ATG3 Cancer Research Results

ATG3, Autophagy-related 3: Click to Expand ⟱
Source:
Type: protein
ATG3 (Autophagy-related 3) is a protein that plays a crucial role in the process of autophagy, a cellular mechanism that involves the degradation and recycling of damaged or dysfunctional cellular components. ATG3 is involved in the regulation of autophagy.
Increased expression in: breast, lung, GBM, ovarian, prostate, panreatic, hepatocellar.
Decreased expression in: colon (associated with improved prognosis).
Scientific Papers found: Click to Expand⟱
5923- CA,  RosA,    Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study
- Review, Var, NA
TumCD↑, ROS↑, Akt↓, ATG3↑, MMP↓, Casp↑, TumCP↓, TumCCA↑, DNAdam↑, angioG↓,
471- CUR,    Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells
- in-vitro, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S
Apoptosis↑, TumAuto↑, p62↓, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, Casp9↑, PARP↑, ATG3↑, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↑,
457- CUR,    Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
TumCP↓, Apoptosis↑, TumAuto↑, P53↑, PI3K↓, P21↑, p‑Akt↓, p‑mTOR↓, Bcl-2↓, Bcl-xL↓, LC3I↓, BAX↑, Beclin-1/ATG6↑, cl‑Casp3↑, cl‑PARP↑, LC3II↑, ATG3↑, ATG5↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
7893- IVT,    Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress
- vitro+vivo, Liver, NA
TumCG↓, Apoptosis↑, BAX↑, cl‑Casp3↑, cl‑PARP↑, Cyt‑c↑, TumAuto↑, LC3II↑, ATG3↑, ATG5↑, Beclin-1/ATG6↑, ER Stress↑, IRE1↑, XBP-1↑, CHOP/DDIT3↑, GRP78/BiP↑, *chemoPv↑,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
1993- PTL,    Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer
- in-vitro, Cerv, HeLa
tumCV↓, TumAuto↑, Casp3↑, BAX↑, Beclin-1/ATG6↑, ATG3↑, ATG5↑, Bcl-2↓, mTOR↓, PI3K↓, Akt↓, PTEN↑, ROS↑, MMP↓,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   RUBCN↓, 1,   THEM4/CTMP↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   ULK1/ATG1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↓, 1,   OXPHOS↑, 1,   ROS↑, 4,   TrxR1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ATP↑, 1,   CDC2↓, 1,   CDC25↓, 1,   Insulin↓, 1,   MMP↓, 3,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATG7↑, 1,   Glycolysis↓, 2,   HK2↓, 1,   PDK1 / PDPK1↓, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 3,   mt-Apoptosis↑, 1,   BAD↑, 1,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 2,   Casp↑, 2,   Casp3↑, 2,   cl‑Casp3↑, 2,   Casp9↑, 1,   Cyt‑c↑, 2,   DR5↑, 1,   Fas↑, 1,   MAPK↓, 1,   MDM2↓, 1,   survivin↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↓, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 7,   ATG5↑, 4,   Beclin-1/ATG6↑, 6,   LAMP2↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3I↓, 1,   LC3II↑, 2,   p62↓, 1,   p62↑, 2,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑cMET↑, 1,   ERK↓, 1,   HDAC↓, 1,   IGF-1↓, 1,   mTOR↓, 2,   p‑mTOR↓, 2,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 3,   PTEN↑, 1,   STAT5↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   MMP-10↓, 1,   MMP3↓, 1,   PKCδ↓, 1,   Treg lymp↓, 1,   TSC1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   ATF4↑, 1,   EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   M2 MC↓, 1,   PD-L1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

PP2A↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioEnh↑, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   EGFR↓, 1,   GutMicro↑, 2,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

ChemoSideEff↓, 1,   PRAS40↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 118

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: ATG3, Autophagy-related 3
2 Curcumin
1 Carnosic acid
1 Rosmarinic acid
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Isovitexin
1 Licochalcone A
1 Parthenolide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:722  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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