SOD Cancer Research Results

SOD, superoxide dismutase: Click to Expand ⟱
Source:
Type:
SOD, or superoxide dismutase, is an important antioxidant enzyme that plays a crucial role in protecting cells from oxidative stress. It catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide.
SOD Isoforms: There are three main isoforms of SOD:
SOD1 (cytosolic): Often found to be overexpressed in certain tumors, which may help cancer cells survive in oxidative environments.
SOD2 (mitochondrial): Plays a critical role in protecting mitochondria from oxidative damage. Its expression can be upregulated in some cancers, contributing to tumor growth and resistance to therapy.
SOD3 (extracellular): Its role in cancer is less well understood, but it may have implications in the tumor microenvironment and metastasis.
The expression levels of SOD can serve as a prognostic indicator in some cancers. For example, high levels of SOD expression have been associated with poor prognosis in certain types of tumors, potentially due to their role in promoting tumor cell survival and resistance to therapies.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
7980- AAS/EEAA,    Protective Effects of Annona Atemoya Extracts on Inflammation, Oxidative Stress, and Renal Function in Cadmium-Induced Nephrotoxicity in Wistar Rats
- in-vivo, Nor, NA
*creat↓, *SOD↑, *Catalase↑, *GPx↑, *TNF-α↓, *IL6↓, *RenoP↑, *Inflam↓, *ROS↓,
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
4385- AgNPs,    Hepatoprotective effect of engineered silver nanoparticles coated bioactive compounds against diethylnitrosamine induced hepatocarcinogenesis in experimental mice
- in-vitro, Liver, NA
hepatoP↑, *AST↓, *ALAT↓, *Catalase↑, *GPx↑, *GSTA1↑, *SOD↑,
2207- AgNPs,  TQ,    Protective effects of Nigella sativa L. seeds aqueous extract-based silver nanoparticles on sepsis-induced damages in rats
- in-vivo, Nor, NA
*eff↑, *RenoP↑, *hepatoP↑, *MDA↓, *SOD↑, *GSH↑, *TNF-α↓, *IL1β↓,
2205- AgNPs,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
2770- AL,    Allicin protects against renal ischemia–reperfusion injury by attenuating oxidative stress and apoptosis
- in-vivo, Nor, NA - in-vitro, Nor, NRK52E
*antiOx↑, *RenoP↑, *MDA↓, *SOD↑,
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
3439- ALA,    The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles
- in-vitro, Nor, NA
*ROS↓, *TAC↑, *eff↑, *SOD↑, *GPx↑, *Catalase↑, *GlucoseCon↑, *antiOx↑,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
7408- Amla,    Fresh Phyllanthus emblica (Amla) Fruit Supplementation Enhances Milk Fatty Acid Profiles and the Antioxidant Capacities of Milk and Blood in Dairy Cows
- Trial, Nor, NA
*Dose↝, *TAC↑, *SOD↑, *ALB↑, *ROS↓, *other↑,
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, CompStab↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
1562- Api,    Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway
- in-vitro, Vit, NA
*SOD↑, *Catalase↑, *GPx↑, *MDA↓, *NRF2↑, *toxicity∅,
3884- Api,    Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model
- in-vivo, AD, NA
*memory↑, *Aβ↓, *BACE/β-secretase↓, *antiOx↑, *BDNF↑, *p‑CREB↑, *p‑ERK↑, *ROS↓, *SOD↑, *GPx↑, *neuroP↑,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
2317- Api,    Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1α mediated oxidative stress
- in-vivo, Nor, NA
*hepatoP↑, *PKM2↓, *Hif1a↓, *MDA↓, *Catalase↓, *GSH↑, *SOD↑, *GPx↑, *TAC↑, *α-SMA↓, *Vim↓, *ROS↓,
3161- Ash,    Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
- in-vivo, Stroke, NA
*neuroP↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *NRF2↑, *HO-1↑,
3163- Ash,  Rad,    Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis
- in-vitro, Var, NA
*radioP↑, selectivity↑, *Casp3↓, *DNAdam↓, *ROS↓, *GSH↓, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *Prx↑, *ERK↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
5384- AsP,  MLT,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
5418- ASTX,    Astaxanthin supplementation mildly reduced oxidative stress and inflammation biomarkers: a systematic review and meta-analysis of randomized controlled trials
- Review, Nor, NA
*MDA↓, *SOD↑, *IL6↓, *ROS↓, *Inflam↓,
5419- ASTX,    Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiDiabetic↓, AntiCan↑, *lipid-P↓, TumCP↓, Apoptosis↑, TumCCA↑, *SOD↑, *PGE2↓, *NO↓, *IL8↓, *IFN-γ↓, *cardioP↑, *NF-kB↓, *TNF-α↓, *BioAv↑,
5420- ASTX,    A New Tailored Nanodroplet Carrier of Astaxanthin Can Improve Its Pharmacokinetic Profile and Antioxidant and Anti-Inflammatory Efficacies
- in-vivo, Nor, NA
*eff↑, *SOD↑, *BioAv↑,
5425- ASTX,    Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE/β-secretase↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
4276- BA,    Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
- in-vivo, Stroke, NA
*BDNF↑, *neuroP↑, *TrkB↑, *PI3K↑, *Akt↑, *MAPK↑, *ERK↑, *NO↓, *MDA↓, *SOD↑, *TNF-α↓, *IL1β↓, *IL6?,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2613- Ba,    Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *SOD↑, *Catalase↑, *GSH↑, *MAPK↓, *p‑JAK2↓, *p‑STAT3↓, *ALAT↓, *AST↓, *ROS↓, *antiOx↑,
1380- BBR,  doxoR,    treatment with ROS scavenger N-acetylcysteine (NAC) and JNK inhibitor SP600125 could partially attenuate apoptosis and DNA damage triggered by DCZ0358.
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
2758- BetA,    Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *SOD↑, *GSH↑, *p‑p38↓, *p‑JNK↓, *p‑ERK↓, *NRF2↑, *HO-1↑, *MAPK↓, *heparanase↑, *antiOx↑,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1/CCL2↓, MMP9↓, COX2/PTGS2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
2761- BetA,    Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
- in-vivo, Nor, NA
Insulin↓, IGF-1↓, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *antiOx?,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
9178- BITC,    Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats
- in-vivo, Nor, NA
*GastroP↑, *GSH↑, *SOD↑, *NO↑, *PGE2↑, *MDA↓, *TNF-α↓, *MPO↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *HSP70/HSPA5↑, *NF-kB↓, *Casp3↓, *Inflam↓, *ROS↓,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,
3690- BM,    Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease
- Review, AD, NA
*ROS↓, *5LO↓, *lipid-P↓, *GPx↑, *IronCh↑, *neuroP↑, *AChE↓, *memory↑, *toxicity↓, *SOD↑, *Catalase↑, *cognitive↑, *ChAT↑, *Ach↑, *BP↓,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *Synergy↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp/ABCB1↓, Synergy↑, other↝,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *Synergy↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,

Showing Research Papers: 1 to 50 of 390
Page 1 of 8 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 390

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   antiOx⇅, 1,   Catalase↓, 6,   Catalase↑, 4,   Fenton↑, 1,   GPx↓, 2,   GPx↑, 2,   GSH↓, 11,   GSH↑, 3,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 2,   H2O2↑, 2,   HO-1↓, 2,   HO-1↑, 6,   Iron↝, 1,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↓, 2,   MDA↑, 4,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 3,   NRF2↓, 6,   NRF2↑, 7,   ROS↓, 17,   ROS↑, 62,   ROS⇅, 3,   i-ROS↑, 1,   SOD?, 1,   SOD↓, 8,   SOD↑, 1,   SOD2↓, 3,   SOD2↑, 1,   Thiols↓, 1,   Trx1↑, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 2,   compIV↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 7,   OXPHOS↑, 1,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 4,   AMPK↓, 1,   AMPK↑, 2,   ATP↓, 3,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↑, 1,   FAO↑, 1,   FASN↓, 3,   glucose↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 9,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 3,   HK2↓, 4,   lactateProd↓, 4,   LDHA↓, 3,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PKM2↓, 3,   Pyruv↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 3,   TCA↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 5,   APAF1↑, 3,   Apoptosis↓, 2,   Apoptosis↑, 57,   ASC↓, 1,   BAD↓, 1,   BAD↑, 3,   Bak↓, 1,   Bak↑, 1,   BAX↓, 2,   BAX↑, 36,   Bax:Bcl2↑, 7,   Bcl-2↓, 34,   Bcl-2↑, 3,   Bcl-xL↓, 6,   BID↑, 2,   BIM↑, 1,   BNIP3↑, 1,   BOK↑, 1,   Casp↑, 10,   Casp↝, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3↑, 39,   cl‑Casp3↑, 4,   cl‑Casp3⇅, 1,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 13,   Casp9↑, 23,   cl‑Casp9↑, 2,   proCasp9↓, 1,   CellShr↑, 1,   Cyt‑c↑, 23,   mt-Cyt‑c↓, 1,   Diablo↑, 2,   DR5↑, 8,   FADD↑, 3,   Fas↑, 9,   FasL↑, 1,   Ferroptosis↑, 1,   GSDMD↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 2,   ICAD↓, 1,   iNOS↓, 4,   Mcl-1↓, 1,   MDM2↓, 3,   p‑MDM2↓, 1,   MOMP↑, 1,   NAIP↓, 1,   Necroptosis↑, 1,   p38↓, 1,   p38↑, 7,   p‑p38↑, 2,   pS2/TFF1↓, 1,   PUMA↑, 1,   survivin↓, 10,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 10,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 38,   Akt↑, 3,   p‑Akt↓, 13,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 1,   CIP2A↓, 1,   cSrc↓, 1,   EGFR↓, 6,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 13,   p‑ERK↓, 3,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 3,   IKKα↓, 1,   JAK↓, 2,   JAK2↓, 2,   JNK↓, 2,   JNK↑, 6,   p‑JNK↓, 1,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 8,   MAPK↑, 7,   MAPK↝, 1,   p‑MAPK↑, 1,   MARK4↓, 1,   MKK4↓, 1,   mTOR↓, 20,   mTOR↝, 1,   p‑mTOR↓, 2,   P70S6K↓, 1,   PI3K↓, 36,   PI3K↑, 1,   p‑PI3K↓, 3,   p‑PI3K↑, 1,   PKCδ↓, 3,   PTEN↓, 1,   PTEN↑, 7,   RAS↓, 3,   Sp1/3/4↓, 2,   p‑Src↓, 1,   STAT↓, 3,   STAT3↓, 23,   STAT3↑, 1,   p‑STAT3↓, 3,   p‑STAT3↑, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   cJun↓, 1,   cMyc↓, 9,   cMyc↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 2,   EZH2↓, 3,   FOXM1↓, 1,   FOXO1↓, 2,   FOXO1↑, 2,   FOXO3↓, 1,   FOXO3↝, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↓, 1,   H4↓, 1,   HATs↓, 1,   HDAC↓, 6,   HDAC1↓, 3,   HDAC2↓, 5,   HDAC3↓, 3,   HDAC6↓, 1,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-21↓, 1,   miR-25-5p↓, 1,   miR-27a-3p↓, 1,   miR-34a↓, 2,   miR-34a↑, 1,   OCT4↓, 3,   other?, 1,   other↓, 1,   other↑, 3,   other↝, 3,   PAX2↓, 1,   SOX2↓, 2,   SOX9?, 1,   SOX9↓, 1,   tumCV?, 1,   tumCV↓, 10,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 11,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   HSPs↑, 1,   NQO2↑, 1,   PERK↑, 2,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 8,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 18,   DNArepair↑, 1,   hTERT/TERT↓, 3,   p16↑, 1,   P53↓, 1,   P53↑, 31,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 6,   cl‑PARP↓, 1,   cl‑PARP↑, 11,   PCNA↓, 12,   Telomerase↓, 2,   TOP1↓, 2,   TOP2↓, 3,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 3,   p‑CDK1↓, 1,   CDK2↓, 10,   CDK2↑, 1,   CDK4↓, 13,   CDK6↓, 1,   CDK6↑, 1,   CDKN1C/p57↑, 1,   CHK1↓, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 7,   cycD1/CCND1↓, 21,   cycE/CCNE↓, 3,   E2Fs↓, 1,   GADD45A↑, 1,   Ki-67↓, 13,   P21↓, 1,   P21↑, 18,   p27/CDKN1B↑, 5,   pRB↓, 1,   p‑RB1↓, 1,   TumCCA↑, 52,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 2,   CD34↓, 1,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 6,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 3,   HH↓, 2,   IGF-1↓, 4,   IGFBP3↑, 1,   Ki-67↓, 13,   mTORC1↓, 1,   Nanog↓, 2,   NOTCH↓, 3,   NOTCH↑, 1,   NOTCH1↓, 4,   NOTCH1↑, 1,   Shh↓, 1,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 16,   TumCG↑, 2,   TumCP↓, 34,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 2,   Ca+2↑, 4,   i-Ca+2↑, 1,   cal2↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   COL1↓, 1,   E-cadherin↓, 6,   E-cadherin↑, 12,   EMT↓, 18,   EMT↝, 1,   EpCAM↓, 1,   F-actin↓, 1,   FAK↓, 3,   FAK↑, 1,   p‑FAK↓, 2,   Fibronectin↓, 1,   ITGB1↓, 1,   KRAS↓, 2,   LAMs↓, 1,   LRP1↑, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 22,   MMP3↓, 1,   MMP9↓, 29,   MMP9↑, 2,   MMPs↓, 5,   N-cadherin↓, 11,   PDGF↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 2,   ROCK1↓, 1,   Slug?, 1,   Slug↓, 2,   Smad1↓, 1,   Smad1↑, 1,   Snail?, 1,   Snail↓, 3,   TET1↑, 1,   TGF-β↓, 3,   TIMP1↑, 4,   TIMP2↓, 1,   TIMP2↑, 4,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 16,   TumCMig↓, 18,   TumMeta↓, 19,   TumMeta↑, 2,   Twist↓, 6,   Tyro3↓, 1,   uPA↓, 1,   uPAR↓, 1,   Vim↓, 10,   Vim↑, 1,   Zeb1↓, 2,   ZEB2↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 22,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 1,   Hif1a↓, 18,   NO↓, 1,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 32,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 2,   GLUT1↓, 2,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP↓, 21,   TRPM7↓, 1,   TRPV1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 2,   CD47↓, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 26,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCL12↓, 1,   CXCR3↓, 1,   CXCR4↓, 5,   DR4↑, 2,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 5,   IFN-γ↓, 1,   IL1↓, 2,   IL10↑, 1,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL6↓, 15,   IL8↓, 3,   Imm↑, 5,   Inflam↓, 11,   Inflam↑, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 38,   NF-kB↑, 2,   p‑NF-kB↑, 1,   NK cell↑, 5,   NLRP3↓, 2,   NLRP3↑, 3,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 3,   PGE1↓, 1,   PGE2↓, 7,   PSA↓, 1,   RAGE↓, 1,   Resistin↓, 1,   T-Cell↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 2,   TNF-α↓, 13,   TNF-α↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   ER-α36↓, 1,   ERα/ESR1↓, 1,   Estro↝, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARγ↓, 1,   PPARγ↑, 2,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 10,   BioAv↑, 9,   BioAv↝, 4,   chemoR↓, 1,   ChemoSen↑, 50,   CompStab↓, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A2↓, 1,   DDS↑, 1,   Dose↑, 2,   Dose↝, 17,   Dose∅, 1,   eff↓, 3,   eff↑, 19,   eff↝, 2,   eff∅, 1,   GSTM1↑, 1,   Half-Life↓, 1,   Half-Life↝, 3,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 6,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   P450↓, 1,   RadioS↑, 12,   selectivity↑, 23,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 36,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 3,   ALAT↓, 4,   ALP↓, 1,   AR↓, 5,   AST↓, 2,   BMD↑, 1,   BP↓, 1,   BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 3,   creat↓, 1,   CRP↓, 2,   EGFR↓, 6,   EGFR↑, 2,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 3,   FOXM1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 3,   IL6↓, 15,   KRAS↓, 2,   LDH↓, 1,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 3,   PSA↓, 1,   RAGE↓, 1,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 26,   antiNeop↑, 1,   AntiTum↑, 8,   Appetite↑, 1,   BowelM↑, 1,   cachexia↓, 2,   cardioP↑, 9,   chemoP↑, 21,   chemoPv↑, 3,   ChemoSideEff↓, 2,   cognitive↑, 4,   fatigue↓, 1,   hepatoP↑, 10,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 1,   OS↑, 7,   Pain↓, 3,   PFS↑, 1,   QoL↑, 4,   radioP↑, 10,   RenoP↑, 4,   Risk↓, 6,   Sleep↑, 2,   toxicity↓, 5,   toxicity↝, 2,   TumVol↓, 7,   TumW↓, 2,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 4,  
Total Targets: 587

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 3,   antiOx?, 2,   antiOx↓, 7,   antiOx↑, 175,   ARE↑, 7,   Bil↓, 2,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 220,   Copper↓, 1,   Fenton↓, 4,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 4,   GPx↑, 153,   GPx∅, 1,   GPx1↑, 2,   GPx4↓, 1,   GPx4↑, 9,   GSH↓, 1,   GSH↑, 184,   GSH∅, 1,   GSH/GSSG↑, 3,   GSR↓, 3,   GSR↑, 29,   GSSG↓, 4,   GSTs↓, 3,   GSTs↑, 35,   H2O2↓, 11,   H2O2↑, 1,   HDL↑, 7,   HNE↓, 2,   HO-1?, 2,   HO-1↓, 2,   HO-1↑, 111,   HO-1⇅, 1,   Iron↓, 4,   i-Iron↓, 2,   Keap1↓, 9,   Keap1↑, 1,   lipid-P↓, 119,   lipid-P↑, 1,   MDA?, 1,   MDA↓, 175,   MDA↑, 5,   MPO↓, 20,   MPO↑, 2,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 5,   NQO1↑, 30,   NQO1↝, 1,   Nrf1↑, 3,   NRF2↓, 3,   NRF2↑, 161,   Prx↑, 4,   RNS↓, 4,   ROMO1↑, 1,   ROS?, 3,   ROS↓, 307,   ROS↑, 2,   ROS⇅, 3,   mt-ROS↓, 3,   RPM↝, 1,   SAM-e↑, 1,   selenoP↑, 1,   SOD↑, 396,   mt-SOD↑, 1,   SOD1↑, 4,   SOD2↑, 4,   TAC↑, 26,   TBARS↓, 10,   TBARS↑, 1,   Thiols↑, 4,   TOS↓, 1,   Trx↑, 3,   Trx1↑, 3,   TrxR↑, 1,   uricA↓, 3,   VitC↑, 9,   VitE↓, 1,   VitE↑, 6,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   FTL↓, 1,   IronCh↑, 13,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 2,   EGF↓, 1,   EGF↑, 1,   FIS1↓, 1,   Insulin↓, 1,   Insulin↑, 2,   MFN2↑, 2,   mtDam↓, 8,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   OXPHOS↓, 1,   PGC-1α↑, 4,   SIRT3↑, 3,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 7,   ACC↓, 1,   ACSL4↓, 2,   adiP↓, 1,   ALAT↓, 46,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 17,   ATP↓, 1,   ATP↑, 13,   ATP↝, 1,   Buty↑, 1,   cAMP↑, 2,   CPT1A↑, 1,   CRM↑, 2,   cytoP450↓, 1,   DGAT1↓, 1,   FASN↓, 2,   FFA/NEFA↓, 1,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 7,   glucose↝, 2,   GlucoseCon↑, 4,   Glycolysis↑, 2,   GSK‐3β↓, 20,   GSK‐3β↑, 3,   p‑GSK‐3β↑, 3,   H2S↑, 3,   HK2↑, 3,   HMG-CoA↓, 2,   IDH1↑, 1,   LDHA↑, 1,   LDL↓, 16,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 2,   NAD↝, 1,   NADPH↓, 7,   NADPH↑, 6,   PFK↓, 1,   PFK↑, 1,   PFKL↑, 1,   PFKM↑, 1,   PFKP↑, 1,   PGC1A↑, 1,   PKM2↓, 1,   PKM2↑, 2,   PLA2↓, 1,   PONs↑, 1,   SCD1↓, 1,   SCFAs↑, 2,   SIRT1↓, 1,   SIRT1↑, 21,   SREBP1/SREBF1↓, 3,   SREBP1/SREBF1↑, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 37,   ASC↓, 1,   ASK1↓, 1,   BAD↓, 3,   BAX↓, 33,   BAX↑, 2,   Bax:Bcl2↓, 3,   Bcl-2↓, 4,   Bcl-2↑, 28,   Bcl-xL↑, 2,   Casp↓, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3↓, 47,   Casp3↑, 2,   cl‑Casp3↓, 5,   proCasp3↑, 1,   Casp8↓, 3,   cl‑Casp8↑, 1,   Casp9↓, 16,   Casp9↑, 2,   cl‑Casp9↓, 1,   Cyt‑c↓, 10,   Fas↓, 2,   Ferroptosis↓, 11,   GranB/GZMB↓, 1,   GSDMD↓, 1,   iNOS↓, 52,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 6,   p38↑, 2,   p‑p38↓, 3,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 8,   Akt↑, 18,   p‑Akt↓, 1,   p‑Akt↑, 7,   AMPKα↑, 1,   CREB↑, 7,   p‑CREB↑, 5,   ERK↓, 8,   ERK↑, 7,   p‑ERK↓, 2,   p‑ERK↑, 3,   HGF/c-Met↑, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   IκB?, 1,   JAK2↓, 2,   JAK2↑, 3,   p‑JAK2↓, 1,   JNK↓, 13,   JNK↑, 1,   p‑JNK↓, 5,   MAPK↓, 21,   MAPK↑, 4,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 2,   Mst1↓, 1,   mTOR↓, 6,   mTOR↑, 6,   p‑mTOR↓, 2,   p‑mTOR↑, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 17,   PI3K↝, 1,   p‑PI3K↓, 1,   PKA↑, 1,   PKCδ↑, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 2,   STAT↓, 2,   STAT3?, 1,   STAT3↓, 4,   STAT3↑, 4,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF2↑, 1,   ATF4↓, 4,   ATF4↑, 1,   cJun↓, 2,   p‑cJun↓, 1,   cMyc↓, 1,   FOXO1↑, 1,   FOXO1↝, 1,   FOXO3↑, 1,   HDAC↓, 1,   HDAC2↓, 1,   miR-34a↓, 1,   other?, 2,   other↓, 8,   other↑, 22,   other↝, 5,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 11,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 15,   GRP78/BiP↓, 12,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP70/HSPA5↑, 11,   HSPs↑, 1,   IRE1↓, 2,   PDI↓, 1,   PERK↓, 2,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 4,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↓, 1,   LC3II↑, 1,   MitoP↑, 3,   p62↓, 1,   p62↑, 2,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 14,   P53↓, 2,   P53↑, 1,   PARP↓, 1,   cl‑PARP↓, 1,   PCNA↓, 1,   PCNA↑, 1,   SIRT6↑, 1,   γH2AX↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 2,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   Diff↝, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 2,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 5,   NOTCH1↑, 1,   TumCP↓, 2,   tyrosinase↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AP-1↓, 4,   AP-1↑, 1,   BACH1↓, 1,   Ca+2↓, 14,   Ca+2↝, 1,   i-Ca+2↓, 1,   cal2↓, 1,   Cartilage↑, 1,   COL1↓, 4,   COL1↑, 2,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP2↓, 4,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 9,   MMP9↑, 1,   MMPs↓, 5,   MUC1↑, 2,   ROCK1↓, 1,   serineP↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 6,   TGF-β↑, 2,   TGF-β1↓, 2,   TGF-β1↑, 2,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 4,   Vim↓, 2,   α-SMA↓, 8,   α-SMA↑, 1,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 2,   E-sel↓, 3,   eNOS↓, 1,   eNOS↑, 2,   p‑eNOS↑, 1,   HIF-1↓, 2,   Hif1a↓, 3,   LOX1↓, 2,   NO?, 1,   NO↓, 44,   NO↑, 7,   TXA2↓, 1,   VCAM-1↓, 9,   VEGF↓, 2,   VEGF↑, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 36,   BBB↝, 1,   CLDN1↓, 1,   EPR↑, 1,   GastroP↑, 7,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   IBI↑, 6,   MMP↓, 2,   MMP↑, 27,   MMP↝, 2,   NHE3↑, 1,   OCLN↓, 1,   OCLN↑, 1,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 3,   TRPM7⇅, 1,   TRPV3↑, 1,   ZO-1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

BALF-Infl↓, 2,   BALF-Lym↓, 1,   CB2 / CNR2↑, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 80,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCL15↓, 1,   Eos↓, 1,   FOXP3↑, 1,   HMGB1↓, 5,   ICAM-1↓, 11,   IFN-γ↓, 10,   IFN-γ↑, 2,   IgE↓, 2,   IL1↓, 3,   IL10↓, 11,   IL10↑, 20,   IL12↓, 5,   IL12↑, 1,   IL13↓, 2,   IL17↓, 6,   IL18↓, 1,   IL1β↓, 94,   IL1β↑, 1,   IL2↓, 7,   IL2↑, 2,   IL22↓, 1,   IL23↓, 2,   IL33↓, 2,   IL4↓, 12,   IL4↑, 4,   IL5↓, 3,   IL6?, 1,   IL6↓, 92,   IL6↑, 4,   IL8↓, 12,   IL8↑, 1,   Imm↓, 1,   Imm↑, 13,   INF-γ↓, 3,   Inflam↓, 197,   Inflam↑, 2,   IP-10/CXCL-10↓, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   MCP1/CCL2↓, 11,   MIP‑1α/CCL3↓, 1,   MyD88↓, 3,   NeuroI↓, 5,   Neut↓, 1,   NF-kB↓, 107,   NF-kB↑, 1,   NK cell↑, 2,   NLRP3↓, 21,   NLRP3↑, 2,   p65↓, 2,   PGE2↓, 29,   PGE2↑, 3,   RAGE↓, 4,   RANTES↓, 1,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↓, 1,   Th2↑, 2,   TLR1↓, 1,   TLR2↓, 3,   TLR4↓, 22,   TNF-α↓, 136,   TNF-α↑, 2,   TRAF1↓, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 2,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 6,   Ach↑, 12,   AChE↓, 56,   AChE↑, 1,   AChE↝, 1,   ADAM10↑, 2,   BChE↓, 9,   BDNF↓, 1,   BDNF↑, 37,   BDNF⇅, 1,   ChAT↑, 10,   ChE↓, 1,   EndoR↑, 1,   GABA↑, 4,   GABA↝, 1,   MAOA↓, 5,   MAOB↓, 1,   monoA↓, 1,   monoA↑, 2,   NGF↑, 7,   PSD95↑, 4,   RELN↑, 1,   SNAP25↑, 1,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 6,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   APOE4↓, 1,   APP↓, 6,   cl‑APP↑, 1,   Aβ↓, 58,   Aβ42↓, 5,   BACE/β-secretase↓, 22,   IDE↑, 1,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   tau↓, 14,   p‑tau↓, 15,   XO↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AHR↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   BNP↓, 1,   cortisol↓, 1,   CYP19↓, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 4,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 10,   RAAS↓, 1,   testos↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 36,   BioAv↑, 67,   BioAv↝, 33,   BioEnh↑, 5,   ChemoSen↑, 2,   CompStab↑, 3,   CYP2D6↓, 1,   CYP2E1↓, 4,   CYP3A2↓, 1,   Dose?, 4,   Dose↓, 1,   Dose↑, 6,   Dose↝, 53,   eff↓, 4,   eff↑, 39,   eff↝, 4,   GSTA1↓, 1,   GSTA1↑, 8,   Half-Life↓, 6,   Half-Life↑, 4,   Half-Life↝, 13,   P-gp/ABCB1↓, 3,   P450↓, 3,   P450↑, 2,   P450↝, 1,   selectivity↑, 3,   Synergy↑, 26,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 46,   ALB↑, 2,   ALB↝, 1,   ALP↓, 14,   anemia↓, 1,   AST↓, 49,   BG↓, 5,   Bil↓, 2,   Bil↑, 2,   BloodF↑, 3,   BMD↑, 3,   BP↓, 10,   BP↝, 1,   BUN?, 1,   BUN↓, 5,   Calcium↑, 1,   CEA↓, 2,   CK/CK-MB↓, 1,   creat↓, 13,   CRP↓, 12,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   hs-CRP↓, 1,   IL6?, 1,   IL6↓, 92,   IL6↑, 4,   IRes↝, 1,   LDH↓, 17,   LDH↑, 2,   Mag↑, 1,   NOS2↓, 2,   RAGE↓, 4,   RBC↑, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 5,   Urea↓, 4,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 3,   AirwayM↓, 1,   Analgesic↑, 1,   AntiAge↑, 11,   antiAll?, 1,   antiAll↑, 22,   AntiArt↑, 5,   AntiCan↑, 21,   antiCG↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 27,   antiM↑, 1,   AntiMyl↑, 1,   antiPs↑, 2,   antiPy↑, 1,   AntiTum↑, 3,   ANXi↓, 1,   BOLD↑, 1,   cardioP?, 1,   cardioP↑, 71,   CardioT↓, 2,   chemoP↑, 18,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 78,   diuretic↑, 2,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 82,   Learn↑, 9,   memory↑, 77,   Mood?, 1,   Mood↑, 2,   motorD↓, 1,   motorD↑, 12,   Mucositis↓, 2,   neuroP↑, 165,   NP/CIPN↓, 2,   Obesity↓, 15,   OS↑, 6,   Pain↓, 7,   QoL↑, 1,   radioP↑, 13,   RenoP↓, 1,   RenoP↑, 34,   Risk↓, 9,   Sleep↑, 3,   Strength↑, 4,   Stress↓, 1,   Stroke↓, 14,   toxicity?, 1,   toxicity↓, 26,   toxicity↑, 1,   toxicity↝, 10,   toxicity∅, 6,   Weight↓, 2,   Weight↑, 3,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 10,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 15,   AntiFungal↑, 6,   AntiP↑, 1,   AntiViral↑, 5,   Bacteria↓, 16,   Diar↓, 2,   GutMicro↑, 37,   Inf↓, 1,   Sepsis↓, 11,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 3,   Ingr↝, 5,   Phen↑, 1,   QC↑, 1,  
Total Targets: 703

Scientific Paper Hit Count for: SOD, superoxide dismutase
23 Thymoquinone
15 Curcumin
13 Hydrogen Gas
12 Luteolin
12 Silymarin (Milk Thistle) silibinin
10 Quercetin
9 EGCG (Epigallocatechin Gallate)
9 Magnetic Fields
9 Moringa oleifera
8 Silver-NanoParticles
8 Carvacrol
8 Ferulic acid
8 Lycopene
8 Rosmarinic acid
8 Selenium NanoParticles
7 Boron
7 Crocetin
7 Resveratrol
6 Chlorogenic acid
6 Chrysin
6 Propolis -bee glue
6 Kaempferol
6 Shikonin
5 Radiotherapy/Radiation
5 Melatonin
5 Chemotherapy
5 isoorientin
5 Pterostilbene
5 Urolithin
4 Alpha-Lipoic-Acid
4 Apigenin (mainly Parsley)
4 Astaxanthin
4 doxorubicin
4 Betulinic acid
4 Cisplatin
4 Hyperoside
4 Isoliquiritigenin
4 L-Theanine
4 Morin
4 Sulforaphane (mainly Broccoli)
3 Allicin (mainly Garlic)
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Ashwagandha(Withaferin A)
3 Baicalein
3 Berberine
3 Selenium
3 Boswellia (frankincense)
3 buckwheat sprouts
3 Date Fruit Extract
3 Emodin
3 Fisetin
3 Lemon Balm/Melissa officinalis
3 Matrine
3 Vitamin C (Ascorbic Acid)
2 Ascorbyl Palmitate
2 Baicalin
2 Biochanin A
2 Benzyl isothiocyanate
2 α-Bisabolol / Chamomile oil
2 Carnosic acid
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Coenzyme Q10
2 Carvone
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Spirulina(Arthrospira/Limnospira)
2 D-limonene
2 Dandelion Root
2 Eugenol
2 Shilajit/Fulvic Acid
2 Gallic acid
2 Isovitexin
2 Licorice
2 Lactoferrin/Talactoferrin
2 Magnolol
2 Magnetic Field Rotating
2 Methylsulfonylmethane
2 Piperine
2 Rutin
2 chitosan
2 Turmerones
2 Vitexin
1 1,8-Cineole
1 Annona atemoya Seed Extract
1 Anthocyanins
1 Anethole/trans-Anethole
1 Aloe anthraquinones
1 Beta-Caryophyllene
1 Phenethyl isothiocyanate
1 Allyl isothiocyanate
1 Bacopa monnieri
1 borneol
1 Beetroot
1 Caffeic acid
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carnosine
1 Celastrol
1 Citicoline, CDP-Choline
1 Cucurbitacin
1 Chlorella (Chlorella vulgaris)
1 Docosahexaenoic Acid
1 diet Methionine-Restricted Diet
1 Ginkgo biloba-EGb 761
1 Exercise
1 Fucoidan
1 Ginkgo biloba
1 Salvia officinalis
1 Geraniol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 HydroxyCitric Acid
1 Hibiscus sabdariffa
1 Honokiol
1 Huperzine A/Huperzia serrata
1 Inositol
1 isoquercitrin
1 lambertianic acid
1 Licochalcone A
1 SDG/lignans
1 Linalool
1 Mung Bean Sprouts
1 Methyl Jasmonate
1 Magnesium
1 Methylene blue
1 Zeolite
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Oleuropein
1 HydroxyTyrosol
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 EMF
1 polyethylene glycol
1 Sesame seeds and Oil
1 Shankhpushpi
1 Selenite (Sodium)
1 Taurine
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:298  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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