SOCS-3 Cancer Research Results

SOCS-3, Suppressor of Cytokine Signaling 3: Click to Expand ⟱
Source:
Type:
SOCS-3) is a protein that plays a crucial role in regulating the immune response and inflammation. It is a negative regulator of the JAK/STAT signaling pathway, which is involved in the signaling of various cytokines and growth factors.

Research has shown that SOCS-3 is often downregulated or inactivated in various types of cancer, including breast, lung, colon, and liver cancer. This downregulation can lead to an overactivation of the JAK/STAT pathway, resulting in the promotion of cell proliferation, survival, and angiogenesis (the formation of new blood vessels).
Scientific Papers found: Click to Expand⟱
5507- Ba,    Baicalein Enhances Radiosensitivity in Colorectal Cancer via JAK2/STAT3 Pathway Inhibition
- vitro+vivo, Var, NA
RadioS↑, p‑STAT3↓, JAK2↓, PD-L1↓, SOCS-3↑,
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Src↓, p‑STAT1↓, p‑Akt↓, p‑p44↓, p‑p42↓, RAS↓, Raf↓, Vim↓, β-catenin/ZEB1↓, P53↓, Bcl-2↓, Mcl-1↓, PIAS-3↑, SOCS-3↑, SOCS1↑, ROS↑, NF-kB↓, PAO↑, SSAT↑, P21↑, Bak↑,
8131- LF,    Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma
- in-vitro, OS, HSC2 - in-vitro, OS, HSC3 - in-vitro, OS, HSC4 - in-vitro, Nor, RT7
P53↑, Akt↓, SOCS-3↑, mTOR↓, JAK↓, STAT3↓, selectivity↑, TumCP↓, Iron↓, TumCCA↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Iron↓, 1,   PAO↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

p‑p42↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

SSAT↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Bak↑, 1,   Bcl-2↓, 1,   Mcl-1↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   PIAS-3↑, 1,   RAS↓, 1,   Src↓, 1,   p‑STAT1↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Migration(tgid=13) ⓘ

p‑p44↓, 1,   TumCP↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 1,   PD-L1↓, 1,   SOCS-3↑, 3,   SOCS1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↓, 1,  
Total Targets: 35

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SOCS-3, Suppressor of Cytokine Signaling 3
1 Baicalein
1 Curcumin
1 Lactoferrin/Talactoferrin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:663  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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