Catalase Cancer Research Results

Catalase, Catalase: Click to Expand ⟱
Source:
Type:
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Caspase-1 may have both tumorigenic or antitumorigenic effects on cancer development and progression, but it depends on the type of inflammasome, methodology, and cancer.
Catalase is an enzyme found in nearly all living cells exposed to oxygen. Its primary role is to protect cells from oxidative damage by catalyzing the conversion of hydrogen peroxide (H₂O₂), a potentially damaging byproduct of metabolism, into water (H₂O) and oxygen (O₂). This detoxification process is crucial because excess H₂O₂ can lead to the formation of reactive oxygen species (ROS) that damage proteins, lipids, and DNA.

Catalase and Cancer
Oxidative Stress and Cancer:
Cancer cells often experience increased levels of oxidative stress due to rapid proliferation and metabolic changes. This stress can lead to DNA damage, promoting tumorigenesis.
Catalase helps mitigate oxidative stress, and its expression can influence the survival and proliferation of cancer cells.
Expression Levels in Different Cancers:
Overexpression: In some cancers, such as breast cancer and certain types of leukemia, catalase may be overexpressed. This overexpression can help cancer cells survive in oxidative environments, potentially leading to more aggressive tumor behavior.
Downregulation: Conversely, in other cancers, such as colorectal cancer, reduced catalase expression has been observed. This downregulation can lead to increased oxidative stress, contributing to tumor progression and metastasis.
Prognostic Implications:
Survival Rates: Studies have shown that high levels of catalase expression can be associated with poor prognosis in certain cancers, as it may enable cancer cells to resist apoptosis (programmed cell death) induced by oxidative stress.

Some types of cancer cells have been reported to exhibit lower catalase activity, possibly increasing their vulnerability to oxidative damage under certain conditions. This vulnerability has even been exploited in some therapeutic strategies (for example, approaches that generate excess H₂O₂ or other ROS specifically targeting cancer cells have been researched).
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
7980- AAS/EEAA,    Protective Effects of Annona Atemoya Extracts on Inflammation, Oxidative Stress, and Renal Function in Cadmium-Induced Nephrotoxicity in Wistar Rats
- in-vivo, Nor, NA
*creat↓, *SOD↑, *Catalase↑, *GPx↑, *TNF-α↓, *IL6↓, *RenoP↑, *Inflam↓, *ROS↓,
1406- AgNPs,    The antioxidant effects of silver, gold, and zinc oxide nanoparticles on male mice in in vivo condition
- in-vivo, Nor, NA
*ROS↓, *GPx↑, *Catalase↑, *ROS↑,
4385- AgNPs,    Hepatoprotective effect of engineered silver nanoparticles coated bioactive compounds against diethylnitrosamine induced hepatocarcinogenesis in experimental mice
- in-vitro, Liver, NA
hepatoP↑, *AST↓, *ALAT↓, *Catalase↑, *GPx↑, *GSTA1↑, *SOD↑,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2205- AgNPs,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- Review, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3439- ALA,    The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles
- in-vitro, Nor, NA
*ROS↓, *TAC↑, *eff↑, *SOD↑, *GPx↑, *Catalase↑, *GlucoseCon↑, *antiOx↑,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
1562- Api,    Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway
- in-vitro, Vit, NA
*SOD↑, *Catalase↑, *GPx↑, *MDA↓, *NRF2↑, *toxicity∅,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
3385- ART/DHA,    Interaction of artemisinin protects the activity of antioxidant enzyme catalase: A biophysical study
- Study, Nor, NA
*NF-kB↑, *Catalase↑, *antiAll↑,
3163- Ash,  Rad,    Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis
- in-vitro, Var, NA
*radioP↑, selectivity↑, *Casp3↓, *DNAdam↓, *ROS↓, *GSH↓, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *Prx↑, *ERK↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
5384- AsP,  MLT,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
2613- Ba,    Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *SOD↑, *Catalase↑, *GSH↑, *MAPK↓, *p‑JAK2↓, *p‑STAT3↓, *ALAT↓, *AST↓, *ROS↓, *antiOx↑,
2294- Ba,    Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes
- in-vivo, Nor, NA
*Catalase↑, *ROS↓, *cardioP↑, *FOXO3?,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
2725- BetA,    Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice
- in-vivo, Nor, NA
*RenoP↑, *SOD?, *Catalase↑, *GSH↑, *ROS↓, *MDA↓, *IL1β↓, *TNF-α↓, *IL10↓, *IL6↑, *NRF2↑,
2731- BetA,    Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
- Review, GBM, NA - Review, Park, NA - Review, AD, NA
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1/CCL2↓, MMP9↓, COX2/PTGS2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
2761- BetA,    Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
- in-vivo, Nor, NA
Insulin↓, IGF-1↓, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *antiOx?,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,
3690- BM,    Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease
- Review, AD, NA
*ROS↓, *5LO↓, *lipid-P↓, *GPx↑, *IronCh↑, *neuroP↑, *AChE↓, *memory↑, *toxicity↓, *SOD↑, *Catalase↑, *cognitive↑, *ChAT↑, *Ach↑, *BP↓,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *Synergy↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
9287- BR, BRJ,    Anticancer and Anti-Inflammatory Potential of Betalains: A Systematic Review on Preclinical Studies
- Review, Var, NA
tumCV↓, TumCP↓, Apoptosis↑, Casp↑, TumCCA↑, Inflam↓, NF-kB↓, CCN2/CTGF↓, IL6↓, COX2/PTGS2↓, iNOS↓, toxicity↓, *ROS↓, ROS↑, *SOD↑, *Catalase↑, PI3K↓, Akt↓, mTOR↓, DNMT1↓, DNMT3A↓, DNMT3B↓, HDAC6↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6553- BSB,    Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms
- Review, Nor, NA
*ROS↓, *Inflam↓, *Inf↓, *neuroP↑, *RNS↓, *MDA↓, *GSH↑, *MPO↓, *SOD↑, *Catalase↑, *Bcl-2↑, *BAX↓, *P53↓, *APAF1↓, *Casp3↓, *Casp9↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *ERK↓, *JNK↓, *NF-kB↓, *p38↓, *cognitive↑, *BChE↓,
7944- BuckWS,    Extracts from Tartary Buckwheat Sprouts Restricts Oxidative Injury Induced by Hydrogen Peroxide in HepG2 by Upregulating the Redox System
- in-vitro, Nor, HepG2
*ROS↓, *MMP↑, *TAC↑, *SOD↑, *Catalase↑, *GSTA1↑, *NRF2↑, *NQO1↑, *HO-1↑,
7949- BuckWS,    Producing High-Quality Buckwheat Sprouts: The Combined Effects of Melatonin and UV-B Treatment
- Study, Nor, NA
*eff↑, *SOD↑, *GPx↑, *Catalase↑, *other↑,
5755- CA,    Caffeic Acid as a Promising Natural Feed Additive: Advancing Sustainable Aquaculture
- Review, Nor, NA
*Imm↑, *Inflam↓, *Bacteria↓, *eff↑, *ROS↓, *MDA↓, *Catalase↑, *GSH↑, *TAC↑, *NF-kB↓, *NLRP3↓, *Synergy↑, *AST↓, *ALAT↓, *SOD↑, *GSTA1↑,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp/ABCB1↓, ChemoSen↑,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5909- CAR,    Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
*AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *GSR↑, *hepatoP↑, *lipid-P↓,
5901- CAR,    Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement
- Review, Stroke, NA
*neuroP↑, *ROS↓, *MDA↓, *4-HNE↓, *SOD↑, *Catalase↑, *GPx↑, *Apoptosis↓, *cl‑Casp3↓, *TRPM7⇅, *BBB↓, *TRPM7↓,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,

Showing Research Papers: 1 to 50 of 270
Page 1 of 6 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 270

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   antiOx⇅, 1,   Catalase↓, 6,   Catalase↑, 2,   GPx↓, 1,   GPx↑, 2,   GSH↓, 8,   GSH↑, 2,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 1,   H2O2↑, 2,   HO-1↓, 2,   HO-1↑, 5,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↓, 2,   MDA↑, 2,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 1,   NRF2↓, 6,   NRF2↑, 8,   ROS↓, 15,   ROS↑, 54,   ROS⇅, 2,   i-ROS↑, 1,   SOD?, 1,   SOD↓, 6,   SOD↑, 2,   SOD2↓, 3,   Thiols↓, 1,   Trx1↑, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 4,   compIV↓, 1,   Insulin↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 6,   OXPHOS↑, 2,   PGC-1α↑, 1,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↓, 1,   AMPK↑, 3,   ATP↓, 4,   ATP↑, 1,   mt-ATP↓, 1,   CAIX/CA9↑, 1,   FAO↑, 1,   FASN↓, 3,   glucose↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 8,   GSK‐3β↓, 3,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 3,   HK2↓, 4,   lactateProd↓, 4,   LDHA↓, 3,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PKM2↓, 3,   Pyruv↓, 1,   SCD1↓, 1,   SIRT1↓, 3,   SIRT1↑, 2,   TCA↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 4,   APAF1↑, 4,   Apoptosis↓, 3,   Apoptosis↑, 52,   ASC↓, 1,   BAD↓, 1,   BAD↑, 3,   Bak↓, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 34,   Bax:Bcl2↑, 4,   Bcl-2↓, 32,   Bcl-2↑, 1,   Bcl-xL↓, 7,   BID↑, 1,   BIM↑, 1,   BNIP3↑, 1,   Casp↑, 9,   Casp↝, 1,   Casp1↓, 1,   Casp3↓, 1,   Casp3↑, 41,   cl‑Casp3↑, 4,   cl‑Casp3⇅, 1,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 14,   Casp9↑, 27,   cl‑Casp9↑, 3,   proCasp9↓, 1,   CellShr↑, 1,   cFLIP↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 20,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 6,   FADD↑, 2,   Fas↑, 7,   FasL↑, 2,   GSDMD↑, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 4,   Mcl-1↓, 1,   MDM2↓, 3,   p‑MDM2↓, 1,   MOMP↑, 1,   Necroptosis↑, 1,   p38↓, 1,   p38↑, 5,   p‑p38↑, 2,   PUMA↑, 1,   survivin↓, 8,   TNFR 1↑, 1,   TumCD↑, 5,   XIAP↓, 6,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 37,   Akt↑, 2,   p‑Akt↓, 11,   AMPKα↑, 1,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 8,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 13,   ERK↑, 1,   p‑ERK↓, 3,   HER2/EBBR2↓, 3,   HGF/c-Met↓, 1,   IGF-1R↓, 2,   IKKα↓, 1,   JAK↓, 1,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 6,   p‑JNK↓, 1,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 6,   MAPK↑, 9,   MAPK↝, 1,   p‑MAPK↑, 1,   MARK4↓, 1,   MKK4↓, 1,   mTOR↓, 23,   mTOR↝, 1,   p‑mTOR↓, 2,   P70S6K↓, 2,   PI3K↓, 31,   PI3K↑, 1,   p‑PI3K↓, 2,   p‑PI3K↑, 1,   PI3K/Akt↓, 1,   PKCδ↓, 3,   PTEN↓, 1,   PTEN↑, 5,   RAS↓, 5,   RAS↑, 1,   Sp1/3/4↓, 3,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 19,   p‑STAT3↓, 4,   p‑STAT3↑, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 2,   cJun↓, 1,   cMyc↓, 6,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMT3B↓, 1,   DNMTs↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HATs↓, 1,   HDAC↓, 6,   HDAC1↓, 3,   HDAC2↓, 5,   HDAC3↓, 3,   HDAC6↓, 1,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   OCT4↓, 3,   other?, 1,   other↓, 2,   other↑, 4,   PAX2↓, 1,   SOX2↓, 1,   SOX9↓, 1,   tumCV?, 1,   tumCV↓, 11,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 10,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   HSPs↑, 2,   NQO2↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 16,   DNArepair↑, 1,   hTERT/TERT↓, 2,   P53↓, 1,   P53↑, 26,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 7,   cl‑PARP↓, 1,   cl‑PARP↑, 12,   PCNA↓, 8,   Telomerase↓, 2,   TOP1↓, 3,   TOP2↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 2,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 10,   CDK2↑, 1,   CDK4↓, 14,   CDK6↓, 2,   CDK6↑, 1,   CDKN1C/p57↑, 1,   ChrCon↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 18,   cycE/CCNE↓, 3,   E2Fs↓, 2,   Ki-67↓, 8,   mitA↑, 1,   P21↓, 1,   P21↑, 15,   p27/CDKN1B↑, 6,   pRB↓, 1,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 50,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   CD34↓, 1,   cFos↑, 1,   CSCs↓, 4,   EIF4E↓, 1,   FGF↓, 1,   Gli1↓, 3,   HH↓, 1,   IGF-1↓, 4,   IGFBP3↑, 1,   Ki-67↓, 8,   mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 4,   NOTCH1↑, 1,   Shh↓, 2,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 10,   TumCG↑, 2,   TumCP↓, 32,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   AXL↓, 2,   BACH1↓, 1,   Ca+2↑, 4,   i-Ca+2↑, 2,   cal2↓, 1,   CCN2/CTGF↓, 1,   Cdc42↓, 1,   COL1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 12,   EMT↓, 17,   EMT↑, 1,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   LAMs↓, 1,   LRP1↑, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 2,   MMP13↓, 2,   MMP2↓, 20,   MMP3↓, 2,   MMP9↓, 24,   MMP9↑, 2,   MMPs↓, 9,   N-cadherin↓, 10,   PDGF↓, 1,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 3,   Rho↝, 1,   ROCK1↓, 2,   Slug?, 1,   Slug↓, 2,   Smad1↓, 1,   Smad1↑, 1,   Snail?, 1,   Snail↓, 4,   TET1↑, 1,   TGF-β↓, 3,   TIMP1↑, 3,   TIMP2↓, 1,   TIMP2↑, 4,   TIMP3↑, 1,   TumCI↓, 19,   TumCMig↓, 19,   TumMeta↓, 19,   TumMeta↑, 1,   Twist↓, 7,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 9,   Vim↑, 1,   Zeb1↓, 3,   ZEB2↓, 1,   β-catenin/ZEB1↓, 7,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 22,   angioG↑, 1,   CD31/PECAM-1↓, 2,   HIF-1↓, 2,   Hif1a↓, 15,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 28,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   CLDN1↓, 2,   GLUT1↓, 2,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   MMP↓, 23,   TRPM7↓, 1,   TRPV1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   CD4+↑, 1,   CD44↓, 3,   CD47↓, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 28,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCR4↓, 4,   DR4↑, 1,   FOXP3↓, 1,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 5,   IFN-γ↓, 2,   IL1↓, 3,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 2,   IL4↓, 1,   IL6↓, 16,   IL8↓, 3,   Imm↑, 3,   Inflam↓, 8,   Inflam↑, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 3,   NF-kB↓, 35,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 5,   NLRP3↓, 2,   NLRP3↑, 2,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 3,   PGE1↓, 1,   PGE2↓, 9,   PSA↓, 1,   RAGE↓, 1,   Resistin↓, 1,   T-Cell↑, 1,   Th1 response↑, 2,   Th17↑, 1,   TLR4↓, 2,   TNF-α↓, 12,   TNF-α↑, 1,   TRADD↑, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   ERα/ESR1↓, 1,   Estro↝, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 11,   BioAv↑, 6,   BioAv↝, 5,   ChemoSen↑, 41,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↓, 2,   CYP1A2↓, 1,   DDS↑, 1,   Dose↑, 2,   Dose↝, 15,   Dose∅, 1,   eff↓, 4,   eff↑, 17,   eff↝, 1,   eff∅, 1,   Half-Life↓, 2,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P-gp/ABCB1↑, 1,   P450↓, 1,   RadioS↑, 11,   selectivity↑, 22,   Synergy?, 1,   Synergy↑, 31,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 3,   ALAT↓, 1,   AR↓, 4,   BMD↑, 1,   BP↓, 1,   BRCA1↑, 1,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 2,   EGFR↓, 8,   EGFR↑, 2,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   EZH2↓, 2,   FOXM1↓, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 16,   KRAS↓, 1,   LDH↝, 1,   NSE↓, 1,   PD-L1↓, 3,   PSA↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 22,   antiNeop↑, 1,   AntiTum↑, 5,   Appetite↑, 1,   BowelM↑, 1,   cachexia↓, 2,   cardioP↑, 8,   chemoP↑, 18,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 3,   fatigue↓, 1,   hepatoP↑, 8,   Mucositis↓, 1,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↑, 7,   Pain↓, 3,   PFS↑, 1,   QoL↑, 4,   radioP↑, 8,   RenoP↑, 5,   Risk↓, 4,   Sleep↑, 2,   toxicity↓, 4,   toxicity↝, 1,   TumVol↓, 9,   TumW↓, 2,   Weight↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 4,  
Total Targets: 555

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx?, 2,   antiOx↓, 2,   antiOx↑, 125,   ARE↑, 4,   Bil↓, 1,   Bil↑, 1,   Catalase↑, 273,   Copper↓, 1,   Fenton↓, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↓, 2,   GPx↑, 121,   GPx1↑, 5,   GPx3↑, 1,   GPx4↓, 1,   GPx4↑, 5,   GSH↓, 1,   GSH↑, 129,   GSR↓, 1,   GSR↑, 26,   GSTs↑, 37,   H2O2↓, 11,   HDL↓, 1,   HDL↑, 5,   HO-1↓, 3,   HO-1↑, 74,   HO-1⇅, 1,   Iron↓, 2,   i-Iron↓, 1,   Keap1↓, 4,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 86,   MDA↓, 107,   MDA↑, 2,   MPO↓, 7,   MPO↑, 1,   NADH↓, 1,   NOX↓, 3,   NOX4↓, 3,   NQO1↑, 16,   Nrf1↑, 2,   NRF2↓, 4,   NRF2↑, 107,   Prx↑, 4,   RNS↓, 5,   ROMO1↑, 1,   ROS?, 2,   ROS↓, 216,   ROS↑, 2,   ROS⇅, 2,   ROS∅, 1,   mt-ROS?, 1,   mt-ROS↓, 3,   SAM-e↑, 1,   SOD?, 2,   SOD↓, 2,   SOD↑, 222,   SOD1↑, 9,   SOD2↑, 8,   TAC↑, 18,   TBARS↓, 5,   TBARS↑, 1,   Thiols↑, 3,   TOS↓, 1,   Trx↓, 1,   Trx↑, 3,   Trx1↑, 3,   uricA↓, 3,   VitC↑, 4,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 8,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   EGF↓, 1,   ETC↑, 1,   HSP60/HSPD1↓, 1,   Insulin↑, 3,   MFN1↑, 1,   MFN2↑, 1,   mtDam↓, 7,   NGB↑, 1,   OCR↑, 1,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 3,   PGC-1α↝, 1,   SIRT3↑, 3,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 6,   ACC↓, 1,   ACC↑, 1,   mt-ACC⇅, 1,   ACSL4↓, 1,   ALAT↓, 33,   ALAT∅, 1,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 9,   ATP↑, 12,   ATP↝, 1,   Buty↑, 1,   cAMP↑, 1,   CRM↑, 1,   cytoP450↓, 1,   DGAT1↓, 1,   FAO↑, 1,   FASN↓, 2,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 6,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 3,   Glycolysis↝, 1,   GSK‐3β↓, 12,   GSK‐3β↑, 1,   H2S↑, 2,   HK2↓, 1,   HK2↑, 1,   HMG-CoA↓, 2,   IDH1↑, 1,   LDL↓, 14,   NAD↑, 2,   NAD↝, 1,   NADPH↓, 8,   NADPH↑, 7,   PDKs↑, 1,   PFK↓, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↑, 1,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 16,   SREBP1/SREBF1↓, 1,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 23,   ASC↓, 1,   ASK1↓, 1,   BAD↓, 1,   BAX↓, 20,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-2↑, 17,   Bcl-2↝, 1,   Bcl-xL↑, 1,   Casp↓, 1,   Casp1↓, 1,   Casp12↓, 1,   Casp3↓, 30,   Casp3↑, 1,   cl‑Casp3↓, 2,   Casp8↓, 2,   Casp9↓, 9,   Cyt‑c↓, 4,   Fas↓, 1,   Ferroptosis↓, 5,   GranB/GZMB↓, 1,   iNOS↓, 31,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 6,   p38↑, 1,   p‑p38↓, 1,   survivin↓, 1,   TUNEL↓, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   Akt↑, 14,   p‑Akt↓, 1,   p‑Akt↑, 3,   CREB↑, 2,   p‑CREB↑, 3,   ERK↓, 6,   ERK↑, 4,   p‑ERK↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   Hippo↑, 1,   IKKα↓, 1,   IKKα↑, 1,   IκB?, 1,   JAK2↓, 2,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 9,   JNK↑, 1,   p‑JNK↓, 4,   MAPK↓, 13,   MAPK↑, 2,   MAPK↝, 1,   p‑MAPK↓, 1,   mTOR↓, 4,   mTOR↑, 6,   p‑mTOR↓, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PFKFB2↓, 1,   PI3K↓, 4,   PI3K↑, 13,   p‑PI3K↓, 1,   PKCδ↑, 1,   PP2A↑, 1,   PTEN↓, 1,   PTEN↑, 2,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 4,   STAT3↑, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   ATF4↓, 2,   cJun↓, 1,   cMyc↓, 1,   FOXO1↝, 1,   FOXO3?, 1,   FOXO3↑, 3,   HDAC↓, 1,   miR-34a↓, 1,   other↓, 6,   other↑, 14,   other↝, 5,   RUNX2↑, 1,   SOX2↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 7,   GRP78/BiP↓, 6,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 4,   HSPs↑, 1,   PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 2,   MitoP↑, 2,   p62↓, 1,   p62↑, 3,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 13,   P53↓, 2,   PARP↓, 1,   PARP1↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   BMPs↑, 1,   Diff↝, 1,   IGF-1↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 1,   NOTCH1↑, 1,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 9,   AP-1↓, 3,   AP-1↑, 1,   BACH1↓, 1,   Ca+2↓, 9,   Ca+2↑, 1,   Ca+2↝, 1,   i-Ca+2↓, 1,   Cartilage↑, 2,   COL1↓, 2,   COL1↑, 2,   E-cadherin↑, 1,   EMT↓, 1,   Fibrosis↓, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 7,   MMPs↓, 5,   MUC1↑, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   serineP↓, 1,   TGF-β↓, 5,   TGF-β↑, 3,   TGF-β1↓, 2,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TXNIP↓, 2,   TXNIP↑, 1,   Vim↓, 1,   α-SMA↓, 5,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 1,   eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   LOX1↓, 2,   NO↓, 30,   NO↑, 6,   TXA2↓, 1,   VCAM-1↓, 5,   VEGF↓, 4,   VEGF↑, 5,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 2,   BBB↑, 18,   BBB↝, 1,   CLDN1↓, 1,   GastroP↑, 5,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 6,   MMP↓, 2,   MMP↑, 23,   OCLN↓, 1,   TJ↑, 2,   TRPA1↑, 1,   TRPC1↓, 1,   TRPM7↓, 3,   TRPM7⇅, 1,   TRPV3↑, 1,   ZO-1↓, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 57,   COX2/PTGS2↑, 2,   CXCc↓, 1,   FOXP3↑, 1,   HMGB1↓, 4,   ICAM-1↓, 6,   IFN-γ↓, 5,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 12,   IL10↑, 14,   IL12↓, 4,   IL12↑, 1,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 69,   IL1β↑, 1,   IL2↓, 4,   IL2↑, 1,   IL22↓, 1,   IL23↓, 1,   IL4↓, 8,   IL4↑, 4,   IL5↓, 2,   IL6↓, 65,   IL6↑, 5,   IL8↓, 7,   IL8↑, 1,   Imm↑, 9,   INF-γ↓, 2,   Inflam↓, 143,   Inflam↑, 1,   IP-10/CXCL-10↓, 2,   IRF3↓, 1,   LPS↓, 2,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MyD88↓, 2,   NeuroI↓, 5,   NF-kB↓, 76,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 16,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 19,   PGE2↑, 3,   RAGE↓, 5,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 19,   TNF-α↓, 94,   TNF-α↑, 2,   Treg lymp↝, 1,   TRIF↓, 2,   VitD↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 6,   Ach↑, 6,   AChE↓, 40,   AChE↑, 1,   ADAM10↑, 2,   BChE↓, 8,   BDNF↑, 26,   BDNF∅, 1,   ChAT↑, 5,   EndoR↑, 1,   GABA↓, 2,   GABA↑, 3,   MAOA↓, 5,   MAOB↓, 1,   monoA↓, 1,   monoA↑, 1,   NGF↑, 5,   PSD95↑, 1,   RELN↑, 1,   SNAP25↑, 1,   TPH1↓, 1,   TrkB↑, 4,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 6,   APP↓, 6,   Aβ↓, 41,   Aβ42↓, 3,   BACE/β-secretase↓, 9,   PSEN1/PS1↓, 1,   tau↓, 8,   p‑tau↓, 9,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   cortisol↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   GLP-1R↑, 1,   GR↑, 4,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 1,   PPARγ↑, 5,   testos↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 21,   BioAv↑, 48,   BioAv⇅, 1,   BioAv↝, 22,   BioEnh↑, 3,   ChemoSen↑, 1,   CompStab↑, 3,   CYP2D6↓, 1,   CYP2E1↓, 2,   CYP3A2↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose↝, 30,   eff↑, 23,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 6,   Half-Life↓, 1,   Half-Life↑, 2,   Half-Life↝, 9,   P-gp/ABCB1↓, 2,   P450↓, 2,   P450↑, 2,   selectivity↑, 1,   Synergy↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 33,   ALAT∅, 1,   ALP↓, 13,   AST↓, 35,   AST∅, 1,   BG↓, 4,   Bil↓, 1,   Bil↑, 1,   BloodF↑, 1,   BMD↑, 3,   BP↓, 10,   BP∅, 1,   BUN?, 1,   BUN↓, 4,   Calcium↑, 1,   CEA↓, 1,   creat↓, 10,   CRP↓, 7,   hs-CRP↓, 1,   IL6↓, 65,   IL6↑, 5,   LDH↓, 13,   LDH↑, 2,   Mag↑, 1,   NOS2↓, 2,   RAGE↓, 5,   SpO2↑, 1,   TG/TAG↓, 2,   Urea↓, 5,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll?, 1,   antiAll↑, 18,   AntiArt↑, 6,   AntiCan↑, 17,   antiCG↑, 1,   AntiDiabetic↑, 24,   antiM↑, 1,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 3,   antiPy↑, 1,   AntiTum↑, 1,   ANXi↓, 1,   cardioP?, 1,   cardioP↑, 53,   CardioT↓, 1,   chemoP↑, 11,   chemoPv↑, 3,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 51,   diuretic↑, 1,   hepatoP↑, 58,   Learn↑, 5,   memory↑, 49,   Mood↑, 1,   motorD↓, 1,   motorD↑, 8,   Mucositis↓, 2,   neuroP↑, 108,   NP/CIPN↓, 1,   Obesity↓, 10,   OS↑, 2,   Pain↓, 6,   QoL↑, 2,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 24,   Risk↓, 3,   Sleep↑, 3,   Strength↑, 3,   Stroke↓, 8,   toxicity?, 2,   toxicity↓, 20,   toxicity↑, 2,   toxicity↝, 7,   toxicity∅, 4,   Weight↓, 2,   Weight↑, 1,   Wound Healing↓, 1,   Wound Healing↑, 8,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 13,   AntiFungal↑, 4,   AntiP↑, 1,   AntiViral↑, 6,   Bacteria↓, 14,   Diar↓, 2,   GutMicro↑, 27,   Inf↓, 1,   Sepsis↓, 8,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Ingr↝, 4,   Phen↑, 1,   QC↑, 1,  
Total Targets: 583

Scientific Paper Hit Count for: Catalase, Catalase
15 Thymoquinone
12 Curcumin
11 Hydrogen Gas
8 Carvacrol
8 Magnetic Fields
8 Quercetin
7 Ferulic acid
7 Luteolin
6 Silver-NanoParticles
6 Resveratrol
6 Melatonin
6 Lycopene
6 Moringa oleifera
6 Silymarin (Milk Thistle) silibinin
5 Chrysin
5 Propolis -bee glue
5 Selenium NanoParticles
5 EGCG (Epigallocatechin Gallate)
5 Rosmarinic acid
4 Alpha-Lipoic-Acid
4 Betulinic acid
4 Boron
4 Chlorogenic acid
4 Chemotherapy
4 Eugenol
4 Hyperoside
4 Urolithin
3 Radiotherapy/Radiation
3 Crocetin
3 D-limonene
3 Fisetin
3 Gallic acid
3 Isoliquiritigenin
3 L-Theanine
3 Licorice
3 Pterostilbene
3 Sulforaphane (mainly Broccoli)
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Baicalein
2 Berberine
2 Boswellia (frankincense)
2 α-Bisabolol / Chamomile oil
2 buckwheat sprouts
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Cichoric acid / Chicoric acid
2 Date Fruit Extract
2 Sesame seeds and Oil
2 HydroxyCitric Acid
2 Hibiscus sabdariffa
2 Honokiol
2 Kaempferol
2 Magnolol
2 Matrine
2 Magnetic Field Rotating
2 Morin
2 Methylsulfonylmethane
2 Piperine
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 Annona atemoya Seed Extract
1 Allicin (mainly Garlic)
1 Artemisinin
1 Aloe anthraquinones
1 Beta-Caryophyllene
1 Benzyl isothiocyanate
1 Phenethyl isothiocyanate
1 Allyl isothiocyanate
1 Bacopa monnieri
1 Selenium
1 Beetroot
1 Caffeic acid
1 Capsaicin
1 Celastrol
1 Citicoline, CDP-Choline
1 Carvone
1 doxorubicin
1 Ginkgo biloba-EGb 761
1 Emodin
1 Exercise
1 Formononetin
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Geraniol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Germacranolide sesquiterpene lactone
1 Orlistat
1 Inositol
1 Butein
1 Scopoletin
1 isoorientin
1 isoquercitrin
1 Linalool
1 Mung Bean Sprouts
1 Methyl Jasmonate
1 Magnesium
1 Lemon Balm/Melissa officinalis
1 Cisplatin
1 Nimbolide
1 Oleuropein
1 HydroxyTyrosol
1 Marjoram (Origanum majorana)
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Selenite (Sodium)
1 Taurine
1 5-fluorouracil
1 Turmerones
1 Ursolic acid
1 Walnut
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:46  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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