TSC2 Cancer Research Results

TSC2, tuberous sclerosis complex (TSC): Click to Expand ⟱
Source:
Type:
TSC2 is a tumor suppressor gene as well as a disease-causing gene for autosomal dominant disorder tuberous sclerosis complex (TSC).

TSC1 (hamartin) and TSC2 (tuberin) form a complex that plays a critical role in regulating the mTOR (mechanistic target of rapamycin) pathway.
• The TSC1/TSC2 complex acts as a negative regulator of mTOR signaling; when active, it helps suppress cell growth and proliferation.

TSC1 and TSC2 serve as tumor suppressors.
TSC1 and TSC2 are not overexpressed in cancer; they are typically involved in loss-of-function scenarios that lead to tumorigenesis.
Scientific Papers found: Click to Expand⟱
250- AL,    Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells
- in-vitro, Liver, HepG2
P53↓, PI3K↓, mTOR↓, Bcl-2↓, AMPK↑, TSC2↑, Beclin-1/ATG6↑, TumAuto↑, tumCV↓, ATG7↑, MMP↓,
1357- Ash,    Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, GL26
TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,
750- Bor,    Calcium fructoborate regulate colon cancer (Caco-2) cytotoxicity through modulation of apoptosis
- in-vitro, CRC, Caco-2
Bcl-2↓, BAX↑, Akt↓, p70S6↓, PTEN↑, TSC2↑,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
1237- PTS,    Pterostilbene induces cell apoptosis and inhibits lipogenesis in SKOV3 ovarian cancer cells by activation of AMPK-induced inhibition of Akt/mTOR signaling cascade
- in-vitro, Ovarian, SKOV3
TumCMig↓, TumCI↓, MDA↑, ROS↑, BAX↑, Casp3↑, Bcl-2↓, SREBP1/SREBF1↓, FASN↓, AMPK↓, p‑AMPK↑, p‑P53↑, p‑TSC2↑, p‑Akt↓, p‑mTOR↓, p‑S6K↓, p‑4E-BP1↓,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓, TumCCA↑, chemoPv↑,
7921- VT,    Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches
- in-vitro, Colon, Caco-2
Dose↝, tumCV↓, SOD↓, Catalase↓, MDA↑, P53↑, BAX↓, TSC2↑, SESN2↑, PUMA↑, AMPK↑, PI3K↑, Akt↑, mTOR↓,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   RUBCN↓, 1,   THEM4/CTMP↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   ULK1/ATG1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↑, 2,   ROS↓, 1,   ROS↑, 4,   SOD↓, 1,   TrxR1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   BCR↓, 1,   CDC16↓, 1,   CDC2↓, 1,   CDC25↓, 1,   EGF↓, 1,   MMP↓, 2,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↓, 1,   AMPK↑, 2,   p‑AMPK↑, 1,   ATG7↑, 2,   cMyc↓, 1,   FASN↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   PDK1 / PDPK1↓, 1,   p‑S6K↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Akt↑, 1,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 2,   mt-Apoptosis↑, 1,   BAD↑, 1,   BAX↓, 1,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   CBP↑, 1,   Cyt‑c↑, 2,   DR5↑, 1,   Fas↑, 1,   MDM2↓, 1,   PUMA↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   CDC7↓, 1,   HER2/EBBR2↓, 1,   p70S6↓, 2,   Sp1/3/4↓, 1,   TSC2↑, 7,   p‑TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↓, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSF1↓, 1,   HSP70/HSPA5↑, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↑, 1,   SESN2↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   CUL4B↑, 1,   DNAdam↑, 1,   P53↓, 1,   P53↑, 2,   p‑P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 2,   cycF↓, 1,   E2Fs↓, 1,   P21↑, 2,   RB1↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   cDC2↓, 1,   cFos↓, 1,   p‑cMET↑, 1,   EMT↓, 1,   EP300↑, 1,   ERK↓, 2,   mTOR↓, 5,   p‑mTOR↓, 1,   mTORC1↓, 1,   mTORC2↓, 1,   NF2↑, 1,   P70S6K↓, 1,   p85S6K↓, 1,   PI3K↓, 3,   PI3K↑, 1,   PTEN↑, 2,   TCF-4↓, 1,   TumCG↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 1,   CDK4/6↓, 1,   MMP-10↓, 1,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 1,   MSH2↑, 1,   PKCδ↓, 1,   TGF-β↓, 1,   TSC1↑, 2,   TumCA↓, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 2,   uPA↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↑, 2,   EGFR↓, 2,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Imm↑, 1,   NF-kB↓, 1,   PD-L1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioEnh↑, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↓, 1,   eff↑, 2,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BRCA1↑, 1,   EGFR↓, 2,   HER2/EBBR2↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,   PRAS40↑, 1,   TGFβR1↑, 1,  
Total Targets: 166

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TSC2, tuberous sclerosis complex (TSC)
1 Allicin (mainly Garlic)
1 Ashwagandha(Withaferin A)
1 Boron
1 Fisetin
1 Licochalcone A
1 Pterostilbene
1 Quercetin
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:497  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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