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| Type: |
| Once the cancer has begun, NO seems to play a protumoral role rather than antitumoral one as the concentration required to cause tumor cell cytotoxicity cannot be achieved by cancer cells. The mechanistic roles of nitric oxide (NO) during cancer progression have been important considerations since its discovery as an endogenously generated free radical. Nonetheless, the impacts of this signaling molecule can be seemingly contradictory, being both pro-and antitumorigenic, which complicates the development of cancer treatments based on the modulation of NO fluxes in tumors. At a fundamental level, low levels of NO drive oncogenic pathways, immunosuppression, metastasis, and angiogenesis, while higher levels lead to apoptosis and reduced hypoxia and also sensitize tumors to conventional therapies. However, clinical outcome depends on the type and stage of the tumor as well as the tumor microenvironment. Nitric oxide is generated by three main nitric oxide synthase isoforms: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS). – In many cancers, especially under inflammatory conditions, iNOS expression is upregulated. In contrast, eNOS levels may also be altered in cancers such as breast or prostate cancer. • Expression Patterns in Tumors: – Elevated iNOS expression is commonly observed in various tumor types (e.g., colon, breast, lung, and melanoma) and is often associated with an inflammatory microenvironment. – Changes in eNOS and nNOS expression have also been reported and may contribute to angiogenesis and tumor blood flow regulation. |
| 4382- | AgNPs, | Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism |
| - | in-vitro, | Nor, | RAW264.7 |
| 9178- | BITC, | Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats |
| - | in-vivo, | Nor, | NA |
| 2776- | Bos, | Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities |
| - | Review, | Var, | NA |
| 6050- | CUR, | SeNPs, | Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer's disease |
| - | in-vivo, | AD, | NA |
| 2688- | CUR, | Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 6732- | Dipy, | Dipyridamole enhances ischaemia-induced arteriogenesis through an endocrine nitrite/nitric oxide-dependent pathway |
| - | in-vivo, | Nor, | NA |
| 6733- | Dipy, | Dipyridamole reverses peripheral ischemia and induces angiogenesis in the Db/Db diabetic mouse hind-limb model by decreasing oxidative stress |
| - | in-vivo, | Diabetic, | NA |
| 6735- | Dipy, | Dipyridamole Reverses Peripheral Ischemia and Induces Angiogenesis in the Db/Db Diabetic Mouse Hind Limb Model by Decreasing Oxidative Stress |
| - | in-vivo, | Nor, | NA |
| 6829- | EMD, | Molecular Mechanisms of Action of Emodin: As an Anti-Cardiovascular Disease Drug |
| - | Review, | Nor, | NA |
| 2861- | FIS, | The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress |
| - | Review, | Nor, | NA | - | Review, | Stroke, | NA | - | Review, | Park, | NA |
| 7338- | Gra, | Pharmacological Activities of Soursop (Annona muricata Lin.) |
| - | Review, | Var, | NA |
| 4343- | H2, | Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis formation |
| - | vitro+vivo, | Nor, | NA |
| 2238- | MF, | Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects |
| - | Review, | Var, | NA |
| 4101- | MF, | Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation |
| - | Human, | Stroke, | NA |
| 4105- | MF, | Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses: a possible immuno-modulatory therapeutic effect in neurodegenerative diseases |
| - | Review, | AD, | NA |
| 4111- | MF, | Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell |
| - | Review, | Arthritis, | NA |
| 229- | MFrot, | MF, | Molecular mechanism of effect of rotating constant magnetic field on organisms |
| - | in-vivo, | Nor, | NA |
| 1937- | TQ, | Migration and Proliferation Effects of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) and Thymoquinone (TQ) on In Vitro Wound Healing Models |
| - | in-vitro, | Wounds, | 3T3 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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