Casp8 Cancer Research Results
Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱
| Source: CGL-Driver Genes |
| Type: TSG |
Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.
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Scientific Papers found: Click to Expand⟱
*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,
*TumCCA↑, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↓, *Bax:Bcl2↑, *cl‑Casp3↑, *cl‑Casp8↑, *cl‑Casp9↑, *cl‑PARP↑,
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, Synergy↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
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in-vivo, |
Melanoma, |
NA |
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- |
in-vitro, |
Melanoma, |
A431 |
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*cl‑Casp8↑, *PARP↑, *P21↑, tumCV↓, TumCP↓, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK4↓, CDC2↓, P21↑, Apoptosis↑,
Showing Research Papers: 1 to 4 of 4
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
ROS↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
CDC2↓, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↑, 1,
Transcription & Epigenetics(tgid=7) ⓘ
tumCV↓, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
CDK4↓, 1, cycA1/CCNA1↓, 1, CycB/CCNB1↓, 1, Ki-67↓, 1, P21↑, 1, TumCCA↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
Ki-67↓, 1, TumCG↓, 1, TumCP↓, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
VEGF↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
eff↑, 1, eff↝, 1, selectivity↑, 1, Synergy↑, 1,
Functional Outcomes(tgid=23) ⓘ
chemoP↑, 1, radioP↑, 1,
Total Targets: 20
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
HO-1↑, 1, NRF2↑, 1, ROS↓, 1, ROS↑, 2, SOD↑, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↓, 1, Bax:Bcl2↓, 1, Bax:Bcl2↑, 2, Casp3↑, 1, cl‑Casp3↑, 1, Casp8↑, 1, cl‑Casp8↑, 3, Casp9↑, 1, cl‑Casp9↑, 1, Fas↑, 2,
Transcription & Epigenetics(tgid=7) ⓘ
tumCV↓, 1,
DNA Damage & Repair(tgid=10) ⓘ
P53↑, 2, PARP↑, 1, cl‑PARP↑, 2,
Cell Cycle & Senescence(tgid=11) ⓘ
CDK2↓, 1, cycA1/CCNA1↓, 1, cycE/CCNE↑, 1, P21↓, 1, P21↑, 3, TumCCA↑, 2,
Barriers & Transport(tgid=15) ⓘ
MMP↓, 2,
Immune & Inflammatory Signaling(tgid=16) ⓘ
IL6↓, 1, Inflam↓, 1, TNF-α↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
Half-Life↓, 1, selectivity↑, 1,
Clinical Biomarkers(tgid=22) ⓘ
IL6↓, 1,
Functional Outcomes(tgid=23) ⓘ
cardioP↑, 1, chemoP↑, 2, hepatoP↑, 1, radioP↑, 1, RenoP↑, 1,
Total Targets: 37
Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:1 prod#:% Target#:44 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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