SREBF2 Cancer Research Results

SREBF2, Sterol Regulatory Element Binding Factor 2: Click to Expand ⟱
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The SREBF2 gene (Sterol Regulatory Element Binding Factor 2) is a key regulator of lipid metabolism, particularly in the synthesis of cholesterol and fatty acids. The SREBF2 gene is overexpressed in various types of cancer.

SREBF2 gene is a key regulator of lipid metabolism and is overexpressed in various types of cancer. Its expression is associated with poor prognosis and increased risk of metastasis and recurrence.
Scientific Papers found: Click to Expand⟱
8844- DIM,  I3C,    Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Imm↝, *BioAv↝, *Half-Life↝, *PKCδ↓, *TGF-β1↓, *PPARγ↓, *CEBPA↓, *FABP4↓, *AMPKα↑, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, *Akt↑, *Inflam↓, *TMAO↓, *SREBF2⇅, *memfluid↑, *GutMicro↑, *Obesity↓, *hepatoP↑, *neuroP↑, *AntiAg↓, *Stroke↓, *AntiAg↓, *HDAC↑, *IL1β↓, *IL6↓, *iNOS↓, *IL4↑, *IL10↑, *Synergy↑, *compI↑, *ROS↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *cognitive↑, *Analgesic↑, *Pain↓, *BDNF↑, *TrkB↑, *Akt↑, *antiOx↑, *Apoptosis↓, *cardioP↑, *chemoP↑, *AntiThr↑, *uPA↑, *NRF2↑, *ARE↑, *HO-1↑, *Bacteria↓, *TOP1↓, *AntiFungal↑, *AntiViral↑, *radioP↑, *Synergy↑, *hepatoP↑, *Diar↓, *ChemoSen↑, *Telomerase↓, *BioAv↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ARE↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FABP4↓, 1,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   AMPKα↑, 1,   PKCδ↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   HDAC↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

Telomerase↓, 1,   TOP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   TGF-β1↓, 1,   uPA↑, 1,  

Barriers & Transport(tgid=15) ⓘ

memfluid↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↑, 1,   IL1β↓, 1,   IL4↑, 1,   IL6↓, 2,   Imm↝, 1,   Inflam↓, 2,   MCP1/CCL2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,   BDNF↑, 1,   MAOA↓, 1,   MAOB↓, 1,   TrkB↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↝, 1,   ChemoSen↑, 1,   Half-Life↝, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 2,   TMAO↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   neuroP↑, 1,   Obesity↓, 1,   Pain↓, 1,   radioP↑, 1,   Stroke↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,   Diar↓, 1,   GutMicro↑, 1,  
Total Targets: 59

Scientific Paper Hit Count for: SREBF2, Sterol Regulatory Element Binding Factor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:959  State#:%  Dir#:3
  wNotes=0  sortOrder:rid,rpid

 

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