NLRP3 Cancer Research Results

NLRP3, NOD-like receptor pyrin domain-containing protein 3: Click to Expand ⟱
Source:
Type:
NLRP3 (NOD-like receptor pyrin domain-containing protein 3) is a protein that plays a crucial role in the regulation of inflammation and immune responses.
NLRP3 typically has high expression in cancers, with poor prognosis.
For alzheimer's disease:
-NLRP3 is upregulated in Alzheimer's disease (AD)
-NLRP3 is activated in microglia in response to amyloid-β (Aβ) and tau aggregates.
-Promotes tau hyperphosphorylation and spread via inflammation-driven pathways.
Scientific Papers found: Click to Expand⟱
6108- Chol,    Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health
- Review, Nor, NA - Review, AD, NA
*TMAO↑, *ROS↑, *NADPH↑, *Ca+2↑, *AntiAg↓, *cognitive↓, *TJ↓, *CLDN1↓, *ZO-1↓, *Inflam↑, *NLRP3↑, *ER Stress↑, *cognitive↓, *Dose↝, *eff↑, *other↝, *other↝, *other↝,
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2/KDR/Flk1↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,
4345- H2,    The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease
- Human, Var, NA
*Inflam↓, *antiOx↑, *ROS↓, *NLRP3↑, *NF-kB↓, *SOD↑, *Catalase↑, *AntiAg↑,
8707- MET,    Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
- Review, Var, NA - Review, AD, NA
*BioAv↝, *cardioP↑, *Obesity↓, *neuroP↑, *toxicity↝, *Dose↝, *GutMicro↑, *AMPK↑, *glucose↓, *NLRP3↑, *Inflam↓, *Stroke↓, *Cartilage↑, FOXP3↑, TumAuto↑, mTOR↓, PD-L1↓, RadioS↑, ChemoSen↑, ROS↓, OXPHOS↓, compI↓, Glycolysis↝, TumCP↓, *BioAv↝, *AntiAge↑, *SIRT1↑, *cognitive↑, *Risk↓, Ki-67↓, Synergy↝, PFS∅, OS∅,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↝, 1,  

Cell Death(tgid=5) ⓘ

YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   CIP2A↓, 1,   MAPK↓, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMTs↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,   NOTCH↓, 1,   TumCG↓, 1,   TumCP↓, 2,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

FAK↑, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

FOXP3↑, 1,   NLRP3↑, 1,   PD-L1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 1,   Half-Life↝, 1,   RadioS↑, 1,   selectivity∅, 1,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS∅, 1,   PFS∅, 1,   toxicity↝, 1,  
Total Targets: 38

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ARE↑, 1,   Catalase↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 2,   ROS↑, 1,   SOD↑, 2,   SOD1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   glucose↓, 1,   NADPH↑, 1,   SIRT1↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

STAT↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AntiAg↑, 1,   Ca+2↑, 1,   Cartilage↑, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   TJ↓, 1,   ZO-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 3,   Inflam↑, 1,   NF-kB↓, 2,   NLRP3↑, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↝, 2,   Dose↝, 2,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

TMAO↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   cardioP↑, 1,   cognitive↓, 2,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 2,   Obesity↓, 1,   Risk↓, 1,   Stroke↓, 1,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 46

Scientific Paper Hit Count for: NLRP3, NOD-like receptor pyrin domain-containing protein 3
1 Choline
1 Cucurbitacin
1 Hydrogen Gas
1 Metformin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:908  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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