EPR Cancer Research Results

EPR, enhanced permeability and retention (EPR) effect: Click to Expand ⟱
Source:
Type:
Passive accumulation (in cells) is based on the unique architecture of the tumor tissue, where neo-angiogenesis leads to an atypical endothelial layer and to fenestrated vasculature, which together with the impaired lymphatic drainage guides the penetration and accumulation of nano-sized materials within the cancerous tissues.
Exploited for drug design in the nanomedicine field.
Scientific Papers found: Click to Expand⟱
4418- AgNPs,    Nanocarriers for the topical treatment of psoriasis - pathophysiology, conventional treatments, nanotechnology, regulatory and toxicology
- Human, PSA, NA
*Inflam↓, *EPR↑,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *Synergy↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp/ABCB1↓, Synergy↑, other↝,
5657- BNL,    Enhancing effect and safety assessment of borneol on the oral absorption of sub-100 nm PLGA nanoparticles
- in-vivo, Nor, NA
*toxicity↓, *EPR↑, *other↑,
8902- MOR,    Enhanced oral bioavailability of morin administered in mixed micelle formulation with PluronicF127 and Tween80 in rats
- vitro+vivo, Nor, NA
*Dose↝, *BioAv↑, *EPR↑, *other↑, *P-gp/ABCB1↓, *other↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

SOD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Inflam↓, 2,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 1,   eff↑, 1,   P-gp/ABCB1↓, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 17

Scientific Paper Hit Count for: EPR, enhanced permeability and retention (EPR) effect
2 borneol
1 Silver-NanoParticles
1 Morin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:612  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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