CPT1A Cancer Research Results

CPT1A, Carnitine Palmitoyltransferase 1A: Click to Expand ⟱
Source:
Type:
Carnitine Palmitoyltransferase 1A (CPT1A) is an enzyme that plays a crucial role in the regulation of fatty acid metabolism, particularly in the transport of long-chain fatty acids into mitochondria for beta-oxidation. In cancer, CPT1A has been implicated in the regulation of tumor cell metabolism, proliferation, and survival.

CPT1A typically overexpressed and is associated with poor prognosis and reduced overall survival in breast, lung, and colon cancers.
CPT1A expression is also associated with increased risk of metastasis and recurrence in various types of cancer.
Scientific Papers found: Click to Expand⟱
7779- ISL,    Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury
- in-vivo, Alcohol, NA
*hepatoP↑, *FAM↑, *PGC-1α↑, *PPARα↑, *CPT1A↑, *ACADS/SCAD↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *miR-23a-3p↓,
9249- ISO, IH,    Isorhamnetin alleviates cisplatin-induced acute kidney injury via enhancing fatty acid oxidation
- in-vivo, Nor, NA
*chemoP↑, *Apoptosis↓, *Inflam↓, *RenoP↑, *lipidLev↓, *PGC-1α↑, *PPARα↑, *CPT1A↑, *FAO↑,
9058- PatchO,    Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation
- in-vivo, LiverDam, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *LDH↓, *ROS↓, *TNF-α↓, *FFA/NEFA↓, *TG/TAG↓, *GSH↑, *GSR↑, *SOD↑, *GSH/GSSG↑, *AMPK↑, *PPARα↑, *CPT1A↑, *NF-kB↓, *SREBP1/SREBF1↓, *Fas↓, *SCD1↓, *lipid-P↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↑, 1,   GSH/GSSG↑, 1,   GSR↑, 1,   lipid-P↓, 1,   ROS↓, 2,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACADS/SCAD↑, 1,   ALAT↓, 1,   AMPK↑, 1,   CPT1A↑, 3,   FAM↑, 1,   FAO↑, 1,   FFA/NEFA↓, 1,   lipidLev↓, 1,   SCD1↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Fas↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-23a-3p↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   IL6↓, 1,   LDH↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   hepatoP↑, 2,   RenoP↑, 1,  
Total Targets: 35

Scientific Paper Hit Count for: CPT1A, Carnitine Palmitoyltransferase 1A
1 Isoliquiritigenin
1 Isorhamnetin
1 Patchouli Oil (Pogostemon cablin)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:956  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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