IronCh Cancer Research Results

IronCh, Iron Chelator: Click to Expand ⟱
Source:
Type:
Iron Chelator
Scientific Papers found: Click to Expand⟱
3270- ALA,    Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis
- Trial, AD, NA
*cognitive↑, *other↝, *neuroP↑, *IronCh↑, *ROS↓, *GSH↑,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3283- ALA,    Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells
- in-vitro, Nor, NA
*TNF-α↓, *NF-kB↓, *antiOx↑, *IronCh↑, *GSSG↓, *VCAM-1↓, *E-sel↓, *ICAM-1↓, *MCP1/CCL2↓, *NF-kB↓, IKKα↓,
3284- ALA,    Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson's Disease Model Induced by 6-OHDA
- vitro+vivo, Park, NA
*antiOx↑, *IronCh↑, *neuroP↑, *ROS↓, *Iron↓, *BBB↑, *motorD↑, *GSH↑,
3437- ALA,    Revisiting the molecular mechanisms of Alpha Lipoic Acid (ALA) actions on metabolism
- Review, Var, NA
*IronCh↑, *antiOx↑, *ROS↓, *GSH↑, *NF-kB↓, *AMPK⇅, *FAO↑, *GlucoseCon↑, *PI3K↑, *Akt?,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27/CDKN1B↑, PDH↑, Glycolysis↓, ROS↑, *Synergy↑, *memory↑, *motorD↑, *GutMicro↑,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3542- ALA,    Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review
- Review, Var, NA
*antiOx↑, *VitE↑, *VitC↑, *GSH↑, *IronCh↑, *BioAv↑, *BBB↑,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
3544- ALA,    Alpha lipoic acid for dementia
- Review, AD, NA
*antiOx↑, *BBB↑, *VitC↑, *VitE↑, *GSH↑, *IronCh↑, *neuroP↑, *NO↓, *cognitive↑, *AntiAge↑, *memory↑, *ROS↓,
3541- ALA,    Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology
- Review, Var, NA
*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,
3540- ALA,    Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?
- in-vitro, Nor, NA
*lipid-P↓, *H2O2↓, *IronCh↑,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
3690- BM,    Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease
- Review, AD, NA
*ROS↓, *5LO↓, *lipid-P↓, *GPx↑, *IronCh↑, *neuroP↑, *AChE↓, *memory↑, *toxicity↓, *SOD↑, *Catalase↑, *cognitive↑, *ChAT↑, *Ach↑, *BP↓,
3785- Bor,    Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease
- Analysis, AD, NA
*Aβ↓, *antiOx↑, *IronCh↑, *PDE4↓,
7957- BuckWS,    Improving the antioxidant activity of buckwheat (Fagopyrum tataricm Gaertn) sprout with trace element water
- Study, Nor, NA
*Dose↑, *eff↑, *eff↝, *ROS↓, *IronCh↑, *SOD↑, *lipid-P↓,
7946- BuckWS,    Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7)
- Study, Nor, NA
*ROS↓, *IronCh↑, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓,
7924- BuckWS,    Antioxidant activity of tartary (Fagopyrum tataricum (L.) Gaertn.) and common (Fagopyrum esculentum moench) buckwheat sprouts
- Review, Nor, NA
*eff↑, *IronCh↑, *H2O2↓,
3874- Carno,    Effects of zinc and carnosine on aggregation kinetics of Amyloid-β40 peptide
- Review, AD, NA
*Aβ↓, *IronCh↑,
3878- Carno,    Safety and Efficacy Evaluation of Carnosine, An Endogenous Neuroprotective Agent for Ischemic Stroke
- in-vivo, Stroke, NA
*toxicity∅, *antiOx↑, *neuroP↑, *IronCh↑, *ROS↓,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *Stroke↓, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2/KDR/Flk1↓, NF-kB↓,
3870- Carno,    Could carnosine or related structures suppress Alzheimer's disease?
- Review, AD, NA
*IronCh↑, *Aβ↓, *ROS↓, *Vim↓,
3873- Carno,    Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice
- in-vivo, AD, NA
*ROS↓, *IronCh↑, *Aβ↓, *AntiAge↑, *lipid-P↓, *cognitive↑, *memory∅,
3875- Carno,    Ionophore Ability of Carnosine and Its Trehalose Conjugate Assists Copper Signal in Triggering Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Activation In Vitro
- in-vitro, AD, NA
*IronCh↑, *CREB↑, *BDNF↑, *NGF↑, *antiOx↑, *ROS↓,
6016- CGA,    Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
antiOx↑, *Bacteria↓, AntiCan↑, *Inflam↓, *cardioP↑, *AntiDiabetic↑, *GutMicro↑, *eff↑, *eff↑, *ROS↓, *IronCh↑, *neuroP↑, *AChE↓, *BChE↓, *chemoPv↑, *BioAv⇅,
6080- CHL,  VitC,    Protective Effects of Sodium Copper Chlorophyllin and/or Ascorbic Acid Against Barium Chloride-Induced Oxidative Stress in Mouse Brain and Liver
- in-vivo, Nor, NA
*neuroP↑, *MDA↓, *hepatoP↑, *IronCh↑, *ROS↓, *lipid-P↓,
3857- CUR,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*Inflam↓, *antiOx↑, *IronCh↑, *BBB↑, *ADAM10↝,
3794- CUR,    Curcumin hybrid molecules for the treatment of Alzheimer's disease: Structure and pharmacological activities
- Review, AD, NA
*GSK‐3β↓, *CDK5↓, *p‑tau↓, *IronCh↑, *ROS↓, *HO-1↑, *SOD↑, *Catalase↑, *GSH↑, *TNF-α↓, *IL6↓, *IL12↓, *NRF2↑, *PPARγ↑, *IL4↑, *AChE↓, *Dose↝, *GutMicro↑,
3579- CUR,  AgNPs,    Metal–Curcumin Complexes in Therapeutics: An Approach to Enhance Pharmacological Effects of Curcumin
- Review, Nor, NA
*IronCh↑, *BioAv↑, *antiOx↑, *Inflam↓, *BioAv↑, ROS↑, *neuroP↑, *Synergy↑,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2/PTGS2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *Synergy↑,
6210- CUR,    Potential Roles and Mechanisms of Curcumin and its Derivatives in the Regulation of Ferroptosis
- in-vitro, Var, NA
Ferroptosis↑, *Ferroptosis↓, ROS↑, Fenton↑, *IronCh↑, GPx4↓, MDA↑, GSH↓, *NRF2↑, *HO-1↑,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
3711- FA,    A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease
- Review, AD, NA
*antiOx↑, *neuroP↑, *Aβ↓, *Inflam↓, *AChE↓, *IronCh↑,
3778- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
- Review, AD, NA
*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,
3783- FA,    Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s Disease
- in-vitro, AD, NA
*ROS↓, *IronCh↑, *NLRP3↓, *Aβ↓, *AChE↓, *BChE↓, *antiOx↑, *BBB↑, *MMP↑, *memory↑, *SOD↑, *Catalase↑,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE/β-secretase↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
7720- IP6,    Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention
- Review, Nor, NA
*ROS?, *IronCh↑, *chemoPv↑,
7727- IP6,    Suppression of colonic cancer by dietary phytic acid
- Review, Nor, NA
*IronCh↑, *ROS↓, Risk↓,
7698- IP6,    Dietary Phytic Acid, Dephytinization, and Phytase Supplementation Alter Trace Element Bioavailability-A Narrative Review of Human Interventions
- Review, Nor, NA
*Iron↓, *Zn2+↓, *other↝, *IronCh↑,
9252- ISO, IH,    Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, mtDam↑, MMPs↓, VEGF↓, EMT↓, *antiOx↓, *Inflam↓, *ROS↓, MDR1↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, Ingr↝, TumCCA↑, CycB/CCNB1↓, CDK1↓, P21↑, ROS↑, AMPK↑, *Ferroptosis↓, *NRF2↑, *HO-1↑, *IronCh↑, *lipid-P↓, *GSH↑, *ACSL4↓, *COX2/PTGS2↓, VEGF↓, angioG↓, E-cadherin↑, N-cadherin↓, uPA↓, *NK cell↑, radioP↑, Imm↑, Neut↑, Eos↑,
8145- LF,    Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review
- Review, AD, NA - Review, Park, NA
*AntiBio↑, *Imm↑, *AntiCan↑, *neuroP↑, *BBB↑, *APOE4↓, *ROS↓, *Inflam↓, *Apoptosis↓, *Learn↑, *memory↑, *ADAM10↑, *PSEN1/PS1↑, *cl‑APP↑, *BACE/β-secretase↓, *cognitive↑, *MDA↓, *IL6↓, *TNF-α↓, *neuroP↑, *Dose↝, *IronCh↑, *SOD↑, *BioAv↝,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
7828- Myr,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *cognitive↑, *Aβ↓, *ADAM10↑, *BACE/β-secretase↝, *IronCh↑, *Iron↓, *AChE↓, *ROS↓,
3352- QC,    A review of quercetin: Antioxidant and anticancer properties
- Review, Var, NA
*antiOx↑, *lipid-P↓, *TNF-α↓, *NF-kB↓, *COX2/PTGS2↓, *IronCh↑, P53↓, TumCCA↑, HSPs↓, P21↓, RAS↓, ER(estro)↑, OS?,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, Var, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,

Showing Research Papers: 1 to 50 of 56
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 56

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Fenton↑, 1,   GPx4↓, 1,   GSH↓, 1,   HO-1↓, 1,   lipid-P↑, 1,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 10,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   mtDam↑, 1,   PDH↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 3,   FDG↓, 1,   Glycolysis↓, 2,   p‑GSK‐3β↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 4,   BAX↑, 3,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   DR5↑, 1,   Ferroptosis↑, 1,   iNOS↓, 1,   MDM2↓, 1,   survivin↓, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   p‑Akt↓, 1,   EGFR↓, 2,   ERK↓, 2,   IKKα↓, 1,   JNK↑, 1,   MAPK↓, 1,   MARK4↓, 1,   mTOR↓, 1,   PI3K↓, 3,   p‑PI3K↑, 1,   RAS↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cMyc↑, 1,   HDAC2↓, 1,   miR-155↓, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSPs↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3B-II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   hTERT/TERT↓, 1,   P53↓, 1,   P53↑, 1,   cl‑PARP↑, 1,   PARP1↑, 1,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 2,   P21↓, 1,   P21↑, 2,   p27/CDKN1B↑, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Gli1↓, 1,   NICD↓, 1,   NOTCH1↓, 1,   TAZ↓, 1,   TumCG↓, 1,   TumCP↓, 3,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   Ca+2↑, 1,   E-cadherin↑, 3,   EMT↓, 2,   MMP2↓, 1,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 3,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   uPA↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   EGR4↓, 1,   HIF-1↑, 1,   Hif1a↓, 1,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CXCR4↓, 1,   Eos↑, 1,   IFN-γ↓, 1,   Imm↑, 1,   Neut↑, 1,   NF-kB↓, 4,   p‑NF-kB↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER(estro)↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 3,   Half-Life↓, 1,   MDR1↓, 2,   RadioS↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 2,   hTERT/TERT↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   OS?, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 125

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 31,   ARE↑, 1,   Bil↑, 2,   Catalase↑, 8,   Fenton↓, 3,   GCLC↑, 2,   GCLM↑, 2,   GPx↑, 4,   GPx4↑, 1,   GSH↑, 20,   GSSG↓, 1,   H2O2↓, 2,   H2O2∅, 1,   HNE↓, 1,   HO-1↑, 10,   HO-2↓, 1,   Iron↓, 4,   lipid-P↓, 18,   MDA↓, 5,   MDA↑, 1,   NOX4↓, 1,   NQO1↑, 4,   NRF2↑, 16,   ROS?, 1,   ROS↓, 38,   ROS↑, 2,   SOD↑, 13,   Trx↑, 2,   VitC↑, 4,   VitE↑, 4,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 56,   TfR1/CD71↓, 2,   Zn2+↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   Acetyl-CoA↑, 1,   ACSL4↓, 2,   AMPK↑, 2,   AMPK⇅, 1,   ATP↑, 1,   FAO↑, 1,   glucose↑, 1,   GlucoseCon↑, 6,   GSK‐3β↓, 1,   LDL↓, 1,   NADPH↓, 1,   PDKs↓, 1,   SIRT2↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bcl-2↑, 1,   Ferroptosis↓, 3,   iNOS↓, 4,   p38↓, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↑, 3,   CREB↑, 1,   ERK↑, 2,   JNK↓, 1,   MAPK↑, 2,   p‑MAPK?, 1,   p‑MAPK↓, 1,   PI3K↑, 4,   PKCδ↑, 2,   PTEN↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 2,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSPs↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   Zn2+↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↓, 3,   MMP9↓, 2,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   E-sel↓, 1,   eNOS↑, 1,   Hif1a↑, 1,   NO↓, 1,   VCAM-1↓, 8,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 16,   GLUT1↑, 1,   GLUT3↑, 2,   GLUT4↑, 4,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   ICAM-1↓, 4,   IL12↓, 1,   IL1β↓, 8,   IL4↑, 1,   IL6↓, 7,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 22,   MCP1/CCL2↓, 1,   NF-kB↓, 12,   NK cell↑, 1,   NLRP3↓, 3,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 11,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 6,   AChE↓, 10,   ADAM10↑, 2,   ADAM10↝, 1,   BChE↓, 3,   BDNF↑, 2,   ChAT↑, 8,   GABA↝, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↓, 1,   cl‑APP↑, 1,   Aβ↓, 15,   BACE/β-secretase↓, 2,   BACE/β-secretase↝, 1,   PSEN1/PS1↑, 1,   tau↓, 1,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 8,   BioAv⇅, 1,   BioAv↝, 8,   Dose↑, 1,   Dose↝, 8,   eff↓, 1,   eff↑, 6,   eff↝, 1,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 2,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   Bil↑, 2,   BP↓, 1,   BP↝, 1,   BUN↓, 1,   creat↓, 1,   Ferritin↑, 1,   IL6↓, 7,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 5,   AntiCan↑, 3,   AntiDiabetic↑, 2,   cardioP↓, 1,   cardioP↑, 3,   CardioT↓, 1,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 17,   hepatoP↑, 7,   Learn↑, 1,   memory↑, 13,   memory∅, 1,   motorD↑, 3,   neuroP↑, 25,   PDE4↓, 1,   radioP↑, 1,   RenoP↑, 3,   Stroke↓, 1,   toxicity↓, 4,   toxicity∅, 2,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 5,   Sepsis↓, 2,  
Total Targets: 172

Scientific Paper Hit Count for: IronCh, Iron Chelator
17 Alpha-Lipoic-Acid
7 Curcumin
6 Carnosine
4 Ferulic acid
3 buckwheat sprouts
3 phytic acid, Inositol hexakisphosphate
3 Quercetin
3 Rosmarinic acid
2 Chlorogenic acid
1 Bacopa monnieri
1 Boron
1 Chlorophyllin
1 Vitamin C (Ascorbic Acid)
1 Silver-NanoParticles
1 Huperzine A/Huperzia serrata
1 Isorhamnetin
1 Lactoferrin/Talactoferrin
1 Luteolin
1 Myricetin
1 Mung Bean Sprouts
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:835  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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