P53 Cancer Research Results

P53, P53-Guardian of the Genome: Click to Expand ⟱
Source: TCGA
Type: Proapototic
TP53 is the most commonly mutated gene in human cancer. TP53 is a gene that encodes for the p53 tumor suppressor protein ; TP73 (Chr.1p36.33) and TP63 (Chr.3q28) genes that encode transcription factors p73 and p63, respectively, are TP53 homologous structures.
p53 is a crucial tumor suppressor protein that plays a significant role in regulating the cell cycle, maintaining genomic stability, and preventing tumor formation. It is often referred to as the "guardian of the genome" due to its role in protecting cells from DNA damage and stress.
TP53 gene, which encodes the p53 protein, is one of the most frequently mutated genes in human cancers.
Overexpression of MDM2, an inhibitor of p53, can lead to decreased p53 activity even in the presence of wild-type p53.
In some cancers, particularly those with mutant p53, there may be an overexpression of the p53 protein.
Cancers with overexpression: Breast, lung, colorectal, overian, head and neck, Esophageal, bladder, pancreatic, and liver.
Scientific Papers found: Click to Expand⟱
6138- CHr,  Cisplatin,    Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: Probable role of p38MAPK and p53
- in-vivo, Nor, NA
*toxicity↝, eff↑, chemoP↑, *ROS↓, *MAPK↑, *P53↑, GSH↓,
7423- CS,    Prophylactic effects of Cynara scolymus L. leaf and flower hydroethanolic extracts against diethylnitrosamine/acetylaminoflourene-induced lung cancer in Wistar rats
- in-vivo, Nor, NA
*lipid-P↓, *GSTs↑, *GPx↑, *GSR↑, *SOD↑, *P53↑, *Bcl-2↑, *ROS↓,
1332- EMD,    Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway
- in-vivo, Nor, HepaRG
*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,
1318- EMD,    Aloe-emodin Induces Apoptosis in Human Liver HL-7702 Cells through Fas Death Pathway and the Mitochondrial Pathway by Generating Reactive Oxygen Species
- in-vitro, Nor, HL7702
*TumCCA↑, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↓, *Bax:Bcl2↑, *cl‑Casp3↑, *cl‑Casp8↑, *cl‑Casp9↑, *cl‑PARP↑,
8308- FS,  lign,    The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1
- in-vivo, BPH, NA
*eff↑, *other↝, *GPER↑, *TumCCA↑, *P53↑, *P21↑, *cycD1/CCND1↓,
8497- MAG,    Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway
- in-vitro, BC, MCF7
TumCP↓, Apoptosis↑, *TumCCA↑, *ROS↑, *MMP↓, *Cyt‑c↑, *AIF↑, *BAX↑, *P21↑, *P53↑, *Bcl-2↓, *CycB/CCNB1↓, *CDK1↓,
3807- mushLions,    Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging
- in-vivo, Park, NA
*AntiAge↑, *other↑, *NOS2↓, *COX2/PTGS2↓, *P53↑, *neuroP↑,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx↑, 1,   GSR↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   ROS↓, 2,   ROS↑, 3,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   Fas↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

MAPK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,   tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 7,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↑, 1,   P21↓, 1,   P21↑, 4,   TumCCA↑, 4,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GPER↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   neuroP↑, 1,   toxicity↝, 1,  
Total Targets: 43

Scientific Paper Hit Count for: P53, P53-Guardian of the Genome
2 Emodin
1 Chrysin
1 Cisplatin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Flaxseed/Linseed
1 SDG/lignans
1 Magnolol
1 Mushroom Lion’s Mane, Hericium erinaceus
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:236  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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