *p‑GSK‐3β↑, *p‑tau↓, *neuroP↑, *NF-kB↓, *AMPK↑, *NRF2↑,
1530- Ba,    Baicalein Decreases Hydrogen Peroxide‐Induced Damage to NG108‐15 Cells via Upregulation of Nrf2
- in-vitro, Nor, NG108-15
*12LOX↓, *ROS↓, *NRF2↑, *eff↑,
1527- Ba,    Baicalein Alleviates Arsenic-induced Oxidative Stress through Activation of the Keap1/Nrf2 Signalling Pathway in Normal Human Liver Cells
- in-vitro, Nor, MIHA
*p‑NRF2↑, *ROS↓, *MDA↓, *antiOx↑,
2623- Ba,    Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of baicalein against oxidative stress-induced DNA damage and apoptosis in HEI193 Schwann cells
- in-vitro, Nor, HEI193
*DNAdam↓, *ROS↓, *Bax:Bcl2↓, *p‑NRF2↑, *HO-1↑, *neuroP↑, *MMP↑,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
5552- BBM,    Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosine monophosphate‐activated protein kinase/nuclear factor erythroid 2‐related factor pathway and changes in the mitochondrial state
- in-vivo, Stroke, NA
*eff↑, *ROS↓, *mtDam↓, *AMPK↑, *NRF2↑, *NADPH↑, *HO-1↑, *cardioP↑,
1380- BBR,  doxoR,    treatment with ROS scavenger N-acetylcysteine (NAC) and JNK inhibitor SP600125 could partially attenuate apoptosis and DNA damage triggered by DCZ0358.
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑,
3678- BBR,    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
- Review, AD, NA
*APP↓, *PPARγ↑, *NF-kB↓, *Aβ↓, *cognitive↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *BioAv↑, *BioAv↝, *BBB↑, *motorD↑, *NRF2↑, *HO-1↑, *ROS↓, *p‑Akt↑, *p‑ERK↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6517- BCP,    β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways
- in-vivo, Nor, NA
*cardioP↑, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *TLR4↓, *NF-kB↓, *Inflam↓, *Apoptosis↓,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1/ATG6↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2/PTGS2↓, *p62↓, *NP/CIPN↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
6507- BCP,    Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation
- Review, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *TLR4↓, *NF-kB↓, *NLRP3↓, *MAPK↓, *NRF2↑, *HO-1↑, *PI3K↑, *Akt↑, *cAMP↑, *PKA↑, *CREB↑,
2725- BetA,    Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice
- in-vivo, Nor, NA
*RenoP↑, *SOD?, *Catalase↑, *GSH↑, *ROS↓, *MDA↓, *IL1β↓, *TNF-α↓, *IL10↓, *IL6↑, *NRF2↑,

Showing Research Papers: 1 to 50 of 432
Page 1 of 9 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 432

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 4,   Catalase↑, 2,   Fenton↑, 3,   GPx↑, 1,   GPx4↓, 4,   GSH↓, 8,   GSH↑, 3,   GSH/GSSG↓, 1,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 2,   H2O2↓, 1,   H2O2↑, 3,   HO-1↓, 3,   HO-1↑, 9,   Iron↑, 3,   Keap1↓, 1,   Keap1↑, 1,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↑, 3,   MDA↓, 1,   MDA↑, 3,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 1,   NQO1↑, 2,   NRF2↓, 10,   NRF2↑, 4,   NRF2⇅, 1,   NRF2↝, 1,   NRF2∅, 2,   Prx↓, 1,   PrxI↓, 1,   ROS↓, 12,   ROS↑, 69,   ROS⇅, 4,   SOD↓, 1,   SOD↑, 2,   SOD1↑, 1,   SOD2↓, 3,   Trx↓, 2,   Trx1↑, 1,   ox-Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   compI↓, 1,   compII↓, 1,   compIV↓, 1,   EGF↓, 1,   ETC↓, 2,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 10,   OCR↑, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ACC↑, 1,   ALAT↓, 1,   AMPK↑, 8,   ATP↓, 7,   ATP↑, 1,   CAIX/CA9↓, 1,   ECAR↓, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↓, 1,   GlutMet↓, 2,   Glycolysis↓, 9,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   H2S↑, 1,   HK2↓, 2,   lactateProd↓, 3,   LDHA↓, 1,   NAD↑, 1,   NADPH↓, 1,   NADPH↑, 2,   PFK↓, 1,   PKM2↑, 1,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 2,   TCA↓, 2,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 2,   Apoptosis?, 2,   Apoptosis↓, 1,   Apoptosis↑, 54,   BAD↑, 2,   Bak↑, 2,   BAX↓, 3,   BAX↑, 28,   Bax:Bcl2↑, 4,   Bcl-2↓, 24,   Bcl-2↑, 2,   Bcl-xL↓, 2,   BID↑, 1,   BIM↑, 3,   BNIP3↑, 2,   Casp↑, 10,   Casp↝, 1,   cl‑Casp↑, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp12↑, 1,   Casp3↑, 22,   cl‑Casp3↑, 3,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 7,   proCasp8↑, 1,   Casp9↑, 16,   cl‑Casp9↑, 2,   proCasp9↓, 1,   proCasp9↑, 1,   cFLIP↓, 4,   Cyt‑c↑, 23,   Diablo↑, 2,   DR5↓, 1,   DR5↑, 7,   Fas↑, 5,   FasL↑, 1,   Ferroptosis↑, 4,   GranB/GZMB↝, 1,   GSDMD↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 4,   Mcl-1↓, 2,   MDM2↓, 3,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p38↓, 2,   p38↑, 6,   p‑p38↓, 1,   Perforin↝, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 7,   TNFR 1↑, 1,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 2,   XIAP↓, 6,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 50,   Akt↑, 2,   p‑Akt↓, 7,   Akt2↓, 1,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 1,   p‑cMET↑, 1,   p‑CREB↑, 1,   EGFR↓, 10,   p‑EGFR↓, 1,   ERK↓, 9,   ERK↑, 3,   p‑ERK↓, 2,   p‑ERK↑, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   Hippo↝, 1,   HRAS↓, 1,   IKKα↓, 1,   JAK↓, 2,   JAK2↓, 2,   JNK↓, 1,   JNK↑, 5,   p‑JNK↑, 1,   MAP2K1/MEK1↓, 1,   MAPK↓, 9,   MAPK↑, 7,   MAPK↝, 1,   MARK4↓, 1,   MKK4↓, 1,   mTOR↓, 28,   mTOR↝, 1,   p‑mTOR↓, 1,   p70S6↓, 1,   P70S6K↓, 3,   PI3K↓, 47,   PI3K↑, 1,   p‑PI3K↓, 2,   p‑PI3K↑, 1,   PI3K/Akt↓, 1,   PKCδ↓, 3,   PTEN↓, 2,   PTEN↑, 6,   Raf↓, 1,   RAS↓, 3,   RAS↑, 1,   RET↓, 1,   RIP1↓, 1,   Sp1/3/4↓, 5,   STAT↓, 2,   STAT3↓, 18,   STAT3↑, 1,   p‑STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   ATF4↑, 3,   cJun↓, 4,   cMyc↓, 8,   DNMTs↓, 4,   EZH2↓, 1,   FOXM1↓, 1,   FOXO1↓, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   ac‑H3↓, 1,   ac‑H4↓, 1,   HATs↓, 1,   HDAC↓, 6,   HDAC1↓, 4,   HDAC2↓, 4,   HDAC3↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-19b↓, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   Myc↓, 1,   OCT4↓, 2,   other?, 1,   other↓, 3,   other↑, 4,   other↝, 2,   RUNX2↓, 1,   SOX2↓, 2,   SOX4↓, 1,   SOX9↓, 1,   tumCV?, 1,   tumCV↓, 10,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 7,   eIF2α↓, 1,   eIF2α↑, 3,   ER Stress↑, 18,   GRP78/BiP↑, 3,   HSP27↓, 4,   HSP70/HSPA5↓, 4,   HSP72↓, 1,   HSP90↓, 5,   HSPs↑, 1,   IRE1↑, 1,   NQO2↑, 1,   PERK↑, 3,   p‑PERK↑, 1,   UPR↑, 5,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 5,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 3,   p62↑, 1,   TumAuto↓, 1,   TumAuto↑, 10,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 9,   DNArepair↓, 1,   hTERT/TERT↓, 1,   P53↓, 2,   P53↑, 25,   P53↝, 1,   p‑P53↑, 3,   PARP↑, 5,   cl‑PARP↓, 1,   cl‑PARP↑, 15,   PARP1↑, 1,   PCNA↓, 7,   POLD1↓, 1,   Telomerase↓, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 7,   CDK2↓, 12,   CDK4↓, 13,   CDK6↓, 5,   CDK6↑, 1,   CHK1↓, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 20,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 5,   cycE/CCNE↑, 1,   Ki-67↓, 8,   mitA↑, 1,   P21↑, 18,   p27/CDKN1B↑, 4,   pRB↓, 1,   Securin↓, 1,   TumCCA↑, 54,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 1,   BMPs↑, 3,   CD133↓, 1,   CD133↑, 1,   cFos↓, 3,   CSCs?, 1,   CSCs↓, 8,   Diff↑, 1,   Gli↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1?, 1,   IGF-1↓, 1,   Ki-67↓, 8,   mTORC1↓, 2,   Nanog↓, 3,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH↑, 1,   NOTCH1↓, 4,   Shh↓, 1,   STAT1↓, 1,   TumCG↓, 14,   TumCG↑, 1,   TumCP↓, 38,   TumCP↑, 1,   Wnt↓, 14,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AP-1↑, 1,   BACH1↓, 1,   Ca+2↑, 5,   Ca+2↝, 2,   i-Ca+2↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 13,   EMT↓, 19,   EMT↝, 1,   FAK↓, 2,   FAK↑, 1,   p‑FAK↓, 1,   Fibronectin↓, 2,   KRAS↓, 2,   LAMs↓, 1,   LEF1↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 2,   MET↑, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 19,   MMP2↑, 1,   MMP3↓, 3,   MMP7↓, 4,   MMP9↓, 22,   MMP9↑, 1,   MMPs↓, 11,   N-cadherin↓, 10,   PDGF↓, 1,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 3,   Smad1↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 5,   TET1↑, 1,   TGF-β↓, 6,   TGF-β1↓, 1,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI↓, 22,   TumCMig↓, 19,   TumMeta↓, 19,   TumMeta↑, 2,   Twist↓, 5,   uPA↓, 8,   Vim?, 1,   Vim↓, 11,   Zeb1↓, 3,   β-catenin/ZEB1↓, 16,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 23,   CD31/PECAM-1↓, 1,   eNOS↓, 1,   HIF-1↓, 3,   Hif1a↓, 20,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VEGF↓, 31,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 1,   EPR↑, 1,   GLUT4↓, 1,   MMP↓, 25,   MPT↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD25+↑, 1,   CD4+↑, 1,   CD44↓, 3,   CD47↓, 1,   CD8+↑, 3,   COX1↓, 1,   COX2/PTGS2↓, 18,   CXCc↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 4,   DR4↑, 4,   Eos↑, 1,   FOXP3↑, 2,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 3,   IL1↓, 3,   IL12↓, 1,   IL1β↓, 3,   IL1β↑, 1,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL6↓, 11,   IL8↓, 5,   Imm↑, 3,   Imm↝, 2,   INF-γ↑, 1,   Inflam↓, 9,   Inflam↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 37,   NF-kB↑, 3,   NK cell↑, 2,   NLRP3↓, 1,   NLRP3↑, 3,   p65↓, 2,   PD-1↓, 2,   PD-L1↓, 4,   PGE2↓, 8,   PSA↓, 3,   RAGE↓, 1,   T-Cell↑, 2,   TCF↓, 2,   Th1 response↑, 2,   Th2↑, 1,   TLR4↓, 1,   TNF-α↓, 8,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER-α36↓, 2,   Estro↝, 1,   FGF21↓, 1,   PPARγ↓, 2,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 4,   ChemoSen↑, 50,   CYP1A1↓, 1,   Dose↓, 1,   Dose↑, 4,   Dose↝, 11,   eff↓, 2,   eff↑, 23,   eff↝, 3,   eff∅, 1,   Half-Life↑, 1,   Half-Life↝, 4,   MDR1↓, 3,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 12,   selectivity?, 1,   selectivity↑, 19,   selectivity∅, 1,   Synergy↑, 34,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 1,   AR↓, 1,   AST↓, 1,   BP↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 10,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 11,   KRAS↓, 2,   Myc↓, 1,   PD-L1↓, 4,   PSA↓, 3,   RAGE↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 16,   AntiCan∅, 1,   antiNeop↑, 1,   AntiTum↑, 8,   Appetite↑, 1,   cardioP↑, 4,   CardioT↓, 1,   chemoP↑, 24,   chemoPv↑, 5,   ChemoSideEff↓, 3,   cognitive↑, 1,   fatigue↓, 1,   hepatoP↑, 3,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↓, 1,   OS↑, 1,   Pain↓, 2,   PFS↑, 1,   QoL↑, 3,   radioP↑, 12,   Remission↑, 1,   RenoP↑, 5,   Risk↓, 3,   Risk↑, 1,   Sleep↑, 2,   toxicity↓, 5,   toxicity↝, 3,   toxicity∅, 1,   TumVol↓, 5,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 3,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 576

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3,   antiOx↓, 4,   antiOx↑, 173,   ARE↓, 1,   ARE↑, 15,   Bil↓, 1,   Bil↑, 2,   Catalase↓, 1,   Catalase↑, 104,   Catalase↝, 1,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 6,   GCLC↝, 1,   GCLM↑, 5,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 75,   GPx↝, 1,   GPx1↑, 3,   GPx4↑, 12,   GSH↓, 3,   GSH↑, 133,   GSH/GSSG↓, 1,   GSH/GSSG↑, 3,   GSR↓, 2,   GSR↑, 10,   GSS↑, 2,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 15,   H2O2↓, 8,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 2,   HNE↓, 1,   HNE↑, 1,   HO-1?, 2,   HO-1↓, 3,   HO-1↑, 202,   HO-1⇅, 1,   HO-2↓, 1,   hyperG↓, 1,   hyperG↝, 1,   Iron↓, 3,   i-Iron↓, 3,   Keap1↓, 22,   Keap1↑, 1,   Keap1↝, 2,   ox-Keap1↑, 1,   lipid-P↓, 72,   lipid-P↑, 2,   mt-lipid-P↓, 1,   MDA↓, 114,   MDA↑, 1,   MPO↓, 20,   MPO↑, 1,   NOX↓, 3,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 7,   NQO1↑, 53,   NQO1↝, 2,   Nrf1↑, 3,   NRF2↓, 1,   NRF2↑, 440,   NRF2⇅, 1,   p‑NRF2↑, 2,   ONOO↓, 1,   Prx↑, 3,   RNS↓, 4,   ROS?, 1,   ROS↓, 292,   ROS↑, 8,   ROS⇅, 4,   ROS∅, 2,   mt-ROS?, 1,   mt-ROS↓, 2,   selenoP↑, 1,   SOD?, 1,   SOD↓, 1,   SOD↑, 157,   SOD↝, 1,   SOD1↑, 10,   SOD2↓, 1,   SOD2↑, 6,   TAC↑, 24,   TBARS↓, 6,   Thiols↑, 1,   TOS↓, 1,   Trx↓, 1,   Trx↑, 7,   Trx1↑, 6,   TrxR↑, 3,   TrxR1↑, 3,   UCPs↑, 1,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 2,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 15,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 3,   FIS1↓, 1,   Insulin↑, 1,   MFN2↑, 2,   mitResp↑, 2,   mtDam↓, 17,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↑, 9,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 2,   SIRT3↑, 4,   TFAM↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   3MST/MPST↑, 1,   5LO↓, 5,   ACC↓, 1,   Acetyl-CoA↑, 1,   ACSL4↓, 3,   ALAT↓, 31,   ALDOC↑, 1,   AMPK↓, 1,   AMPK↑, 25,   p‑AMPK↑, 3,   ATP↓, 1,   ATP↑, 15,   Buty↑, 1,   cAMP↑, 3,   CBS↑, 1,   CRM↑, 3,   cytoP450↓, 1,   DGAT1↓, 1,   FABP4↓, 1,   FAO↓, 1,   FASN↓, 3,   G6PD↑, 2,   GAPDH↑, 1,   glucose↓, 4,   glucose↑, 2,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 6,   Glycolysis↑, 3,   GSK‐3β↓, 24,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 6,   H2S↑, 2,   HK2↓, 1,   HK2↑, 2,   HMG-CoA↓, 1,   LDHA↓, 1,   LDL↓, 12,   lipoGen↓, 1,   NAD↓, 1,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 11,   NADPH↑, 8,   NADPH∅, 1,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 2,   PKM2↑, 1,   PONs↑, 1,   SCFAs↑, 2,   SIRT1↓, 2,   SIRT1↑, 23,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↓, 4,   Apoptosis↓, 47,   Apoptosis↑, 1,   ASC↓, 1,   ASK1↓, 1,   BAX↓, 21,   BAX↑, 3,   Bax:Bcl2↓, 7,   Bcl-2↓, 4,   Bcl-2↑, 20,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 1,   Casp1↓, 4,   proCasp1↓, 1,   Casp12↓, 2,   Casp3↓, 36,   Casp3↑, 1,   cl‑Casp3↓, 9,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 12,   Casp9↑, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 8,   Cyt‑c↑, 2,   Cyt‑c∅, 1,   Fas↓, 2,   Ferroptosis↓, 19,   GranB/GZMB↓, 1,   iNOS↓, 49,   iNOS↑, 1,   necrosis↓, 1,   p38↓, 5,   p38↑, 1,   p‑p38↓, 3,   Pyro↓, 2,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   Akt↑, 28,   Akt↝, 1,   p‑Akt↑, 6,   e-Akt↑, 1,   AMPKα↑, 2,   CREB↑, 3,   p‑CREB↑, 3,   ERK↓, 10,   ERK↑, 10,   p‑ERK↓, 2,   p‑ERK↑, 3,   e-ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   IκB↑, 1,   JAK↓, 2,   JAK2↓, 1,   JAK2↑, 1,   JNK↓, 9,   JNK↑, 1,   p‑JNK↓, 6,   p‑JNK↑, 1,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 26,   MAPK↑, 4,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 2,   Mst1↓, 1,   mTOR↓, 8,   mTOR↑, 5,   p‑mTOR↓, 3,   PDGFR-BB↓, 1,   PFKFB2↓, 1,   PI3K↓, 5,   PI3K↑, 23,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↓, 2,   PKCδ↑, 3,   PP2A↑, 2,   PTEN↓, 3,   p‑PTEN↑, 1,   PTP1B↓, 1,   RIP1↓, 1,   STAT↓, 4,   STAT3↓, 8,   STAT3↑, 1,   STAT3↝, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF2↑, 1,   ATF4↓, 4,   ATF4↑, 1,   cJun↓, 3,   p‑cJun↓, 2,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 2,   DNMTs↓, 1,   FOXO↑, 1,   FOXO3↑, 3,   HDAC?, 1,   HDAC↓, 3,   HDAC↑, 1,   HDAC2↓, 1,   miR-34a↓, 1,   other↓, 5,   other↑, 9,   other↝, 11,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 9,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 15,   GRP78/BiP↓, 9,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 7,   HSP70/HSPA5↝, 1,   HSPs↑, 3,   IRE1↓, 1,   NQO2↑, 1,   PERK↓, 1,   UPR↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   ATG7↓, 1,   autophagy↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 1,   LC3s↓, 1,   MitoP↓, 1,   MitoP↑, 3,   p62↓, 2,   p62↑, 6,   PARK2↑, 3,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 11,   P53↓, 3,   PARP↓, 1,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   PCNA↑, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   GADD45A↑, 1,   Ki-67↓, 2,   Ki-67↑, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   CEBPA↓, 1,   cFos↓, 1,   CHIP↑, 1,   Choline↑, 1,   Diff↓, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   Ki-67↓, 2,   Ki-67↑, 1,   mTORC1↓, 1,   Nestin↑, 1,   neuroG↑, 9,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 3,   Wnt↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 10,   AP-1↓, 3,   AP-1↑, 1,   mt-ATPase↑, 1,   Ca+2↓, 11,   Ca+2↑, 2,   Ca+2↝, 2,   i-Ca+2↓, 1,   cal2↓, 1,   Cartilage↑, 3,   COL1↓, 2,   COL1↑, 1,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 4,   MMP2↑, 1,   MMP9↓, 8,   MMP9↑, 1,   MMPs↓, 2,   MUC1↑, 1,   Na+↑, 1,   NFAT↓, 1,   p‑Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   SMAD3↓, 1,   p‑T-cadherin↓, 1,   TG2/TGase↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TGF-β1↓, 3,   TGF-β1↑, 2,   TIMP1↓, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 4,   TXNIP↑, 1,   uPA↑, 1,   Vim↓, 1,   α-SMA↓, 3,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   E-sel↓, 3,   ECM/TCF↑, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   Hif1a↓, 2,   Hif1a↑, 1,   NO↓, 34,   NO↑, 2,   TXA2↓, 1,   VCAM-1↓, 11,   VEGF↓, 5,   VEGF↑, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 2,   BBB↑, 41,   BBB↝, 1,   BBB∅, 2,   CLDN1↑, 2,   CLDN5↑, 1,   GastroP↑, 4,   GLUT1↑, 2,   GLUT2↑, 2,   GLUT3↑, 3,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   IBI↑, 5,   memfluid↑, 1,   MMP↓, 3,   MMP↑, 24,   MUC5AC↓, 1,   Na+↑, 1,   NHE3↑, 1,   OCLN↓, 1,   OCLN↑, 2,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 1,   TRPV3↑, 1,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   BALF-Infl↓, 1,   CB2 / CNR2↑, 2,   CCL11↓, 1,   CD25+↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 69,   COX2/PTGS2↑, 2,   CXCc↓, 1,   FOXP3↑, 2,   HCAR2↑, 1,   HMGB1↓, 4,   ICAM-1↓, 9,   IFN-γ↓, 8,   IFN-γ↑, 3,   IgE↓, 1,   IL1↓, 5,   IL10↓, 10,   IL10↑, 13,   IL12↓, 5,   IL12↑, 1,   IL17↓, 6,   IL18↓, 2,   IL1α↓, 1,   IL1β↓, 94,   IL2↓, 5,   IL2↑, 1,   IL22↓, 1,   IL23↓, 3,   IL33↓, 2,   IL4↓, 7,   IL4↑, 3,   IL5↓, 1,   IL6↓, 90,   IL6↑, 3,   IL8↓, 11,   Imm↓, 1,   Imm↑, 4,   Imm↝, 1,   INF-γ↓, 3,   Inflam↓, 220,   Inflam↑, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 11,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 3,   NeuroI↓, 8,   NF-kB↓, 136,   NF-kB↑, 3,   NK cell↑, 2,   NLRP3↓, 39,   NLRP3↑, 1,   NOD1↓, 1,   p65↓, 5,   PGE2↓, 21,   PGE2↑, 1,   RAGE↓, 3,   RANTES↓, 2,   Th2↓, 1,   TLR1↓, 1,   TLR2↓, 3,   TLR4↓, 28,   TLR4↑, 1,   TNF-α↓, 128,   TRAF1↓, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 5,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 1,   5HT↓, 1,   5HT↑, 6,   Ach↑, 9,   AChE↓, 43,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 7,   BDNF↓, 1,   BDNF↑, 44,   BDNF⇅, 1,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 8,   ChE↓, 1,   GABA↓, 1,   GABA↑, 2,   GDNF↑, 1,   MAOA↓, 7,   MAOB↓, 2,   NGF↑, 8,   PSD95↑, 6,   RELN↑, 1,   SNAP25↑, 3,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 4,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 9,   Aβ↓, 49,   Aβ42↓, 6,   BACE/β-secretase↓, 24,   IDE↑, 2,   PSEN1/PS1↓, 1,   tau↓, 11,   p‑tau↓, 19,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 3,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   AR↓, 1,   BNP↓, 1,   cortisol↓, 1,   CYP19↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 1,   GR↝, 1,   NR1H4↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 3,   PPARγ↑, 18,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 34,   BioAv↑, 46,   BioAv↝, 28,   BioEnh↑, 1,   ChemoSen↑, 3,   CompStab↓, 1,   CompStab↑, 2,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2C6↑, 1,   CYP2D1↑, 1,   CYP2E1↓, 2,   CYP3A2↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 38,   eff↓, 8,   eff↑, 35,   eff↝, 3,   GSTA1↑, 2,   GSTP1/GSTπ↓, 1,   GSTP1/GSTπ↑, 1,   Half-Life↓, 6,   Half-Life↑, 3,   Half-Life↝, 13,   MRP↓, 1,   P-gp/ABCB1↓, 1,   P450↑, 2,   selectivity↑, 2,   Synergy↑, 25,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 31,   ALB↑, 1,   ALP↓, 6,   AR↓, 1,   AST↓, 31,   BG↓, 2,   Bil↓, 1,   Bil↑, 2,   BloodF↑, 3,   BMD↑, 3,   BP↓, 8,   BP↝, 2,   BP∅, 1,   BUN?, 1,   BUN↓, 6,   CEA↓, 1,   colonLen↑, 2,   creat↓, 13,   CRP↓, 10,   Ferritin↑, 2,   IL6↓, 90,   IL6↑, 3,   IRes↑, 1,   IRes↝, 1,   LDH↓, 10,   LDH↑, 3,   NOS2↓, 3,   RAGE↓, 3,   SpO2↑, 1,   TC↓, 3,   TG/TAG↓, 3,   TMAO↓, 1,   Urea↓, 3,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 1,   Analgesic↑, 1,   AntiAge↑, 11,   antiAll?, 1,   antiAll↑, 17,   AntiArt↑, 5,   AntiCan↑, 19,   antiCG↑, 1,   AntiDiabetic↑, 16,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 8,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 71,   CardioT↓, 3,   chemoP↑, 19,   chemoPv↑, 2,   cognitive↓, 1,   cognitive↑, 81,   diuretic↑, 2,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 2,   hepatoP↑, 66,   Learn↑, 13,   memory↑, 74,   Mood↑, 4,   motorD↓, 1,   motorD↑, 10,   Mucositis↓, 1,   neuroP↑, 170,   NP/CIPN↓, 3,   Obesity↓, 17,   OS↑, 9,   Pain↓, 6,   QoL↓, 1,   QoL↑, 1,   radioP↑, 6,   RenoP↑, 34,   Risk↓, 2,   Sleep↑, 2,   Strength↑, 5,   Stress↓, 1,   Stroke↓, 17,   toxicity?, 1,   toxicity↓, 22,   toxicity⇅, 1,   toxicity↝, 6,   toxicity∅, 4,   Weight↓, 3,   Weight↑, 2,   Wound Healing↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 11,   AntiFungal↑, 3,   AntiP↑, 2,   AntiViral↑, 8,   Bacteria↓, 17,   Diar↓, 2,   GutMicro↑, 34,   Sepsis↓, 9,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 7,  
Total Targets: 742

Scientific Paper Hit Count for: NRF2, nuclear factor erythroid 2-related factor 2
23 Sulforaphane (mainly Broccoli)
20 Curcumin
15 Quercetin
15 Thymoquinone
13 Lycopene
13 Hydrogen Gas
12 Resveratrol
11 Luteolin
10 EGCG (Epigallocatechin Gallate)
10 Licochalcone A
10 Silymarin (Milk Thistle) silibinin
10 Shikonin
9 Alpha-Lipoic-Acid
9 Chemotherapy
9 isoorientin
8 doxorubicin
8 Baicalein
8 Morin
7 Selenite (Sodium)
7 Selenium
7 Carnosic acid
7 Rosmarinic acid
6 Cisplatin
6 Beta-Caryophyllene
6 Isoliquiritigenin
6 Isovitexin
6 Propolis -bee glue
5 Ashwagandha(Withaferin A)
5 Radiotherapy/Radiation
5 Boswellia (frankincense)
5 Chlorogenic acid
5 Fisetin
5 Honokiol
5 Hyperoside
5 isoquercitrin
5 Kaempferol
5 Pterostilbene
4 Allicin (mainly Garlic)
4 Apigenin (mainly Parsley)
4 Boron
4 Vitexin
4 Melatonin
4 Urolithin
3 Allyl isothiocyanate
3 Benzyl isothiocyanate
3 Phenethyl isothiocyanate
3 Betulinic acid
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Chrysin
3 Cichoric acid / Chicoric acid
3 Crocetin
3 Ferulic acid
3 Ginger/6-Shogaol/Gingerol
3 Linalool
3 Magnetic Fields
3 Mushroom Lion’s Mane, Hericium erinaceus
2 1,8-Cineole
2 Artemisinin
2 Astaxanthin
2 Berberine
2 Capsaicin
2 Thymol-Thymus vulgaris
2 methotrexate
2 Carvone
2 Chlorella (Chlorella vulgaris)
2 Cysteamine
2 Emodin
2 Gallic acid
2 Ginseng
2 Isorhamnetin
2 Licorice
2 Magnolol
2 Matrine
2 Moringa oleifera
2 5-fluorouracil
2 Methylsulfonylmethane
2 Nimbolide
2 Parthenolide
2 Selenium NanoParticles
2 Taurine
2 Vitamin C (Ascorbic Acid)
1 Silver-NanoParticles
1 Baicalin
1 Berbamine
1 Biochanin A
1 xanthohumol
1 Cannabidiol
1 buckwheat sprouts
1 Butyrate
1 Caffeic acid
1 Catechins
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Camu camu
1 chitosan
1 Cinnamon
1 Calorie Restriction Mimetics
1 Cucurbitacin
1 Spirulina(Arthrospira/Limnospira)
1 Cynaropicrin
1 diet Methionine-Restricted Diet
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Dandelion Root
1 Eugenol
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Ginkgo biloba
1 Geraniol
1 hydrogen sulfide
1 HydroxyCitric Acid
1 Isobavachalcone
1 Isothiocyanates
1 lambertianic acid
1 methylseleninic acid
1 Metformin
1 Moringin
1 Lemon Balm/Melissa officinalis
1 Zeolite
1 Oleuropein
1 HydroxyTyrosol
1 Purple Corn / Purple Maize
1 Phenolic Acids
1 Hydroxycinnamic-acid
1 Piperine
1 Piperlongumine
1 Polyphenols
1 irinotecan
1 Salvia miltiorrhiza
1 Terminalia bellirica
1 Vanillic Acid
1 Mung Bean Sprouts
1 Vitamin B1/Thiamine
1 Vitamin D3
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:226  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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