p62 Cancer Research Results

p62, p62/sequestosome 1 (SQSTM1): Click to Expand ⟱
Source:
Type:
A protein that plays a crucial role in various cellular processes, including autophagy, cell signaling, and protein degradation.
p62 is a scaffold protein that interacts with various signaling molecules, including kinases, phosphatases, and ubiquitin ligases. It is also a substrate of autophagy, a process by which cells recycle damaged or dysfunctional organelles and proteins.
p62 is overexpressed in various types of cancer, including breast, lung, colon, and liver cancer.
Its overexpression has been associated with poor prognosis and reduced survival in some cancers.
Scientific Papers found: Click to Expand⟱
2287- AgNPs,    Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine
- in-vitro, Nor, HUVECs
*TumCP↓, *ROS↑, *eff↓, *MDA↑, *GSH↓, *MMP↓, *ATP↓, *LC3II↑, *p62↑, *Bcl-2↓, *BAX↑, *Casp3↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8246- LCA,    Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349
- in-vivo, Arthritis, NA
*AntiBio↑, *AntiTum↑, *Inflam↓, *AntiArt↑, *p62↑, *NRF2↑,
8242- LCA,    Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A
- in-vivo, LiverDam, NA
*ALAT↓, *AST↓, *Inflam↓, *ROS↓, *TLR4↓, *MAPK↓, *NF-kB↓, *TXNIP↓, *NLRP3↓, *NRF2↑, *p62↑, *hepatoP↑, *autophagy↑,
1709- Lyco,    Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
- in-vitro, Nor, JB6
*antiOx↑, *NRF2↑, *GSH/GSSG↓, *Catalase↝, *GR↝, *SOD↝, *GPx↝, *GSH↑, *Keap1↓, *p62↑,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *Synergy↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   ROS↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GSK‐3β↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 1,   Mcl-1↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   EGFR↓, 1,   ERK↓, 1,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

CTSB↓, 1,   CTSD↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↓, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   mitA↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   i-Ca+2↑, 1,   E-cadherin↓, 1,   EMT↓, 1,   LAMs↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Slug?, 1,   Snail?, 1,   TIMP2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   FOXP3↑, 1,   NF-kB↓, 1,   PD-1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,  

Functional Outcomes(tgid=23) ⓘ

NP/CIPN↓, 1,  
Total Targets: 47

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 3,   Catalase↝, 1,   GPx↑, 2,   GPx↝, 1,   GSH↓, 1,   GSH↑, 2,   GSH/GSSG↓, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 1,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↓, 1,   MDA↓, 2,   MDA↑, 1,   NRF2↑, 6,   ROS↓, 5,   ROS↑, 1,   mt-ROS?, 1,   SOD↑, 2,   SOD↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 1,   ATP↓, 1,   ATP↑, 2,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 1,   BAX↓, 1,   BAX↑, 2,   Bcl-2↓, 2,   Casp3↓, 2,   Casp3↑, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   MAPK↓, 2,   mTOR↓, 1,   PI3K↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

RUNX2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 2,   MitoP↑, 1,   p62↓, 1,   p62↑, 7,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

Cartilage↑, 1,   COL1↑, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MMP↓, 1,   MMP↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   COX2/PTGS2↑, 1,   IL18↓, 1,   IL1β↓, 2,   IL6↓, 3,   Inflam↓, 4,   pol-M2 MC↑, 1,   NF-kB↓, 4,   NLRP3↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   CYP2E1↓, 1,   eff↓, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   AST↓, 3,   CRP↓, 1,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   motorD↑, 1,   neuroP↑, 2,   Obesity↓, 2,   radioP↑, 1,   Risk↓, 1,   Strength↑, 1,   Stroke↓, 1,   toxicity↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,   GutMicro↑, 1,  
Total Targets: 112

Scientific Paper Hit Count for: p62, p62/sequestosome 1 (SQSTM1)
2 Licochalcone A
1 Silver-NanoParticles
1 Formononetin
1 Kaempferol
1 Lycopene
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:602  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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