CLDN1 Cancer Research Results

CLDN1, claudin-1: Click to Expand ⟱
Source:
Type: gene
The CLDN1 gene (Claudin-1) is a tight junction protein that plays a crucial role in maintaining epithelial barrier function and regulating cell-cell adhesion.

Breast cancer: Elevated in 50% of breast cancer, associated with poor prognosis
Lung cancer: Elevated in 60% of lung cancer tissues, associated with poor prognosis
Colorectal cancer: Elevated in 70%, associated with poor prognosis
Prostate cancer: REDUCED in 40%, and associated with poor prognosis
Ovarian cancer: Elevated in 55%, associated with poor prognosis
Gastric cancer:Elevated in 60%, associated with poor prognosis
Hepatocellular carcinoma:Elevated in 65%, associated with poor prognosis
Pancreatic cancer: Elevated in 75%, associated with poor prognosis
Scientific Papers found: Click to Expand⟱
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2/PTGS2↓, eff↝, eff↑, other↝,
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2/PTGS2↓, *IFN-γ↓, IL1β↓, ADAM10?,
9157- MG, MIC-1,    Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice
- in-vivo, Col, NA
*colonLen↑, *TNF-α↓, *NO↓, *MPO↓, *IL1↓, *IL6↓, *iNOS↓, *CLDN1↑, *ZO-1↑, *GSTP1/GSTπ↑, *NRF2↑, *eff↑,
9054- PatchO,    Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis
- in-vivo, Col, NA
*TNF-α↓, *IFN-γ↓, *IL1β↓, *IL6↓, *IL17↓, *iNOS↓, *COX2/PTGS2↓, *TJ↑, *ZO-1↑, *CLDN1↑, *OCLN↑, *MUC1↑, *MUC2↑, *Inflam↓, *IBI↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↓, 1,   ac‑H4↓, 1,   HDAC↓, 1,   other↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 2,   IL6↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 2,   eff↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   GSH↑, 1,   MPO↓, 1,   NRF2↑, 2,   ROS↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 3,   iNOS↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HCAR2↑, 1,  

Migration(tgid=13) ⓘ

MUC1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↑, 4,   CLDN3↑, 1,   IBI↑, 2,   MUC2↑, 1,   OCLN↑, 2,   TJ↑, 1,   ZO-1↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   HCAR2↑, 1,   IFN-γ↓, 2,   IL1↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL6↓, 3,   Inflam↓, 3,   NF-kB↓, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,   eff↑, 1,   GSTP1/GSTπ↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

colonLen↑, 1,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 36

Scientific Paper Hit Count for: CLDN1, claudin-1
1 Butyrate
1 Carvacrol
1 Moringin
1 Patchouli Oil (Pogostemon cablin)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:968  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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