Bcl-xL Cancer Research Results
Bcl-xL, Bcl-xL: Click to Expand ⟱
| Source: |
| Type: pro-survival proteins |
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL.
BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype.
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Scientific Papers found: Click to Expand⟱
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
*BAD↓, *BAX↓, *Casp3↓, *Bcl-xL↑, *p‑Akt↑, *MMP9↓, *p‑ERK↑, *HIF-1↓, *ROS↓, *VEGF↑, *Ca+2↓, *SOD↑, *IL2↑, *p38↑, *HSP70/HSPA5↑, *Apoptosis↓, *ROS↓, *NO↓,
Showing Research Papers: 1 to 2 of 2
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
ROS↑, 1,
Cell Death(tgid=5) ⓘ
Casp3↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
Wnt↓, 1,
Migration(tgid=13) ⓘ
β-catenin/ZEB1↓, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
VEGF↓, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
NLRP3↑, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
ChemoSen↑, 1, selectivity↑, 1,
Functional Outcomes(tgid=23) ⓘ
chemoP↑, 1, QoL↑, 1, radioP↑, 1, TumVol↓, 1, TumW↓, 1,
Total Targets: 13
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 1, Catalase↑, 1, Fenton↓, 1, HO-1↑, 1, lipid-P↓, 1, MDA↓, 1, MPO↓, 1, NOX↓, 1, NOX4↓, 1, NRF2↑, 1, RNS↓, 1, ROS↓, 3, SOD↑, 2, TBARS↓, 1, VitE↓, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
NADPH↓, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↓, 2, BAD↓, 1, BAX↓, 1, Bcl-2↑, 1, Bcl-xL↑, 2, Casp3↓, 2, Casp9↓, 1, p38↑, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
Akt↑, 1, p‑Akt↑, 1, p‑ERK↑, 1, JAK2↑, 1, PI3K↑, 1, STAT3↑, 1,
Transcription & Epigenetics(tgid=7) ⓘ
tumCV↓, 1,
Protein Folding & ER Stress(tgid=8) ⓘ
HSP70/HSPA5↑, 1,
DNA Damage & Repair(tgid=10) ⓘ
DNAdam↓, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
TumCP↓, 1,
Migration(tgid=13) ⓘ
Ca+2↓, 1, MMP9↓, 1, TumCI↓, 1, TumCMig↓, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
HIF-1↓, 1, NO↓, 1, VEGF↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
CD25+↑, 1, CD4+↑, 1, FOXP3↑, 1, HMGB1↓, 1, IL10↑, 1, IL1β↓, 1, IL2↑, 1, IL4↑, 1, IL6↓, 1, Inflam↓, 1, M2 MC↑, 1, MCP1/CCL2↓, 1, NF-kB↓, 1, NLRP3↓, 1, PGE2↓, 1, TNF-α↓, 1, Treg lymp↝, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
Dose↓, 1, Dose↑, 1, Dose↝, 1, eff↑, 1,
Clinical Biomarkers(tgid=22) ⓘ
IL6↓, 1, SpO2↑, 1,
Functional Outcomes(tgid=23) ⓘ
antiAll↑, 1, OS↑, 1, Weight↑, 1,
Total Targets: 67
Scientific Paper Hit Count for: Bcl-xL, Bcl-xL
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:1 prod#:% Target#:28 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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