AMPK Cancer Research Results

AMPK, adenosine monophosphate-activated protein kinase: Click to Expand ⟱
Source:
Type:
AMPK: guardian of metabolism and mitochondrial homeostasis; Upon changes in the ATP-to-AMP ratio, AMPK is activated. (AMPK) is a key metabolic sensor that is pivotal for the maintenance of cellular energy homeostasis. It is well documented that AMPK possesses a suppressor role in the context of tumor development and progression by modulating the inflammatory and metabolic pathways.

-Activating AMPK can inhibit anabolic processes and the PI3K/Akt/mTOR pathway reducing glycolysis shifting toward Oxidative Phosphorlylation.


AMPK activators:
-metformin or AICAR
-Resveratrol: activate AMPK indirectly
-Berberine
-Quercetin: may stimulate AMPK
-EGCG: thought to activate AMPK
-Curcumin: may activate AMPK

-Ginsenosides: Some ginsenosides have been associated with AMPK activation -Beta-Lapachone: A natural naphthoquinone compound found in the bark of Tabebuia avellanedae (also known as lapacho or taheebo). It has been observed to activate AMPK in certain models.
-Alpha-Lipoic Acid (ALA): associated with AMPK activation
Scientific Papers found: Click to Expand⟱
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
2318- Api,    Apigenin as a multifaceted antifibrotic agent: Therapeutic potential across organ systems
- Review, Nor, NA
*ROS↓, *PKM2↓, *Hif1a↓, *TGF-β↓, *AMPK↑, *Inflam↓, *PI3K↓, *Akt↑, *NRF2↑, *NF-kB↓,
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1/CCL2↓, *MIP2↓, *TGF-β↑, *Inflam↓,
3164- Ash,    Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
- in-vitro, Nor, NA
*hepatoP↑, *IKKα↓, *NLRP3↓, *NRF2↑, *AMPK↑, *Inflam↓, *Apoptosis↓, *cl‑Casp3↓, *cl‑PARP1↓, *NLRP3↓, *ROS↓, *ALAT↓, *AST↓, *GSH↑,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, Synergy↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, ChemoSen↑,
4305- Ba,    Study on the Molecular Mechanism of Baicalin Phosphorylation of Tau Protein Content in a Cell Model of Intervention Cognitive Impairment
- in-vitro, AD, SH-SY5Y
*cognitive↑, *p‑Akt↑, *p‑GSK‐3β↑, *p‑tau↓, *neuroP↑, *NF-kB↓, *AMPK↑, *NRF2↑,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2389- BA,    Baicalin alleviates lipid accumulation in adipocytes via inducing metabolic reprogramming and targeting Adenosine A1 receptor
- in-vitro, Obesity, 3T3
*ECAR↑, *OCR↓, *p‑AMPK↑, *p‑ACC↑, *Glycolysis↑, *lipidDe↓, *SREBP1/SREBF1↓, *FAO↑, *HK2↑, *PKM2↑, *LDHA↑, *PDKs↓, *ACC↓,
5552- BBM,    Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosine monophosphate‐activated protein kinase/nuclear factor erythroid 2‐related factor pathway and changes in the mitochondrial state
- in-vivo, Stroke, NA
*eff↑, *ROS↓, *mtDam↓, *AMPK↑, *NRF2↑, *NADPH↑, *HO-1↑, *cardioP↑,
2696- BBR,    Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway
- in-vivo, Nor, NA
*α-SMA↓, *TGF-β1↓, *IL10↑, *p‑AMPK↑, *p‑mTOR↓, *P70S6K↓, *cardioP↑,
2671- BBR,    Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action
- in-vivo, Diabetic, NA
*BioAv↓, *Half-Life↝, *OCR↓, *AMPK↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1/ATG6↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2/PTGS2↓, *p62↓, *NP/CIPN↓,
2739- BetA,    Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, Nor, MEF
*Glycolysis↑, *GlucoseCon↑, *Apoptosis↓, *UCP1↓, *AMPK↑, GLUT1↑, mt-ROS↑,
699- Bor,    Boric Acid Alleviates Gastric Ulcer by Regulating Oxidative Stress and Inflammation-Related Multiple Signaling Pathways
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *TNF-α↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *Sema3A/PlexinA1↑,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
5834- CAP,    Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
- Study, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *TRPV1↑, *AMPK↑, *SIRT1↑, *NADPH↓, *ROS↓, *MAPK↓, *eNOS↑, *Wnt/(β-catenin)↓, RenoP↑,
2348- CAP,    Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
- Analysis, Nor, NA
Warburg↓, *PKM2↓, *COX2/PTGS2↓, *Inflam↓, *Sepsis↓, *AMPK↑, *PKA↑, *mitResp↑, *FAO↑, *FASN↓, *PGM1?, *ATP↑, *ROS↓,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *Stroke↓, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6622- Cic,    Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and Extends Lifespan in Caenorhabditis elegans
- in-vivo, Nor, NA
*ROS↓, *AMPK↑, *GPx↑, *SOD↑, *SOD2↑, *PGC-1α↑, *Akt↓, *mTOR↓, *Insulin↓, *antiOx↑, *AntiAge↑,
5780- CRMs,  HCAs,  RES,  Sper,  ASA  Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential
- Review, Var, NA
*OS↑, *AntiAge↑, *cardioP↑, *neuroP↑, AntiCan↑, *TNF-α↓, *Weight↓, *BP↓, *Inflam↓, *Insulin↓, *ROS↓, *AMPK↑, *mTOR↓, *SIRT1↑, CRM↑,
5792- CRMs,  HCA,  CUR,  EGCG,  GAR  Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
- Review, Nor, NA
*CRM↓, *Dose?, *AntiAge↑, *Acetyl-CoA↓, *SIRT1↑, *AMPK↑, *mTORC1↓, *AntiAge↑, chemoP↑,
5798- CRMs,    Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders
- Review, Nor, NA - Review, AD, NA
*GutMicro↑, *neuroP↑, *eff↑, *Dose↝, *AMPK↑, *SIRT1↑, *mTOR↓, *NRF2↑, *p‑tau↓,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2/PTGS2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE/β-secretase↓, *AChE↓, *LDL↓,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2/PTGS2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1/CCL2↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *Synergy↑, Synergy↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
3708- dietSTF,    Fasting as a Therapy in Neurological Disease
- Review, Nor, NA
*PGC-1α↑, *AMPK↑, *adiP↑, *glucose↓, *Insulin↓, *mTOR↓, *IL6↓, *TNF-α↓, *cognitive↑, *Inflam↓, *eff↑, *neuroP↑, ChemoSen↑, eff↓, chemoP↑, *eff↑,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
7207- GBE,    The molecular mechanisms of ginkgo (Ginkgo biloba) activity in signaling pathways: A comprehensive review
- Review, AD, NA
*Inflam↓, *Apoptosis↓, *neuroP↑, *cardioP↑, *hepatoP↑, *AntiViral↑, *Bacteria↓, *RenoP↑, *ROS↓, *NADPH↓, *MAPK↓, *ERK↓, *JNK↓, *AP-1↓, *cAMP↑, *STAT5↓, *AMPK↑,
3766- H2,    The role of hydrogen in Alzheimer′s disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *AMPK↑, *SIRT1↑, *FOXO↑, *mtDam↓, *neuroP↑, *ROS↓, *p38↓, *cognitive↑, *BDNF↑, *memory↑, *lipid-P↓, *IL6↓, *TNF-α↓, *JNK↓, *NF-kB↓, *NLRP3↓,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *BP∅, *BBB↑,
3776- H2,    The role of hydrogen in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *NLRP3↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *ROS↓, *BDNF↑,
3774- H2,    The role of hydrogen in Alzheimer’s disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *memory↑, *Aβ↓, *AMPK↑, *SIRT1↑, *FOXO3↑, *p‑p38↓, *JNK↓, *ROS↓, *cognitive↑, *ER(estro)↑, *BDNF↑,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
7710- IBC,    Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice
- vitro+vivo, AD, NA
*p‑AMPK↑, *NLRP3↓, *NA↝, *cognitive↑, *memory↑, *motorD↑, *Aβ↓, *Inflam↓, *BBB↑,
7636- Ins,    Myo-Inositol: Pharmacokinetics, Biological Functions, and Therapeutic Potential in Liver Protection: Insights from Preclinical Models
- Review, Nor, NA
*glucose↝, *lipid-P↓, *ROS↓, *BioAv↑, *hepatoP↑, *Inflam↓, *MMP↑, *ATP↑, *GutMicro↑, *Dose↝, *Half-Life↝, *BioAv↑, *Synergy↑, *hepatoP↑, *SOD↑, *Catalase↑, *Casp3↓, *ALAT↓, *AST↓, *AMPK↑, *SREBP1/SREBF1↑, NA↑,
7876- isoO,    Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway
- in-vitro, Nor, NA
*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,
7800- ISQ,    Isoquercitrin Attenuates Oxidative Liver Damage Through AMPK-YAP Signaling: An Integrative In Silico, In Vitro, and In Vivo Study
- vitro+vivo, Nor, HepG2
*antiOx↑, *Inflam↓, *AntiCan↑, *ROS↓, *MMP↑, *STK11/LKB1↑, *AMPK↑, *p‑AMPK↑, *ACC↑, *ALAT↓, *AST↓, *hepatoP↑,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
9062- L-THE,    Therapeutic Role of l‑Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *AntiAge↑, *Dose?, *AMPK↑, *LC3II↑, *Beclin-1/ATG6↑, *p‑Akt↓, *p‑mTOR↓, *BDNF↑, *Casp3↓, *GSH↑, *MDA↓, *TNF-α↓, *Aβ↓, *Learn↑, *memory↑, *ROS↓,
9009- L-THE,    Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *AntiAge↑, *Dose↝, *AMPK↑, *LC3II↑, *Beclin-1/ATG6↑, *p‑Akt↓, *p‑mTOR↓, *BDNF↑, *Casp3↓, *GSH↑, *MDA↓, *TNF-α↓, *Aβ↓, *Learn↑, *memory↑, *ROS↓,
8155- lamb,    Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)
- vitro+vivo, Nor, 3T3
*p‑AMPK↑, *PPARγ↓, *CEBPA↓, *adiP↓, *Fas↓, *SREBP1/SREBF1↓, *HMGCR↓, *lipidLev↓, *TG/TAG↓, *Weight↓, *LDL↓, *Obesity↓,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, Synergy↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
4338- LT,    Luteolin: a natural product with multiple mechanisms for atherosclerosis
- Review, Var, NA
*Inflam↓, *ROS↓, *PDGF↓, *lipid-P↓, *AMPK↑, *SIRT1↑, *AntiAg↑,
3265- Lyco,    Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
- in-vitro, Nor, NA
*AMPK↑, *mTOR↓, *NLRP3↓, *Pyro↓,
8492- MAG,    Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway
- in-vivo, AD, NA
*Apoptosis↑, *cl‑Casp9↓, *BAX↓, *Bcl-2↓, *p62↓, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ULK1/ATG1↑,

Showing Research Papers: 1 to 50 of 85
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 85

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 2,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 2,   ROS↑, 8,   mt-ROS↑, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 2,   ETC↓, 1,   mitResp↓, 1,   mtDam↑, 2,   OXPHOS↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ACC↑, 1,   ACLY↓, 1,   AMP↑, 1,   AMPK↑, 2,   ATP↓, 1,   CRM↑, 1,   FASN↓, 1,   glucoNG↓, 1,   Glycolysis↓, 1,   Glycolysis↝, 1,   p‑GSK‐3β↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis?, 1,   Apoptosis↑, 7,   BAX↑, 5,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Bcl-xL↓, 1,   BNIP3↑, 1,   Casp↑, 1,   Casp3↑, 4,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 1,   Fas↑, 1,   MOMP↑, 1,   survivin↓, 1,   TumCD↑, 1,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   p‑Akt↓, 1,   EGFR↓, 1,   ERK↓, 1,   JAK↓, 1,   JNK↑, 1,   MAPK↓, 1,   mTOR↓, 5,   PI3K↓, 6,   p‑PI3K↓, 1,   PKCδ↓, 1,   STAT↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 1,   cJun↓, 1,   cMyc↓, 5,   FOXM1↓, 1,   FOXO3↑, 1,   miR-34a↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 4,   p‑P53↓, 1,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 4,   CDK6↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   Ki-67↓, 1,   P21↓, 1,   p27/CDKN1B↓, 2,   pRB↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD133↑, 1,   cFos↓, 1,   CSCs?, 1,   CSCs↓, 3,   Ki-67↓, 1,   NOTCH3↓, 1,   TumCG↓, 4,   TumCP↓, 6,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 2,   EMT↝, 1,   MMP2↓, 1,   MMP9↓, 2,   N-cadherin↓, 2,   TumCI↓, 2,   TumMeta↓, 5,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 3,   VEGF↓, 5,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↑, 1,   MMP↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD8+↑, 1,   COX2/PTGS2↓, 2,   DCells↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   IL1↓, 1,   IL12↓, 1,   IL2↓, 1,   IL6↓, 5,   IL8↓, 2,   Imm↑, 2,   MCP1/CCL2↓, 1,   NF-kB↓, 5,   p‑NF-kB↓, 1,   ac‑p65↓, 1,   PD-L1↓, 1,   PSA↓, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 7,   eff↓, 1,   eff↑, 2,   RadioS↑, 3,   selectivity↑, 1,   Synergy↑, 4,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 1,   FOXM1↓, 1,   IL6↓, 5,   LDH↓, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 3,   AntiTum↑, 1,   Appetite↑, 1,   BowelM↑, 1,   breath↑, 1,   chemoP↑, 4,   hepatoP↑, 3,   neuroP↑, 1,   NP/CIPN↓, 1,   OS↑, 2,   OS⇅, 1,   OS∅, 1,   Pain↓, 2,   PFS∅, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   Sleep↑, 1,   Strength↑, 2,   toxicity↓, 2,   Weight↑, 1,  
Total Targets: 177

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 29,   Catalase↑, 10,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 6,   GPx4↑, 1,   GSH↑, 18,   GSH/GSSG↑, 1,   GSR↑, 2,   GSTs↑, 1,   H2O2↓, 1,   H2O2∅, 1,   HO-1↑, 17,   Keap1↓, 1,   lipid-P↓, 16,   mt-lipid-P↓, 1,   lipidDe↓, 1,   MDA↓, 13,   MPO↓, 3,   NQO1↑, 5,   NRF2↑, 28,   RNS↓, 1,   ROS↓, 53,   ROS↑, 1,   SOD↑, 18,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 3,   TOS↓, 1,   Trx1↑, 1,   TrxR1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   Insulin↓, 4,   MFN2↑, 1,   mitResp↑, 1,   mtDam↓, 5,   OCR↓, 2,   PGC-1α↓, 1,   PGC-1α↑, 6,   PINK1↑, 1,   SIRT3↑, 2,   TFAM↑, 1,   UCP1↓, 1,   VDAC1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ACC↑, 1,   p‑ACC↑, 1,   Acetyl-CoA↓, 2,   adiP↓, 1,   adiP↑, 1,   ALAT↓, 13,   AMPK↑, 79,   p‑AMPK↑, 8,   ATP↑, 7,   cAMP↑, 1,   CPT1A↑, 1,   CRM↓, 1,   CRM↑, 4,   ECAR↑, 1,   FAO↑, 3,   FASN↓, 1,   FFA/NEFA↓, 1,   G6PD↑, 1,   glucoNG↓, 1,   glucose↓, 7,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 4,   GlutMet↑, 1,   glyC↓, 1,   Glycolysis↑, 2,   GSK‐3β↓, 5,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 2,   HK2↑, 1,   LDHA↑, 1,   LDL↓, 3,   lipidLev↓, 2,   lipoGen↓, 1,   NADH:NAD↑, 1,   NADPH↓, 5,   NADPH↑, 1,   PDKs↓, 1,   PGM1?, 1,   PKM2↓, 2,   PKM2↑, 1,   SCD1↓, 1,   SIRT1↑, 26,   SIRT1↝, 1,   SREBP1/SREBF1↓, 4,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 9,   Apoptosis↑, 1,   ASC↓, 1,   BAX↓, 4,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-2↑, 2,   Casp↓, 1,   Casp1↓, 2,   Casp3↓, 8,   Casp3↑, 1,   cl‑Casp3↓, 1,   Casp8↓, 1,   Casp9↓, 2,   cl‑Casp9↓, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Fas↓, 3,   Ferroptosis↓, 3,   iNOS↓, 7,   necrosis↓, 1,   p38↓, 1,   p38↑, 1,   p‑p38↓, 2,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   Akt↑, 8,   p‑Akt↓, 3,   p‑Akt↑, 2,   p‑CREB↑, 1,   ERK↓, 2,   ERK↑, 2,   p‑ERK↓, 1,   p‑ERK↑, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↓, 2,   JNK↓, 5,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 8,   MAPK↑, 2,   mTOR↓, 11,   mTOR↑, 2,   p‑mTOR↓, 4,   P70S6K↓, 2,   PI3K↓, 3,   PI3K↑, 4,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PKA↑, 2,   PKCδ↑, 2,   PP2A↑, 3,   PTEN↓, 2,   PTEN↑, 2,   STAT↓, 1,   STAT3↓, 3,   STAT5↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↑, 1,   ATF4↓, 1,   FOXO↑, 2,   FOXO1↝, 1,   FOXO3↑, 4,   miR-155↓, 1,   other↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 3,   ER Stress↓, 4,   ER Stress↑, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   IRE1↓, 2,   NQO2↑, 1,   PDI↓, 1,   PERK↓, 1,   p‑PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↑, 4,   MitoP↑, 2,   p62↓, 4,   p62↑, 1,   PARK2↑, 4,   ULK1/ATG1↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   cl‑PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   P21↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   HH↓, 1,   HMGCR↓, 1,   IGF-1↓, 1,   mTORC1↓, 1,   neuroG↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 3,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Cartilage↑, 2,   COL1↓, 1,   COL1↑, 1,   MMP3↓, 1,   MMP9↓, 6,   PDGF↓, 1,   Sema3A/PlexinA1↑, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 2,   TGF-β↑, 2,   TGF-β1↓, 1,   TXNIP↓, 3,   α-SMA↓, 2,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   E-sel↓, 1,   eNOS↑, 3,   Hif1a↓, 3,   NO↓, 5,   VCAM-1↓, 4,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 8,   BBB↝, 1,   GastroP↑, 1,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 4,   H+/K+-ATPase↓, 1,   MMP↓, 1,   MMP↑, 10,   TRPC1↓, 1,   TRPV1↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 10,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL10↑, 3,   IL17↓, 1,   IL18↓, 2,   IL1β↓, 13,   IL2↓, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 16,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 49,   MCP1/CCL2↓, 2,   MIP2↓, 1,   mPGES-1↓, 1,   MyD88↓, 1,   NF-kB↓, 27,   NLRP3↓, 18,   NLRP3↑, 1,   p65↓, 1,   PGE2↓, 4,   TLR4↓, 6,   TNF-α↓, 19,   TNF-α↑, 1,   β-HEX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 1,   AChE↓, 7,   ADAM10↑, 1,   BChE↓, 1,   BDNF↑, 8,   β-Endo↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 17,   BACE/β-secretase↓, 5,   BACE/β-secretase↑, 1,   tau↓, 1,   p‑tau↓, 9,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   PPARα↑, 2,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 4,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 9,   BioAv↝, 8,   BioEnh↑, 2,   CYP2E1↓, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 1,   Dose↝, 9,   eff↓, 1,   eff↑, 8,   Half-Life↓, 2,   Half-Life↝, 9,   P-gp/ABCB1↓, 1,   P450↓, 1,   P450↝, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 13,   ALP↓, 3,   AST↓, 11,   BG↓, 1,   BloodF↑, 1,   BMD↑, 4,   BP↓, 4,   BP↝, 1,   BP∅, 1,   CRP↓, 2,   IL6↓, 16,   IRes↑, 1,   IRes↝, 1,   LDH↓, 2,   TG/TAG↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 13,   antiAll↑, 2,   AntiCan↑, 4,   AntiDiabetic↑, 8,   AntiTum↑, 1,   cardioP↑, 15,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 20,   diuretic↑, 1,   hepatoP↑, 20,   Learn↑, 2,   memory↑, 16,   motorD↑, 5,   neuroP↑, 38,   NP/CIPN↓, 1,   Obesity↓, 7,   OS↑, 4,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 4,   Risk↓, 3,   Strength↑, 4,   Stroke↓, 3,   toxicity↓, 2,   toxicity⇅, 1,   toxicity↝, 3,   toxicity∅, 1,   Weight↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 4,   GutMicro↑, 10,   Sepsis↓, 3,  
Total Targets: 353

Scientific Paper Hit Count for: AMPK, adenosine monophosphate-activated protein kinase
13 Resveratrol
5 Hydrogen Gas
5 Metformin
4 Urolithin
3 Berberine
3 Calorie Restriction Mimetics
3 Curcumin
3 Quercetin
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Boron
2 Capsaicin
2 Emodin
2 Kaempferol
2 L-Theanine
2 lambertianic acid
2 Luteolin
2 Magnetic Field Rotating
2 Magnetic Fields
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Baicalin
1 Berbamine
1 Beta-Caryophyllene
1 Cannabidiol
1 Betulinic acid
1 Chlorogenic acid
1 Cichoric acid / Chicoric acid
1 Hydroxycinnamic-acid
1 Spermidine
1 Aspirin
1 HydroxyCitric Acid
1 EGCG (Epigallocatechin Gallate)
1 Garcinol
1 diet Short Term Fasting
1 Ginkgo biloba
1 Isobavachalcone
1 Inositol
1 isoorientin
1 isoquercitrin
1 Licochalcone A
1 Lycopene
1 Magnolol
1 Methyl salicylate / Sweet Birch oil
1 Patchouli Oil (Pogostemon cablin)
1 Piperine
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Salvia miltiorrhiza
1 Terminalia bellirica
1 Gallic acid
1 Vitexin
1 Isovitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:9  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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