HO-1 Cancer Research Results

HO-1, HMOX1: Click to Expand ⟱
Source:
Type:
(Also known as Hsp32 and HMOX1)
HO-1 is the common abbreviation for the protein (heme oxygenase‑1) produced by the HMOX1 gene.
HO-1 is an enzyme that plays a crucial role in various cellular processes, including the breakdown of heme, a toxic molecule. Research has shown that HO-1 is involved in the development and progression of cancer.
-widely regarded as having antioxidant and cytoprotective effects
-The overall activity of HO‑1 helps to reduce the pro‐oxidant load (by degrading free heme, a pro‑oxidant) and to generate molecules (like bilirubin) that can protect cells from oxidative damage

Studies have found that HO-1 is overexpressed in various types of cancer, including lung, breast, colon, and prostate cancer. The overexpression of HO-1 in cancer cells can contribute to their survival and proliferation by:
  Reducing oxidative stress and inflammation
  Promoting angiogenesis (the formation of new blood vessels)
  Inhibiting apoptosis (programmed cell death)
  Enhancing cell migration and invasion
When HO-1 is at a normal level, it mainly exerts an antioxidant effect, and when it is excessively elevated, it causes an accumulation of iron ions.

A proper cellular level of HMOX1 plays an antioxidative function to protect cells from ROS toxicity. However, its overexpression has pro-oxidant effects to induce ferroptosis of cells, which is dependent on intracellular iron accumulation and increased ROS content upon excessive activation of HMOX1.

-Curcumin   Activates the Nrf2 pathway leading to HO‑1 induction; known for its anti‑inflammatory and antioxidant effects.
-Resveratrol  Induces HO‑1 via activation of SIRT1/Nrf2 signaling; exhibits antioxidant and cardioprotective properties.
-Quercetin   Activates Nrf2 and related antioxidant pathways; contributes to anti‑oxidative and anti‑inflammatory responses.
-EGCG     Promotes HO‑1 expression through activation of the Nrf2/ARE pathway; also exhibits anti‑inflammatory and anticancer properties.
-Sulforaphane One of the most potent natural HO‑1 inducers; triggers Nrf2 nuclear translocation and upregulates a battery of phase II detoxifying enzymes.
-Luteolin    Induces HO‑1 via Nrf2 activation; may also exert anti‑inflammatory and neuroprotective effects in various cell models.
-Apigenin   Has been reported to induce HO‑1 expression partly via the MAPK and Nrf2 pathways; also known for anti‑inflammatory and anticancer activities.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
4434- AgNPs,  SSE,    Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway
- vitro+vivo, Nor, NA
*ROS↓, *Inflam↓, *NLRP3↓, *NF-kB↓, *NRF2↑, *HO-1↑, *toxicity↓,
9228- AITC,  BITC,  PEITC,    Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts
- in-vitro, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑,
9236- AITC,    Allyl Isothiocyanate Protects Acetaminophen-Induced Liver Injury via NRF2 Activation by Decreasing Spontaneous Degradation in Hepatocyte
- in-vivo, LiverDam, NA
*NRF2↑, *hepatoP↑, *HO-1↑,
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
1235- ALA,  Cisplatin,    α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
- in-vitro, Nor, HEI-OC1 - ex-vivo, NA, NA
ROS↑, HO-1↓, *toxicity↓, chemoP↑, *ROS↓, *HO-1↑, *SOD1↑, *NRF2↑,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3441- ALA,    α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice
- in-vivo, AD, NA
*tau↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, *VEGF↑, *HO-1↑, *Glycolysis↑, *HK1↑, *PGC-1α↑, *Hif1a↑, *neuroP↑,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
4278- ART/DHA,    Artemisinin Ameliorates the Neurotoxic Effect of 3-Nitropropionic Acid: A Possible Involvement of the ERK/BDNF/Nrf2/HO-1 Signaling Pathway
- in-vivo, Var, NA
*IL6↓, *Casp3↓, *Casp9↓, *BDNF↑, *ERK↑, *NRF2↑, *HO-1↑, *neuroP↑, *antiOx↑, *Inflam↓,
3687- Ash,    Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives
- Review, AD, NA
*Aβ↓, *tau↓, *HSPs↝, *antiOx↑, *ROS↓, *Inflam↓, *neuroP↑, *cognitive↑, *NF-kB↓, *HO-1↑, *memory↑, *AChE↓, *BChE↓, *ChAT↑, *Ach↑,
3161- Ash,    Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
- in-vivo, Stroke, NA
*neuroP↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *NRF2↑, *HO-1↑,
3163- Ash,  Rad,    Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis
- in-vitro, Var, NA
*radioP↑, selectivity↑, *Casp3↓, *DNAdam↓, *ROS↓, *GSH↓, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *Prx↑, *ERK↑,
5425- ASTX,    Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE/β-secretase↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,
5501- Ba,    Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review
- Review, GC, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, BAX↑, TumAuto↑, ROS↑, NRF2↝, PI3K↓, Akt↓, NF-kB↓, TGF-β↓, SMAD4↓, GPx4↓, MMP↓, *HO-1↑, *GSTs↑, *antiOx↑, *AntiTum↑, *NRF2↑, ChemoSen↑, Akt↓, mTOR↓, FAK↓, Ki-67↓,
2624- Ba,    Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression
- in-vitro, Nor, RAW264.7
*HO-1↑, *ERK↑, *ROS↓, *eff↑, *MMP↑, *Cyt‑c∅,
2623- Ba,    Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of baicalein against oxidative stress-induced DNA damage and apoptosis in HEI193 Schwann cells
- in-vitro, Nor, HEI193
*DNAdam↓, *ROS↓, *Bax:Bcl2↓, *p‑NRF2↑, *HO-1↑, *neuroP↑, *MMP↑,
2627- Ba,  Cisplatin,    Baicalein, a Bioflavonoid, Prevents Cisplatin-Induced Acute Kidney Injury by Up-Regulating Antioxidant Defenses and Down-Regulating the MAPKs and NF-κB Pathways
- in-vivo, Var, NA
RenoP↑, *iNOS↑, *TNF-α↓, *IL6↓, *NF-kB↓, *MAPK↓, *ERK↓, *JNK↓, *antiOx↑, *NRF2↓, *HO-1↑, *Cyt‑c∅, *Casp3∅, *Casp9∅, *PARP∅,
5552- BBM,    Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosine monophosphate‐activated protein kinase/nuclear factor erythroid 2‐related factor pathway and changes in the mitochondrial state
- in-vivo, Stroke, NA
*eff↑, *ROS↓, *mtDam↓, *AMPK↑, *NRF2↑, *NADPH↑, *HO-1↑, *cardioP↑,
1380- BBR,  doxoR,    treatment with ROS scavenger N-acetylcysteine (NAC) and JNK inhibitor SP600125 could partially attenuate apoptosis and DNA damage triggered by DCZ0358.
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑,
3678- BBR,    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
- Review, AD, NA
*APP↓, *PPARγ↑, *NF-kB↓, *Aβ↓, *cognitive↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *BioAv↑, *BioAv↝, *BBB↑, *motorD↑, *NRF2↑, *HO-1↑, *ROS↓, *p‑Akt↑, *p‑ERK↑,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6517- BCP,    β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways
- in-vivo, Nor, NA
*cardioP↑, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *TLR4↓, *NF-kB↓, *Inflam↓, *Apoptosis↓,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
6507- BCP,    Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation
- Review, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *TLR4↓, *NF-kB↓, *NLRP3↓, *MAPK↓, *NRF2↑, *HO-1↑, *PI3K↑, *Akt↑, *cAMP↑, *PKA↑, *CREB↑,
2758- BetA,    Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *SOD↑, *GSH↑, *p‑p38↓, *p‑JNK↓, *p‑ERK↓, *NRF2↑, *HO-1↑, *MAPK↓, *heparanase↑, *antiOx↑,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
9178- BITC,    Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats
- in-vivo, Nor, NA
*GastroP↑, *GSH↑, *SOD↑, *NO↑, *PGE2↑, *MDA↓, *TNF-α↓, *MPO↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *HSP70/HSPA5↑, *NF-kB↓, *Casp3↓, *Inflam↓, *ROS↓,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
3524- Bor,    Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice
- in-vivo, Nor, NA
*Inflam↓, *SOD↑, *MDA↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *NRF2↑, *HO-1↑,
1425- Bos,    Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway
- in-vivo, Nor, NA
*ChemoSen↑, *NRF2↑, *HO-1↑, *ROS↓, *lipid-P↓, *DNAdam↓,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2/KDR/Flk1↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2/PTGS2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓, *AntiArt↑, *AntiDiabetic↑, *antiAll↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
7944- BuckWS,    Extracts from Tartary Buckwheat Sprouts Restricts Oxidative Injury Induced by Hydrogen Peroxide in HepG2 by Upregulating the Redox System
- in-vitro, Nor, HepG2
*ROS↓, *MMP↑, *TAC↑, *SOD↑, *Catalase↑, *GSTA1↑, *NRF2↑, *NQO1↑, *HO-1↑,
7516- CA,    Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against Aβ-Induced Neurodegeneration and Memory Impairment
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *memory↑, *Learn↑, *cognitive↑, *ROS↓, *lipid-P↓, *NRF2↑, *HO-1↑, *Aβ↓, *BACE/β-secretase↓,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
4264- CA,    HO-1_Pathway">Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2HO-1 Pathway
- in-vivo, AD, NA
*NRF2↑, *HO-1↑, *Trx1↑, *BDNF↑, *5HT↑, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓,
5864- CA,    Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
- vitro+vivo, Stroke, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NQO1↑, *NRF2↑, *ARE↑, *ROS↓, *BBB↑,
5871- CA,    Carnosic Acid Attenuates an Early Increase in ROS Levels during Adipocyte Differentiation by Suppressing Translation of Nox4 and Inducing Translation of Antioxidant Enzymes
- in-vitro, Nor, NA
*ROS↓, *NF-kB↓, *Nrf1↑, *HO-1↑, *GSTs↑,
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,
2394- CAP,    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
- in-vitro, Nor, GES-1
*mtDam↓, *NRF2↑, *HO-1↑, *Trx↑, *GSS↑, *NQO1↑, *Keap1↓, *ROS↓, *PKM2↓, *LDHA↓, *Inflam↓,
5766- CAPE,    A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model
- in-vivo, Nor, NA
*MDA↓, *NF-kB↓, *p65↓, *TNF-α↓, *cl‑Casp3↓, *GSR↑, *GSH↑, *NRF2↑, *HO-1↑, *Bax:Bcl2↓, *antiOx↑, *Inflam↓,
5757- CAPE,    Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application
- Review, Nor, NA
*NF-kB↓, NF-kB↓, P53↑, FOXO↑, Wnt↓, TumCI↓, *HO-1↑, MMP9↓, MMP2↓, COX1↓, COX2/PTGS2↓, 5LO↓,
7520- CAPE,    Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway
- in-vivo, AD, NA
*ROS↓, *NRF2↑, *HO-1↑, *Apoptosis↓, *Inflam↓, *Learn↑, *memory↑, *cognitive↑, *neuroP↑, *p‑GSK‐3β↓, GFAP↓,
5900- CAR,  TV,    Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *cardioP↑, *neuroP↑, *NADPH↓, *NRF2↑, *HO-1↑, *IL1β↓, *TNF-α↓,
6254- CBC/D,    Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
- Review, Var, NA
*neuroP↑, *Imm↑, *Inflam↓, CSCs↓, HH↓, Gli↓, AST↓, ALAT↓, MDA↓, hepatoP↑, *NRF2↑, *HO-1↑, NF-kB?, GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, MMP2↑, MMP9↓, BioAv↑,
6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,

Showing Research Papers: 1 to 50 of 241
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 241

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 2,   Fenton↑, 3,   GPx↑, 1,   GPx4↓, 2,   GSH↓, 5,   GSH↑, 4,   GSH/GSSG↓, 1,   GSR↑, 1,   GSSG↑, 1,   GSTs↑, 2,   H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 1,   MDA↓, 1,   MDA↑, 1,   NOX↓, 1,   NOX4↓, 1,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 7,   NRF2↝, 1,   ROS?, 1,   ROS↓, 10,   ROS↑, 34,   ROS⇅, 1,   SOD↑, 3,   SOD1↑, 1,   SOD2↓, 1,   ox-Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   compI↓, 1,   compII↓, 1,   compIV↓, 1,   ETC↓, 2,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 6,   PGC-1α↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 3,   ALAT↓, 1,   AMPK↑, 4,   ATP↓, 5,   ATP↑, 1,   glucose↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   HK2↓, 1,   lactateProd↓, 2,   LDHA↓, 1,   NADPH↓, 1,   SCD1↓, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↑, 23,   BAX↓, 2,   BAX↑, 9,   Bax:Bcl2↑, 3,   Bcl-2↓, 8,   Bcl-xL↓, 1,   BIM↑, 2,   Casp↑, 5,   Casp↝, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   cl‑Casp3⇅, 1,   cl‑Casp7↑, 1,   Casp8↑, 3,   Casp9↑, 6,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 9,   Diablo↑, 2,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   GSDMD↑, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 3,   Mcl-1↓, 1,   MDM2↓, 1,   p38↓, 1,   p38↑, 2,   pS2/TFF1↓, 1,   Pyro↑, 1,   survivin↓, 3,   TumCD↓, 1,   XIAP↓, 4,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 24,   p‑Akt↓, 7,   AMPKα↑, 1,   CIP2A↓, 1,   p‑cMET↑, 1,   p‑CREB↑, 1,   EGFR↓, 4,   ERK↓, 7,   ERK↑, 1,   HER2/EBBR2↓, 1,   Hippo↝, 1,   IGF-1R↓, 2,   JAK↓, 2,   JNK↑, 2,   MAPK↓, 4,   MAPK↑, 3,   MAPK↝, 1,   MKK4↓, 1,   mTOR↓, 13,   mTOR↝, 1,   p‑mTOR↓, 1,   p70S6↓, 1,   P70S6K↓, 2,   PI3K↓, 21,   PI3K↑, 1,   p‑PI3K↓, 3,   PI3K/Akt↓, 1,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 5,   Raf↓, 1,   RAS↓, 2,   RAS↑, 1,   Sp1/3/4↓, 1,   STAT↓, 2,   STAT3↓, 8,   STAT3↑, 1,   p‑STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 3,   cJun↓, 3,   cMyc↓, 5,   DNMTs↓, 2,   EZH2↓, 1,   FOXO↑, 2,   FOXO1↓, 1,   FOXO4↑, 1,   HATs↓, 1,   HDAC↓, 2,   HDAC1↓, 3,   HDAC2↓, 1,   miR-124-3p↓, 1,   miR-19b↓, 1,   miR-34a↑, 1,   other?, 1,   other↑, 2,   other⇅, 1,   tumCV?, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↑, 2,   ER Stress↑, 7,   GRP78/BiP↑, 2,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP72↓, 1,   HSP90↓, 2,   IRE1↑, 1,   NQO2↑, 1,   PERK↑, 2,   p‑PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 2,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 6,   P53↑, 11,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 7,   PCNA↓, 3,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK2↓, 6,   CDK2↑, 1,   CDK4↓, 8,   CDK6↓, 2,   CDK6↑, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 11,   cycE/CCNE↓, 3,   Ki-67↓, 3,   P21↑, 5,   p27/CDKN1B↑, 2,   Securin↓, 1,   TumCCA↑, 23,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMPs↑, 2,   CD133↓, 1,   CD133↑, 1,   cFos↓, 2,   CSCs?, 1,   CSCs↓, 4,   Diff↑, 1,   Gli↓, 1,   HH↓, 2,   Ki-67↓, 3,   mTORC1↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH1↓, 1,   Shh↓, 1,   STAT1↓, 1,   TumCG↓, 9,   TumCG↑, 1,   TumCP↓, 19,   Wnt↓, 9,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   Cofilin↓, 1,   E-cadherin↑, 8,   EMT↓, 8,   EMT↝, 1,   FAK↓, 1,   FAK↑, 1,   KRAS↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 6,   MMP2↑, 1,   MMP3↓, 2,   MMP7↓, 1,   MMP9↓, 9,   MMP9↑, 2,   MMPs↓, 7,   N-cadherin↓, 6,   ROCK1↓, 1,   Smad1↓, 1,   SMAD4↓, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 2,   TGF-β1↓, 1,   TIMP2↑, 1,   TumCI↓, 9,   TumCMig↓, 7,   TumMeta↓, 10,   Twist↓, 2,   uPA↓, 3,   Vim↓, 6,   Zeb1↓, 1,   β-catenin/ZEB1↓, 10,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   CD31/PECAM-1↓, 1,   HIF-1↓, 2,   Hif1a↓, 7,   NO↑, 1,   VEGF↓, 11,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   GLUT4↓, 1,   MMP↓, 9,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD47↓, 1,   CD8+↑, 2,   COX1↓, 2,   COX2/PTGS2↓, 9,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR4↓, 2,   DR4↑, 1,   Eos↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL12↓, 1,   IL1β↓, 1,   IL1β↑, 1,   IL2↓, 1,   IL6↓, 6,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 4,   Inflam↑, 1,   MCP1/CCL2↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 20,   NK cell↑, 2,   NLRP3↓, 1,   NLRP3↑, 3,   PGE2↓, 6,   PSA↓, 2,   TCF↓, 2,   TLR4↓, 1,   TNF-α↓, 4,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 2,   FGF21↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 7,   chemoR↓, 1,   ChemoSen↑, 25,   Dose↓, 1,   Dose↑, 1,   Dose↝, 8,   eff↓, 2,   eff↑, 15,   eff⇅, 1,   eff↝, 2,   GSTM1↑, 1,   Half-Life↝, 4,   MDR1↓, 3,   P-gp/ABCB1↓, 2,   P-gp/ABCB1↑, 1,   RadioS↑, 5,   selectivity↑, 12,   selectivity∅, 1,   Synergy↑, 18,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↓, 2,   AST↓, 1,   BP↓, 1,   EGFR↓, 4,   EZH2↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 6,   KRAS↓, 1,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 5,   AntiTum↑, 4,   Appetite↑, 1,   cardioP↑, 3,   chemoP↑, 12,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 2,   neuroP↑, 3,   NP/CIPN↓, 1,   OS↑, 1,   Pain↓, 1,   PFS↑, 1,   QoL↑, 3,   radioP↑, 7,   RenoP↑, 3,   Sleep↑, 1,   toxicity↓, 3,   toxicity↝, 3,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 369

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 108,   ARE↓, 1,   ARE↑, 8,   Bil↑, 2,   Catalase↑, 75,   DUOX1↓, 1,   Fenton↓, 3,   GCLC↑, 5,   GCLC↝, 1,   GCLM↑, 4,   GCLM↝, 1,   GPx↓, 1,   GPx↑, 50,   GPx1↑, 1,   GPx4↑, 5,   GSH↓, 1,   GSH↑, 84,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 8,   GSS↑, 1,   GSSG↓, 1,   GSTs↓, 2,   GSTs↑, 13,   H2O2↓, 5,   H2O2↑, 1,   HDL↓, 1,   HNE↓, 2,   HNE↑, 1,   HO-1↑, 242,   HO-1⇅, 1,   HO-2↓, 1,   hyperG↝, 1,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 10,   Keap1↝, 1,   lipid-P↓, 48,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 78,   MPO↓, 14,   MPO↑, 1,   NOX↓, 2,   NOX1↓, 1,   NOX2↓, 2,   NOX4↓, 7,   NQO1↑, 50,   NQO1↝, 2,   Nrf1↑, 3,   NRF2↓, 4,   NRF2↑, 208,   p‑NRF2↑, 1,   ONOO↓, 1,   Prx↑, 3,   RNS↓, 2,   ROS?, 1,   ROS↓, 181,   ROS↑, 3,   ROS⇅, 3,   ROS∅, 1,   mt-ROS↓, 2,   SOD↑, 112,   SOD1↑, 6,   SOD2↑, 4,   TAC↑, 11,   TBARS↓, 4,   Thiols↑, 1,   TOS↓, 1,   Trx↑, 3,   Trx1↑, 6,   TrxR↑, 2,   TrxR1↑, 1,   UCPs↑, 1,   uricA↓, 1,   VitC↑, 5,   VitE↓, 1,   VitE↑, 4,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↑, 1,   IronCh↑, 10,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 8,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 4,   PGC-1α↝, 1,   PINK1↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

3MST/MPST↑, 1,   5LO↓, 3,   ACC↓, 1,   ACSL4↓, 2,   ALAT↓, 15,   AMPK↑, 16,   p‑AMPK↑, 1,   ATP↑, 9,   Buty↑, 1,   cAMP↑, 1,   CBS↑, 1,   CRM↑, 2,   cytoP450↓, 1,   FABP4↓, 1,   FASN↓, 1,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 4,   GlucoseCon↑, 6,   GlutMet↑, 1,   Glycolysis↑, 3,   GSK‐3β↓, 16,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 4,   H2S↑, 1,   HK1↑, 1,   HK2↑, 1,   LDHA↓, 1,   LDL↓, 6,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 9,   NADPH↑, 11,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PKM2↓, 2,   PKM2↑, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 25,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 31,   ASC?, 1,   ASC↓, 1,   ASK1↓, 1,   BAX↓, 12,   BAX↑, 2,   Bax:Bcl2↓, 7,   Bcl-2↓, 1,   Bcl-2↑, 16,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 2,   Casp1↓, 4,   proCasp1↓, 1,   Casp12↓, 2,   Casp3↓, 21,   Casp3↑, 1,   Casp3∅, 1,   cl‑Casp3↓, 5,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 6,   Casp9↑, 1,   Casp9∅, 1,   Cyt‑c↓, 4,   Cyt‑c∅, 3,   Ferroptosis↓, 9,   GranB/GZMB↓, 1,   iNOS↓, 35,   iNOS↑, 2,   necrosis↓, 2,   p38↓, 5,   p‑p38↓, 3,   Pyro?, 1,   Pyro↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 19,   p‑Akt↓, 1,   p‑Akt↑, 4,   e-Akt↑, 1,   AMPKα↑, 2,   CREB↑, 4,   p‑CREB↑, 2,   ERK↓, 9,   ERK↑, 9,   p‑ERK↓, 2,   p‑ERK↑, 2,   e-ERK↑, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 1,   JAK2↓, 1,   JAK2↑, 1,   JNK↓, 8,   p‑JNK↓, 5,   p‑JNK↑, 1,   LPAR1/EDG2↑, 1,   MAPK?, 1,   MAPK↓, 22,   p‑MAPK?, 1,   p‑MAPK↓, 2,   mTOR↓, 5,   mTOR↑, 1,   p‑mTOR↓, 2,   PI3K↓, 2,   PI3K↑, 14,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↓, 2,   PKCδ↑, 1,   PP2A↑, 2,   PTEN↓, 1,   RIP1↓, 1,   STAT↓, 1,   STAT3↓, 6,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF2↑, 1,   ATF4↓, 3,   ATF4↑, 1,   cJun↓, 1,   p‑cJun↓, 2,   p‑cMyc↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO↑, 1,   FOXO3↑, 2,   HDAC↓, 2,   HDAC↑, 1,   miR-34a↓, 1,   other?, 1,   other↓, 2,   other↑, 6,   other↝, 5,   SOX2↑, 1,   tumCV↓, 1,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 8,   p‑eIF2α↓, 1,   ER Stress↓, 5,   GRP78/BiP↓, 5,   GRP78/BiP↑, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 6,   HSP70/HSPA5↝, 1,   HSPs↑, 1,   HSPs↝, 1,   PERK↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3II↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 10,   PARP↓, 1,   PARP∅, 1,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   Ki-67↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   cFos↓, 1,   Choline↑, 1,   Diff↝, 1,   FGF↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 1,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 5,   AP-1↓, 3,   mt-ATPase↑, 1,   Ca+2↓, 9,   Ca+2↑, 1,   i-Ca+2↓, 1,   Cartilage↑, 1,   COL1↓, 1,   Fibrosis↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP1↓, 1,   MMP2↓, 2,   MMP2↑, 2,   MMP3↓, 1,   MMP9↓, 8,   MMP9↑, 1,   MUC1↑, 1,   Na+↑, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   TGF-β↓, 4,   TGF-β↑, 2,   TGF-β1↓, 2,   TGF-β1↑, 1,   TIMP1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TXNIP↓, 3,   uPA↑, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 1,   E-sel↓, 3,   Endoglin↑, 1,   eNOS↑, 1,   p‑eNOS↑, 2,   Hif1a↓, 1,   Hif1a↑, 2,   LOX1↓, 1,   NO↓, 23,   NO↑, 1,   TXA2↓, 1,   VCAM-1↓, 9,   VEGF↓, 4,   VEGF↑, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 21,   BBB↝, 1,   GastroP↑, 1,   GLUT2↑, 1,   GLUT3↑, 4,   GLUT4↑, 6,   H+/K+-ATPase↓, 1,   IBI↑, 4,   memfluid↑, 1,   MMP↓, 2,   MMP↑, 14,   Na+↑, 1,   NHE3↑, 1,   OCLN↑, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPC1↓, 1,   TRPV1↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 2,   CD25+↑, 1,   CD4+↑, 2,   CD40↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 50,   COX2/PTGS2↑, 1,   CXCc↓, 1,   FOXP3↑, 2,   HMGB1↓, 5,   ICAM-1↓, 10,   IFN-γ↓, 8,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 7,   IL10↑, 12,   IL12↓, 3,   IL17↓, 6,   IL18↓, 2,   IL1β↓, 69,   IL2↓, 5,   IL22↓, 1,   IL23↓, 3,   IL33↓, 2,   IL4↓, 3,   IL4↑, 5,   IL6↓, 67,   IL6↑, 2,   IL8↓, 5,   Imm↑, 4,   Imm↝, 1,   Inflam?, 1,   Inflam↓, 133,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   LPS↓, 1,   M2 MC↑, 1,   MCP1/CCL2↓, 8,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   MyD88↓, 2,   NeuroI↓, 3,   NF-kB↓, 91,   NF-kB↑, 3,   NK cell↑, 1,   NLRP3↓, 29,   NLRP3↑, 1,   NOD1↓, 1,   p65↓, 5,   PGE2↓, 15,   PGE2↑, 1,   RAGE↓, 3,   RANTES↓, 1,   TLR1↓, 1,   TLR2↓, 2,   TLR3↓, 1,   TLR4↓, 16,   TLR4↑, 1,   TLR4∅, 1,   TNF-α↓, 91,   TNF-α↑, 1,   TRAF6↓, 1,   Treg lymp↝, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 5,   Ach↑, 4,   AChE↓, 30,   AChE∅, 1,   BChE↓, 7,   BChE∅, 1,   BDNF↑, 25,   BrainVol↑, 1,   ChAT↑, 6,   ChE↓, 1,   GABA↑, 2,   GDNF↑, 1,   MAOA↓, 4,   MAOB↓, 2,   NGF↑, 3,   PSD95↑, 4,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 4,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 4,   Aβ↓, 37,   BACE/β-secretase↓, 14,   tau↓, 11,   p‑tau↓, 9,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   END↑, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GLP-1R↑, 1,   GR↑, 2,   NR1H4↑, 1,   PPARα↑, 4,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 13,   RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 24,   BioAv↑, 33,   BioAv↝, 19,   ChemoSen↑, 3,   CompStab↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 20,   eff↓, 2,   eff↑, 19,   eff↝, 1,   GSTA1↓, 1,   GSTA1↑, 4,   Half-Life↓, 5,   Half-Life↑, 2,   Half-Life↝, 6,   MRP↓, 1,   P-gp/ABCB1↓, 1,   P450↑, 2,   selectivity↑, 2,   Synergy↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 15,   ALB↑, 1,   ALP↓, 3,   AST↓, 15,   BG↓, 1,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 2,   BP↓, 6,   BUN?, 1,   BUN↓, 4,   creat↓, 8,   CRP↓, 5,   Ferritin↑, 1,   IL6↓, 67,   IL6↑, 2,   IRes↝, 1,   LDH↓, 6,   LDH↑, 3,   NOS2↓, 4,   RAGE↓, 3,   SpO2↑, 1,   TMAO↓, 1,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 9,   antiAll↑, 10,   AntiArt↑, 3,   AntiCan↑, 11,   antiCG↑, 1,   AntiDiabetic↑, 11,   antiPs↑, 1,   AntiTum↑, 5,   ANXi↓, 1,   cardioP?, 2,   cardioP↑, 41,   CardioT↓, 2,   chemoP↑, 11,   chemoPv↑, 1,   cognitive↑, 44,   diuretic↑, 2,   fatigue↓, 1,   GFR↑, 1,   hepatoP↓, 1,   hepatoP↑, 40,   Learn↑, 5,   memory↑, 46,   Mood↑, 1,   motorD↓, 1,   motorD↑, 5,   neuroP↑, 105,   NP/CIPN↓, 2,   Obesity↓, 8,   OS↑, 5,   Pain↓, 3,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 24,   Risk↓, 1,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 3,   Stress↓, 1,   Stroke↓, 10,   toxicity↓, 9,   toxicity↝, 2,   toxicity∅, 3,   Weight↓, 1,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 4,   AntiViral↑, 6,   Bacteria↓, 8,   Diar↓, 1,   GutMicro↑, 20,   Sepsis↓, 7,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 577

Scientific Paper Hit Count for: HO-1, HMOX1
12 Thymoquinone
11 Curcumin
11 Resveratrol
9 Sulforaphane (mainly Broccoli)
8 Hydrogen Gas
8 Quercetin
7 Ferulic acid
7 isoorientin
6 Luteolin
6 Lycopene
6 Silymarin (Milk Thistle) silibinin
5 Alpha-Lipoic-Acid
5 Cisplatin
5 Isoliquiritigenin
5 Morin
5 Propolis -bee glue
5 Shikonin
4 Baicalein
4 Beta-Caryophyllene
4 Carnosic acid
4 Honokiol
4 Hyperoside
4 Pterostilbene
3 Allyl isothiocyanate
3 Benzyl isothiocyanate
3 Ashwagandha(Withaferin A)
3 Boswellia (frankincense)
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Chlorogenic acid
3 Chrysin
3 Crocetin
3 Chemotherapy
3 EGCG (Epigallocatechin Gallate)
3 Emodin
3 Fisetin
3 isoquercitrin
3 Isovitexin
3 Rosmarinic acid
3 Vitexin
2 Selenite (Sodium)
2 Phenethyl isothiocyanate
2 Radiotherapy/Radiation
2 Berberine
2 doxorubicin
2 Betulinic acid
2 Boron
2 Capsaicin
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Ginger/6-Shogaol/Gingerol
2 SDG/lignans
2 Linalool
2 Melatonin
2 5-fluorouracil
1 1,8-Cineole
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Astaxanthin
1 Berbamine
1 xanthohumol
1 buckwheat sprouts
1 Caffeic acid
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Centella asiatica / Gotu kola → asiaticoside
1 Cucurbitacin
1 diet Methionine-Restricted Diet
1 Diindolylmethane
1 Indole-3-carbinol
1 Dandelion Root
1 Fucoidan
1 Gallic acid
1 Geraniol
1 Ginseng
1 hydrogen sulfide
1 Isobavachalcone
1 Isorhamnetin
1 Kaempferol
1 lambertianic acid
1 Licochalcone A
1 Licorice
1 Matrine
1 Magnetic Fields
1 Lemon Balm/Melissa officinalis
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane, Hericium erinaceus
1 nicotinamide adenine dinucleotide
1 Nimbolide
1 Phenolic Acids
1 Hydroxycinnamic-acid
1 Piperine
1 Piperlongumine
1 Polyphenols
1 Sesame seeds and Oil
1 Taurine
1 Urolithin
1 Vanillic Acid
1 Mung Bean Sprouts
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:597  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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