SIRT1 Cancer Research Results

SIRT1, Sirtuin 1 protein: Click to Expand ⟱
Source:
Type:
SIRT1 (Sirtuin 1) is a protein that plays a crucial role in various cellular processes, including metabolism, stress resistance, and longevity. In the context of cancer, SIRT1 has been found to have both tumor-suppressing and tumor-promoting functions, depending on the type of cancer and the cellular context.
Expression Promotes: Breast, Prostate, Colorectal Cancer.
Expression Suppresses: Leukemia, Liver Cancers.
-aging process is associated with the inactivation of the silent information regulator T1 (SIRT1) protein.
Scientific Papers found: Click to Expand⟱
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
3433- ALA,    Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals
- in-vitro, Nor, NA
*ROS↓, *Apoptosis↓, *Hif1a↑, *FOXO1↑, *FOXO3↑, *ATM↑, *SIRT1↑, *SIRT3↑, *CD34↑,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
6506- BCP,    Multi-Target Protective Effects of β-Caryophyllene (BCP) at the Intersection of Neuroinflammation and Neurodegeneration
- vitro+vivo, Nor, HMC3
*neuroP↑, *NF-kB↓, *SIRT1↑, *PGC-1α↓, *BDNF↓, *TNF-α↓, *IL6↓, *IL10↑, *Inflam↓,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
5834- CAP,    Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
- Study, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *TRPV1↑, *AMPK↑, *SIRT1↑, *NADPH↓, *ROS↓, *MAPK↓, *eNOS↑, *Wnt/(β-catenin)↓, RenoP↑,
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,
9000- Citicoline,    The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives
- Review, AD, NA
*BioAv↑, *cognitive↑, *SIRT1↑, *eff↑, *neuroP↑,
5780- CRMs,  HCAs,  RES,  Sper,  ASA  Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential
- Review, Var, NA
*OS↑, *AntiAge↑, *cardioP↑, *neuroP↑, AntiCan↑, *TNF-α↓, *Weight↓, *BP↓, *Inflam↓, *Insulin↓, *ROS↓, *AMPK↑, *mTOR↓, *SIRT1↑, CRM↑,
5792- CRMs,  HCA,  CUR,  EGCG,  GAR  Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
- Review, Nor, NA
*CRM↓, *Dose?, *AntiAge↑, *Acetyl-CoA↓, *SIRT1↑, *AMPK↑, *mTORC1↓, *AntiAge↑, chemoP↑,
5798- CRMs,    Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders
- Review, Nor, NA - Review, AD, NA
*GutMicro↑, *neuroP↑, *eff↑, *Dose↝, *AMPK↑, *SIRT1↑, *mTOR↓, *NRF2↑, *p‑tau↓,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
3635- Cro,    A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
- Review, AD, NA
*memory↑, *cognitive↑, *BioAv↑, *ROS↓, *IL1↓, *TNF-α↓, *NF-kB↓, *neuroP↑, *lipid-P↓, *Thiols↑, *antiOx↑, *AChE↓, *MAOA↝, *SIRT1↑, *PGC-1α↑, *Ach↑,
3862- CUR,  RES,    The metalloproteinase ADAM10: A useful therapeutic target?
- Review, AD, NA
*SIRT1↑, *ADAM10↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2/PTGS2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE/β-secretase↓, *AChE↓, *LDL↓,
3222- EGCG,    Epigallocatechin gallate and mitochondria—A story of life and death
- Review, Nor, NA
*lipid-P↓, *SOD↑, *Catalase↑, GPx↑, *GR↑, *GSTs↑, *GSH↑, *SIRT1↑, *PGC1A↑, *other↑,
3246- EGCG,    Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway
- in-vitro, Nor, NA
*MDA↓, *SOD↑, *SIRT1↑, *FOXO1↑, *SREBP2↓,
5519- EP,    Nanosecond Pulsed Electric Fields (nsPEFs) for Precision Intracellular Oncotherapy: Recent Advances and Emerging Directions
- Review, Var, NA
MMP↓, Ca+2↑, Synergy↑, ER Stress↑, selectivity↑, CSCs↓, CD44↓, CD133↓, ROS↑, Imm↑, DNAdam↑, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp9↑, TumCD↑, Fas↑, UPR↑, Dose↝, Dose↝, Dose↓, Dose↑, HMGB1↓, eff↑, EPR↑, ChemoSen↑, ETC↝, *AntiAge↑, *Hif1a↑, *SIRT1↑,
5523- EP,    Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication
- vitro+vivo, Nor, HUVECs
*MMP↑, *Hif1a↑, *SIRT1↑, *ROS↓, *AntiAge↑, *Dose↝, *angioG↑,
3716- FA,    Ferulic Acid as a Protective Antioxidant of Human Intestinal Epithelial Cells
- in-vitro, IBD, NA - in-vivo, NA, NA
*antiOx↑, *Inflam↓, *ER Stress↓, *other↑, *angioG↑, *Hif1a↑, *VEGF↑, *NO↓, *SIRT1↑, *PERK↓, *ATF4↓, *CHOP/DDIT3↓, *GutMicro↑,
8585- FS,    Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
- Review, Nor, NA
*cardioP↑, *Obesity↓, *lipidLev↓, *BP↓, *Inflam↓, *CRP↓, *IL6↓, *ROS↓, *hepatoP↑, *Ingr↝, *GutMicro↑, *Dose↑, *Ingr↝, *Ingr?, *CompStab↝, *MDA↓, *hs-CRP↓, *TNF-α↓, *AntiDiabetic↑, *ALAT↓, *AST↓, *GGT/CD224↓, *TG/TAG↓, *LDL↓, *HDL∅, *TC↓, *glucose↓, *Insulin↓, *SIRT1↑, *Dose↝, *Dose?,
7012- Fuc,    Fucoidan: A promising natural therapeutic agent for protecting human kidney health
- Review, EC, NA
*RenoP↑, *Inflam↓, *antiOx↑, *ROS↓, *BloodF↑, *diuretic↑, *BioAv↓, *BioAv↑, *MAPK↓, *ERK↑, *NLRP3↓, *NRF2↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *lipid-P↓, *DNAdam↓, *Fibrosis↓, *JAK2↓, *STAT3↓, *uricA↓, *COL1↓, *α-SMA↓, *SIRT1↑, *HO-1↑, *GLP-1R↑, *HMGB1↓, *RAGE↓, *NF-kB↓, *TGF-β1↓, *PI3K↓, *Akt↓, *GutMicro↑, *SCFAs↑, *Buty↑, *IBI↑, *TJ↑, *Dose↝,
3766- H2,    The role of hydrogen in Alzheimer′s disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *AMPK↑, *SIRT1↑, *FOXO↑, *mtDam↓, *neuroP↑, *ROS↓, *p38↓, *cognitive↑, *BDNF↑, *memory↑, *lipid-P↓, *IL6↓, *TNF-α↓, *JNK↓, *NF-kB↓, *NLRP3↓,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3776- H2,    The role of hydrogen in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *NLRP3↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *ROS↓, *BDNF↑,
3774- H2,    The role of hydrogen in Alzheimer’s disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *memory↑, *Aβ↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *p‑p38↓, *JNK↓, *ROS↓, *cognitive↑, *ER(estro)↑, *BDNF↑,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7782- ISL,  BUT,  SCP,    Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1/ADAM10 signaling pathway
- in-vitro, AD, SH-SY5Y
*Inflam↓, *AntiBio↑, *antiOx↑, *Apoptosis↓, *ROS↓, *SIRT1↑, *FOXO3↑, *ADAM10↑, *Bcl-2↝, *Catalase↑, *SOD2↑, *neuroP↑, *GSR↑, *GPx↑, *GSH↑,
7878- isoO,  Cisplatin,    Isoorientin Attenuates Cisplatin-Induced Nephrotoxicity Through the Inhibition of Oxidative Stress and Apoptosis via Activating the SIRT1/SIRT6/Nrf-2 Pathway
- in-vivo, Nor, NA
*antiOx↑, *RenoP↑, *chemoP↑, *SIRT1↑, *SIRT6↑, *NRF2↑, *HO-1↑, *NQO1↑, *NOX4↓, *ROS↓, *MPO↓, *MDA↓, *SOD↑, *GSH↑,
8086- KAE,    Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety
- Review, Nor, NA
*hepatoP↑, *BioAv↝, *CYP2E1↓, *antiOx↑, *AST↓, *ALAT↓, *ROS↓, *lipid-P↓, *SIRT1↑, *GSH↑, *SOD↑, *p‑SMAD2↓, *p‑SMAD3↓, *COL1↓, *other↝,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
9067- L-THE,    l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways
- in-vivo, AD, NA
*AGEs↓, *Aβ42↓, *Ach↑, *AChE↓, *NF-kB↓, *SIRT1↑, *Inflam↓, *RAGE↓, *SOD2↑, *Catalase↑, *ROS↓, *PGC-1α↓, *BAX↓, *cl‑Casp3↓, *Bcl-2↑, *BDNF↑,
8157- lamb,    Pinus koraiensis leaf extract and lambertianic acid attenuate fatigue and improve endurance capacity via PI3K-mediated regulation of oxidative stress and mitochondrial biogenesis
- in-vivo, Nor, NA
*fatigue↓, *ROS↓, *NF-kB↓, *IL6↓, *SOD↑, *PI3K↑, *NRF2↑, *HO-1↑, *SIRT1↑, *PGC-1α↑, *Nrf1↑, *Strength↑,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
4338- LT,    Luteolin: a natural product with multiple mechanisms for atherosclerosis
- Review, Var, NA
*Inflam↓, *ROS↓, *PDGF↓, *lipid-P↓, *AMPK↑, *SIRT1↑, *AntiAg↑,
8707- MET,    Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
- Review, Var, NA - Review, AD, NA
*BioAv↝, *cardioP↑, *Obesity↓, *neuroP↑, *toxicity↝, *Dose↝, *GutMicro↑, *AMPK↑, *glucose↓, *NLRP3↑, *Inflam↓, *Stroke↓, *Cartilage↑, FOXP3↑, TumAuto↑, mTOR↓, PD-L1↓, RadioS↑, ChemoSen↑, ROS↓, OXPHOS↓, compI↓, Glycolysis↝, TumCP↓, *BioAv↝, *AntiAge↑, *SIRT1↑, *cognitive↑, *Risk↓, Ki-67↓, Synergy↝, PFS∅, OS∅,
6419- MLT,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
6418- MLT,  RES,    Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1-PGC-1α pathway activation
- in-vivo, AD, NA
*neuroP↑, *DRP1/DNM1L↓, *FIS1↓, *ROS↓, *MMP↑, *SIRT1↑, *PGC-1α↑, *Synergy↑,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
2932- NAD,    Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment
- in-vitro, Nor, NA
*SIRT1↑, *HO-1↑, *neuroP↑, *Apoptosis↓, *Inflam↓, *ROS↓, *antiOx↑, *toxicity↓,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
2936- NAD,    The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
- Review, Nor, NA
*ROS↓, *DNAdam↓, *neuroP↑, *Inflam↓, *BioAv↑, *SIRT1↑, BioAv↝,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
2963- PL,    Piperlongumine activates Sirtuin1 and improves cognitive function in a murine model of Alzheimer’s disease
- in-vitro, AD, HEK293
*SIRT1↑, *cognitive↑, *Aβ↓, *Inflam↓, *neuroP↑, memory↑, Dose↓, NAD↑,
3350- QC,    Quercetin and the mitochondria: A mechanistic view
- Review, Var, NA
*antiOx↑, *Inflam↓, *NRF2↑, ROS⇅, *NRF2↑, *HO-1↑, *PPARα↑, *PGC-1α↑, *SIRT1↑, *ATP↑, ATP↓, ERK↓, cl‑PARP↑, Casp9↑, Casp8↑, BAX↑, MMP↓, Cyt‑c↑, Casp3↑, HSP27↓, HSP72↓, RAS↓, Raf↓,
3365- QC,    Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways
- in-vivo, Sepsis, NA
*ER Stress↓, *PDI↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *ATF6↓, *PERK↓, *IRE1↓, *MMP↑, *SOD↑, *ROS↓, *MDA↓, *SIRT1↑, *AMPK↑, *Sepsis↓,
3607- QC,    Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- Review, AD, NA - Review, Park, NA
*neuroP↑, *NRF2↑, *PONs↑, *antiOx↑, *Inflam↓, *SIRT1↑, *Synergy↑, *ROS↓, *cognitive↑, *Synergy↑, *lipid-P↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑,
3534- QC,  Lyco,    Synergistic protection of quercetin and lycopene against oxidative stress via SIRT1-Nox4-ROS axis in HUVEC cells
- in-vitro, Nor, HUVECs
*ROS↓, *NOX4↓, *Inflam↓, *NF-kB↓, *p65↓, *SIRT1↑, *cardioP↑, *IL6↓, *COX2/PTGS2↓,

Showing Research Papers: 1 to 50 of 84
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 84

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GPx↑, 1,   GSH↓, 1,   HO-1↑, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 2,   ROS↑, 5,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   ETC↝, 1,   mtDam↑, 1,   OXPHOS↓, 1,   OXPHOS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ATP↓, 3,   CRM↑, 1,   Glycolysis↓, 1,   Glycolysis↝, 1,   HK2↓, 1,   LDHA↓, 1,   NAD↑, 1,   SIRT1↓, 3,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis?, 1,   Apoptosis↑, 2,   BAX↑, 4,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp↑, 2,   Casp3↑, 5,   Casp7↑, 1,   Casp8↑, 3,   Casp9↑, 5,   Cyt‑c↑, 4,   Fas↑, 2,   MOMP↑, 1,   survivin↓, 1,   TumCD↑, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   p‑Akt↓, 1,   cSrc↓, 1,   EGFR↓, 2,   ERK↓, 2,   JAK2↓, 1,   MAPK↓, 2,   mTOR↓, 3,   PI3K↓, 4,   PTEN↑, 3,   Raf↓, 1,   RAS↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 3,   DNMT1↓, 1,   EZH2↓, 1,   HATs↑, 1,   HDAC↓, 2,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   miR-203↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP27↓, 1,   HSP72↓, 1,   NQO2↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 3,   cl‑PARP↑, 2,   Telomerase↓, 1,   TOP2↓, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↑, 1,   CDK4↓, 1,   CDK4↑, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 3,   P21↑, 3,   p27/CDKN1B↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 1,   CSCs↓, 2,   IGFBP3↑, 1,   Ki-67↓, 3,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   Shh↓, 1,   TumCG↓, 6,   TumCP↓, 3,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

CA↓, 1,   Ca+2↑, 2,   E-cadherin↓, 1,   E-cadherin↑, 4,   EMT↓, 4,   FAK↓, 1,   MALAT1↓, 1,   MMP13↓, 1,   MMP2↓, 2,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 4,   MMP9↑, 1,   MMPs↓, 1,   N-cadherin↓, 2,   PDGF↓, 1,   Slug↓, 1,   TGF-β↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 2,   Twist↓, 1,   uPA↓, 1,   Vim↓, 4,   Zeb1↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   HIF-1↓, 1,   Hif1a↓, 2,   VEGF↓, 7,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 1,   MMP↓, 5,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   COX2/PTGS2↓, 4,   COX2/PTGS2↑, 1,   CXCR4↓, 2,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 1,   NF-kB↓, 4,   PD-L1↓, 2,   PGE2↓, 1,   PSA↓, 1,   TCF↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER(estro)↓, 1,   FGF21↓, 1,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↝, 1,   ChemoSen↑, 3,   ChemoSen⇅, 1,   CompStab↝, 1,   Dose↓, 2,   Dose↑, 1,   Dose↝, 3,   eff↑, 3,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 1,   MDR1↓, 1,   P450↓, 1,   RadioS↑, 3,   selectivity↑, 3,   Synergy↑, 5,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 2,   EZH2↓, 1,   IL6↓, 2,   PD-L1↓, 2,   PSA↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 3,   hepatoP↑, 2,   memory↑, 1,   OS↑, 1,   OS∅, 1,   PFS∅, 1,   RenoP↑, 1,   toxicity↝, 1,   toxicity∅, 1,  
Total Targets: 196

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 35,   Catalase↑, 16,   GPx↑, 13,   GPx1↑, 1,   GSH↑, 18,   GSR↑, 3,   GSTs↑, 2,   H2O2↓, 2,   HDL∅, 1,   HO-1↑, 25,   HO-1⇅, 1,   Keap1↓, 1,   lipid-P↓, 17,   lipid-P↑, 1,   mt-lipid-P↓, 1,   MDA↓, 18,   MPO↓, 4,   NOX4↓, 2,   NQO1↑, 5,   Nrf1↑, 2,   NRF2↓, 1,   NRF2↑, 27,   ROS↓, 56,   ROS↑, 1,   mt-ROS↓, 1,   SOD↑, 23,   SOD1↑, 1,   SOD2↑, 3,   TAC↑, 2,   TBARS↓, 1,   Thiols↑, 1,   Trx↑, 1,   UCPs↑, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 2,   ETC↑, 1,   FIS1↓, 1,   Insulin↓, 2,   MFN1↑, 1,   MFN2↑, 1,   mtDam↓, 4,   OPA1↑, 1,   OXPHOS↑, 1,   PGC-1α↓, 3,   PGC-1α↑, 10,   SIRT3↑, 5,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

mt-ACC⇅, 1,   Acetyl-CoA↓, 2,   ALAT↓, 9,   AMPK↑, 25,   p‑AMPK↑, 1,   ATP↑, 3,   Buty↑, 1,   cAMP↑, 1,   CRM↓, 1,   CRM↑, 1,   FAO↑, 2,   G6PD↑, 1,   glucose↓, 2,   GlutMet↑, 1,   Glycolysis↝, 2,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   LDHA↑, 1,   LDL↓, 5,   lipidLev↓, 2,   lipoGen↓, 1,   NAD↑, 2,   NADH:NAD↑, 1,   NADPH↓, 4,   NADPH↑, 1,   PDK1 / PDPK1↓, 1,   PDKs↑, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 2,   PONs↑, 1,   SCFAs↑, 1,   SIRT1↑, 84,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 9,   ASC?, 1,   ASC↓, 1,   BAX↓, 5,   Bcl-2↑, 4,   Bcl-2↝, 1,   Casp1↓, 3,   Casp12↓, 1,   Casp3↓, 5,   cl‑Casp3↓, 2,   Casp8↓, 1,   Casp9↓, 3,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   iNOS↓, 7,   necrosis↓, 1,   p38↓, 1,   p‑p38↓, 1,   Pyro?, 1,   YAP/TEAD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   Akt↑, 1,   p‑Akt↑, 2,   CREB↑, 1,   p‑CREB↑, 2,   ERK↑, 1,   Hippo↑, 1,   JAK2↓, 1,   JNK↓, 2,   MAPK↓, 3,   mTOR↓, 5,   mTOR↑, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 2,   PKA↑, 1,   PP2A↑, 2,   PTEN↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 2,   cMyc↑, 1,   FOXO↑, 3,   FOXO1↑, 2,   FOXO3↑, 5,   miR-155↓, 1,   miR-34a↓, 1,   other↓, 1,   other↑, 4,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   ER Stress↓, 6,   GRP78/BiP↓, 4,   HSP27↑, 1,   HSP70/HSPA5↝, 1,   HSPs↓, 1,   IRE1↓, 1,   PDI↓, 1,   PERK↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   MitoP↑, 2,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DNAdam↓, 3,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↑, 1,   CLOCK↝, 1,   mTORC1↓, 1,   neuroG↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   BACH1↓, 1,   Ca+2↓, 2,   Ca+2↑, 1,   Cartilage↑, 1,   COL1↓, 3,   Fibrosis↓, 1,   MMP3↓, 1,   MMP9↓, 5,   MMP9↑, 1,   Na+↑, 1,   PDGF↓, 1,   p‑SMAD2↓, 2,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TXNIP↓, 2,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 5,   eNOS↑, 2,   Hif1a↑, 4,   NO↓, 10,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 6,   BBB↝, 1,   GastroP↑, 1,   GLUT4↑, 1,   IBI↑, 1,   MMP↑, 6,   Na+↑, 1,   TJ↑, 1,   TRPV1↑, 2,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 12,   HMGB1↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1↓, 2,   IL10↓, 1,   IL10↑, 2,   IL17↓, 1,   IL18↓, 2,   IL1β↓, 15,   IL2↓, 3,   IL23↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 20,   IL8↓, 2,   INF-γ↓, 1,   Inflam↓, 48,   MCP1/CCL2↓, 1,   NeuroI↓, 2,   NF-kB↓, 24,   NF-kB↑, 1,   NLRP3↓, 16,   NLRP3↑, 1,   p65↓, 2,   PGE2↓, 5,   RAGE↓, 2,   TLR4↓, 5,   TNF-α↓, 23,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 4,   AChE↓, 6,   ADAM10↑, 3,   BDNF↓, 1,   BDNF↑, 14,   ChAT↑, 2,   MAOA↝, 1,   NGF↑, 1,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 14,   Aβ42↓, 1,   BACE/β-secretase↓, 5,   PSEN1/PS1↓, 1,   tau↓, 1,   p‑tau↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↑, 1,   GLP-1R↑, 1,   GR↑, 1,   PPARα↑, 2,   PPARγ↑, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 12,   BioAv↑, 15,   BioAv↝, 7,   BioEnh↑, 2,   CompStab↝, 1,   CYP2E1↓, 3,   Dose?, 2,   Dose↑, 1,   Dose↝, 9,   eff↓, 1,   eff↑, 10,   Half-Life↓, 3,   Half-Life↝, 2,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 9,   ALP↓, 1,   AST↓, 8,   BG↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 4,   creat↓, 1,   CRP↓, 2,   hs-CRP↓, 1,   IL6↓, 20,   RAGE↓, 2,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 9,   antiAll↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 16,   chemoP↑, 1,   cognitive↑, 19,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↑, 13,   Learn↑, 1,   memory↑, 16,   motorD↑, 2,   neuroP↑, 36,   Obesity↓, 3,   OS↑, 4,   radioP↑, 1,   RenoP↓, 1,   RenoP↑, 6,   Risk↓, 2,   Sleep↑, 1,   Strength↑, 2,   Stroke↓, 2,   toxicity↓, 4,   toxicity↝, 1,   toxicity∅, 1,   Weight↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiP↑, 1,   GutMicro↑, 9,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↝, 2,  
Total Targets: 317

Scientific Paper Hit Count for: SIRT1, Sirtuin 1 protein
24 Resveratrol
6 Quercetin
5 Hydrogen Gas
4 Curcumin
4 EGCG (Epigallocatechin Gallate)
4 Urolithin
3 Calorie Restriction Mimetics
3 Melatonin
3 nicotinamide adenine dinucleotide
3 Thymoquinone
2 Alpha-Lipoic-Acid
2 Capsaicin
2 Crocetin
2 Electrical Pulses
2 Kaempferol
2 Luteolin
2 Silymarin (Milk Thistle) silibinin
1 Silver-NanoParticles
1 Beta-Caryophyllene
1 Carnosic acid
1 Citicoline, CDP-Choline
1 Hydroxycinnamic-acid
1 Spermidine
1 Aspirin
1 HydroxyCitric Acid
1 Garcinol
1 Ferulic acid
1 Flaxseed/Linseed
1 Fucoidan
1 Hyperoside
1 Isoliquiritigenin
1 Butein
1 Scopoletin
1 isoorientin
1 Cisplatin
1 L-Theanine
1 lambertianic acid
1 Licochalcone A
1 Metformin
1 Piperine
1 Piperlongumine
1 Lycopene
1 Radiotherapy/Radiation
1 Sesame seeds and Oil
1 Shikonin
1 Salvia miltiorrhiza
1 Vitamin B3,Niacin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:634  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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