Ki-67 Cancer Research Results

Ki-67, Ki-67 protein: Click to Expand ⟱
Source:
Type: proliferation marker
A high Ki-67 proliferation index means many cells are dividing quickly and that the cancer is likely to grow and spread.
Markers of proliferation index (Ki-67)

• Ki-67 serves primarily as a proliferation marker: higher levels are generally indicative of aggressive disease and poorer outcomes across many cancer types.
• While Ki-67 itself is not considered a driver of tumorigenesis, its expression mirrors the high proliferative activity associated with protumoral behavior.
• It is widely used in clinical practice to aid in tumor grading, prognostication, and treatment planning.
Scientific Papers found: Click to Expand⟱
6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,
8220- LCA,    Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation
- in-vivo, AD, NA
*Dose↝, *memory↑, *PSD95↑, *Ki-67↑, *GLUT1↑, *Aβ↓, *Aβ42↓, *Inflam↓, *TREM2↓, *cognitive↑,
8959- mushLions,  BM,  L-THE,    Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
- Review, AD, NA
*Synergy↑, *neuroP↑, *INF-γ↑, *BDNF↑, *Synergy↑, *Synergy↑, *BBB↑, *Ki-67↑, *p‑CREB↑, *tau↓, *GSK‐3β↓, *Wnt↑, *β-catenin/ZEB1↑, *memory↑, *Sleep↑, *p‑NF-kB↓, *ROS↓, *Stress↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 2,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 3,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   ATP↑, 1,   glucose↓, 1,   GSK‐3β↓, 2,   PFK↓, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑CREB↑, 1,   PI3K↑, 1,   PP2A↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

SOX2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↑, 3,   Nestin↑, 1,   NOTCH1↑, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

β-catenin/ZEB1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

INF-γ↑, 1,   Inflam↓, 2,   p‑NF-kB↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

TREM2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 2,   MAOA↓, 1,   MAOB↓, 1,   NGF↑, 1,   PSD95↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   Aβ42↓, 1,   tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 2,   Dose↝, 1,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 2,   memory↑, 3,   neuroP↑, 2,   Obesity↓, 1,   Sleep↑, 1,   Stress↓, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  
Total Targets: 61

Scientific Paper Hit Count for: Ki-67, Ki-67 protein
1 Centella asiatica / Gotu kola → asiaticoside
1 Licochalcone A
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Bacopa monnieri
1 L-Theanine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:425  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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