STAT3 Cancer Research Results

STAT3, Signal transducer and activator of transcription 3: Click to Expand ⟱
Source:
Type: Oncogene
Stat3 (Signal Transducer and Activator of Transcription 3) is a transcription factor that plays a crucial role in various cellular processes, including cell growth, survival, differentiation, and immune response.
Stat3 is frequently found to be constitutively activated in many types of cancers, including breast, prostate, lung, and head and neck cancers. (associated with poor prognosis and reduced survival.)

-STAT3 is typically activated by cytokines (such as IL-6) and growth factors binding to their respective receptors.
-Activated STAT3 upregulates the expression of genes that promote cell cycle progression (e.g., cyclin D1) and anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL).
Scientific Papers found: Click to Expand⟱
2676- BBR,    Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress
- in-vivo, Nor, NA - in-vivo, CardioV, NA
*cardioP↑, *ROS↓, *ER Stress↓, *p‑PERK↓, *p‑eIF2α↓, *ATF4↓, CHOP/DDIT3↓, *JAK2↑, *STAT3↑, *UPR↓,
6829- EMD,    Molecular Mechanisms of Action of Emodin: As an Anti-Cardiovascular Disease Drug
- Review, Nor, NA
*diuretic↑, *Bacteria↓, *AntiViral↑, *Inflam↓, AntiCan↑, *cardioP↑, *NF-kB↓, *TNF-α↓, *IL1β↓, *NO↑, *eNOS↑, *PPARγ↑, *Casp9↓, *Casp3↓, *GSDMD↓, *Bcl-2↑, *STAT3↑, *ATP↑, *SOD↑, *GSH↑, *HDAC2↓, *SIRT3↑, ROS↑, PCNA↓, P53↑, cMyc↓,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
9064- L-THE,    L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice
- in-vivo, Stroke, NA
*Stroke↓, *Bcl-2↑, *BAX↓, *Casp3↓, *ROS?, *MDA?, *NO?, *TAC↑, *GSH↑, *SOD↑, *cardioP↑, *JAK2↑, *STAT3↑,
8526- Matr,    A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
- Review, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
8555- Matr,    Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
- Review, Var, NA
*AntiTum↑, *Inflam↓, *Analgesic↑, *AntiViral↑, *Imm↑, *PI3K↑, *Akt↑, *mTOR↑, TumAuto↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, E-cadherin↑, Vim↓, MMP2↓, MMP9↓, Snail↓, Slug↓, PTEN↑, TumCP↓, TumCMig↓, TumCI↓, ChemoSen↑, ROS↑, uPA↓, p‑ERK↓, cachexia↓, antiD↑, GSK‐3β↓, LC3B-II↑, p62↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, FOXO1↑, FOXO3↑, FOXO4↑, PARP↑, BIM↑, Bcl-2↓, survivin↓, miR-21↓, *HOTAIR↑, *p‑Akt↑, *p‑STAT3↑, *STAT3↑, *ROS↓, Wnt↓, β-catenin/ZEB1↓, NOTCH1↓, JAG1↓, HES1↓, BioAv↝, toxicity↝,
3040- SK,    Pharmacological Properties of Shikonin – A Review of Literature since 2002
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA
*Half-Life↝, *BioAv↓, *BioAv↑, *BioAv↑, *Inflam↓, *TNF-α↓, *other↑, *MPO↓, *COX2/PTGS2↓, *NF-kB↑, *STAT3↑, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *Catalase↑, *GPx↑, *Bcl-2↑, *BAX↓, cardioP↑, AntiCan↑, NF-kB↓, ROS↑, PKM2↓, TumCCA↑, Necroptosis↑, Apoptosis↑, DNAdam↑, MMP↓, Cyt‑c↑, LDH↝,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 1,   GSK‐3β↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Bcl-2↓, 2,   BIM↑, 1,   Casp↑, 1,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Necroptosis↑, 1,   p38↓, 1,   survivin↓, 2,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   p‑ERK↓, 1,   JAK2↓, 1,   mTOR↓, 2,   PI3K↓, 2,   PTEN↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   FOXO1↑, 1,   FOXO3↑, 1,   FOXO4↑, 1,   HES1↓, 1,   miR-21↓, 1,   OCT4↓, 1,   SOX2↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3B-II↑, 1,   p62↓, 2,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   PARP↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

JAG1↓, 1,   NOTCH1↓, 1,   TumCP↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   MMP2↓, 2,   MMP9↓, 2,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   NF-kB↓, 2,   NLRP3↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 3,   P-gp/ABCB1↓, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   LDH↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   antiD↑, 1,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 1,   QoL↑, 1,   radioP↑, 1,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 76

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 2,   Fenton↓, 1,   GPx↑, 1,   GSH↑, 2,   HO-1↑, 1,   lipid-P↓, 1,   MDA?, 1,   MDA↓, 1,   MPO↓, 2,   NOX↓, 1,   NOX4↓, 1,   NRF2?, 1,   NRF2↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 5,   SOD↑, 4,   TAC↑, 1,   TBARS↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   ATP↑, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↑, 4,   Bcl-xL↑, 1,   Casp3↓, 3,   Casp9↓, 2,   GSDMD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   p‑Akt↑, 1,   JAK2↑, 4,   mTOR↑, 1,   PI3K↑, 2,   STAT3↑, 7,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   HDAC2↓, 1,   HOTAIR↑, 1,   other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

p‑eIF2α↓, 1,   ER Stress↓, 1,   p‑PERK↓, 1,   UPR↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

eNOS↑, 1,   NO?, 1,   NO↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 1,   FOXP3↑, 1,   HMGB1↓, 2,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 3,   IL4↑, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 5,   M2 MC↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 3,   NF-kB↑, 1,   NLRP3↓, 1,   PGE2↓, 1,   TNF-α↓, 5,   Treg lymp↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 3,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   antiAll↑, 2,   AntiArt↑, 1,   AntiCan↑, 1,   AntiTum↑, 1,   cardioP↑, 4,   diuretic↑, 1,   hepatoP↑, 1,   neuroP↑, 2,   OS↑, 1,   Stroke↓, 1,   toxicity↝, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 3,   Bacteria↓, 2,  
Total Targets: 106

Scientific Paper Hit Count for: STAT3, Signal transducer and activator of transcription 3
2 Matrine
1 Berberine
1 Emodin
1 Hydrogen Gas
1 L-Theanine
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:373  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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