toxicity Cancer Research Results

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Toxicity
Scientific Papers found: Click to Expand⟱
5310- 5-HTP,    5-Hydroxytryptophan toxicity successfully treated by haemodialysis in a dog
- Case Report, Nor, NA
*Dose↑, *toxicity↝,
5298- 5-HTP,    Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa
- Human, AD, NA
*BioAv↑, *Dose↝, *toxicity↝,
5295- 5-HTP,    Safety of 5-hydroxy-L-tryptophan
- in-vivo, Nor, NA
*5HT↑, *toxicity↝, *toxicity↓,
5289- 5-HTP,    5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology
- Review, AD, NA - Review, Arthritis, NA
*5HT↑, *Inflam↓, *memory↑, *Sleep↑, *Weight↓, *DNAdam↓, *ROS↓, *toxicity↝,
5301- 5-HTP,    Eosinophilia-myalgia syndrome presenting with overlapping features of eosinophilic fasciitis and sarcoidal granulomas
- Case Report, Nor, NA
*toxicity↝, *toxicity↝,
5300- 5-HTP,    The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice
- Review, Nor, NA
*toxicity↝,
5299- 5-HTP,    Serotonin Syndrome from 5-Hydroxytryptophan Supplement Ingestion in a 9-Month-Old Labrador Retriever
- Case Report, AD, NA
*toxicity↝, *toxicity↝,
5307- 5-HTP,    5-Hydroxytryptophan toxicosis in dogs: 1989-1999
- Case Report, Nor, NA
*toxicity↝, *5HT↑, *Dose↝,
5305- 5-HTP,    An Investigation of the Cause of the Eosinophilia–Myalgia Syndrome Associated with Tryptophan Use
- Review, Nor, NA
*toxicity↝, *toxicity↝,
5456- AF,    Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent
- Trial, Nor, NA
*Dose?, *Half-Life↝, *Dose↑, *toxicity↝, *Bacteria↓, *Dose↑,
4561- AgNPs,  VitC,    Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts
- in-vitro, CRC, HCT116 - in-vitro, Nor, HEK293
NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP/DDIT3↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,
4553- AgNPs,    Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types
- in-vitro, Nor, RAW264.7
*Wound Healing↑, *eff↝, *toxicity↝,
4577- AgNPs,    Characterization of Antiplatelet Properties of Silver Nanoparticles
- vitro+vivo, Stroke, NA
*AntiAg↑, *Bacteria↓, *Dose↝, *Dose↝, *Dose↝, *toxicity↝,
5144- AgNPs,    Differential effects of silver nanoparticles on DNA damage and DNA repair gene expression in Ogg1-deficient and wild type mice
- in-vivo, Nor, NA
*DNAdam↑, *toxicity↝, eff↝,
4402- AgNPs,    Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors
- in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,
4361- AgNPs,  GoldNP,    Biocompatible silver, gold and silver/gold alloy nanoparticles for enhanced cancer therapy: in vitro and in vivo perspectives
- in-vivo, Liver, HepG2
TumCD↑, TumVol↓, *toxicity↝, hepatoP↑,
4429- AgNPs,    Comparative proteomic analysis reveals the different hepatotoxic mechanisms of human hepatocytes exposed to silver nanoparticles
- in-vitro, Liver, HepG2
*toxicity↝, selectivity↑, mt-ROS↑,
4363- AgNPs,    Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma
- in-vivo, fibroS, NA
TumVol↓, TNF-α↓, IL6↓, IL1β↓, *toxicity↝, TumCG↓, selectivity↑, selectivity↑, Weight↑, ROS↑, NO↑,
2205- AgNPs,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
5366- AV,    Aloe vera: A review of toxicity and adverse clinical effects
- Review, Var, NA
*Dose↝, *toxicity↝, tumCV↓, *AntiAg↑,
9174- BITC,    Benzyl isothiocyanate as an alternative to antibiotics? a comparative in vivo study using Pseudomonas aeruginosa
- in-vivo, Nor, NA
*AntiBio↑, *eff↑, *toxicity↝,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp/ABCB1↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5899- CAR,  TV,    Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Synergy↑, selectivity↑, BioAv↝, BBB↑, *toxicity↝, *antiOx↑, COX2/PTGS2↓, 5LO↓,
6138- CHr,  Cisplatin,    Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: Probable role of p38MAPK and p53
- in-vivo, Nor, NA
*toxicity↝, eff↑, chemoP↑, *ROS↓, *MAPK↑, *P53↑, GSH↓,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, Synergy↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, Synergy↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
4769- CoQ10,    CoQ10 Is Key for Cellular Energy and Cancer Support
- Review, Var, NA
Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,
1571- Cu,    Copper in cancer: From pathogenesis to therapy
- Review, Var, NA
*toxicity↝, ROS↑, lipid-P↓, HNE↑, MAPK↑, JNK↑, AP-1↑, Beclin-1/ATG6↑, ATG7↑, TumAuto↑, Apoptosis↑, HO-1↑, NQO1↑, mt-ROS↑, Fenton↑,
1596- Cu,  CDT,    Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review
- Review, Var, NA
TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,
6185- Cuc,    Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
- Review, Var, NA - Review, Arthritis, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *AntiCan↑, *toxicity↝, *BioAv↓, *HO-1↑, *NRF2↑, *NLRP3↑, *SOD↑, *SOD1↑, *ROS↓, *AntiAge↑, *ARE↑, *STAT↓, *NF-kB↓, *neuroG↑, *memory↑, ROS↑, NLRP3↑, CIP2A↓, Akt↓, STAT3↑, VEGFR2/KDR/Flk1↓, DNMTs↓, MAPK↓, YAP/TEAD↓, PI3K↓, Wnt↓, NOTCH↓, TumCCA↑, TumCG↓, TumCP↓, FAK↑, MMP9↓, TumAuto↑, toxicity↝, BioAv↓, Half-Life↝, BioAv↑, selectivity∅,
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
6705- DFC,    Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
- Review, Var, NA
*Inflam↓, *Pain↓, *COX1↓, *COX2/PTGS2↓, *toxicity↝, *BioAv↑, *AntiAg↑, *neuroP↑, ROS↑, p73↑, Myc↓, lactateProd↓, TumCCA↑, PI3K↓, Akt↓, NF-kB↓, SOD2↓, *neuroP↑,
6789- EGCG,    Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?
- Review, Var, NA
BioAv↓, Half-Life↝, Half-Life↝, BioAv↝, *BioAv↑, *BioAv↓, *BioAv↑, *BioAv↑, *Dose↝, *toxicity↝,
6788- EGCG,    A systematic review and meta-analysis of the effects of green tea extracts and polyphenols in female hormone-dependent cancers for benefit-risk evaluation
- Review, BC, NA - Review, Ovarian, NA
TumVol↓, TumW↓, *toxicity↝,
6785- EGCG,    Epigallocatechin-3-gallate at the nanoscale: a new strategy for cancer treatment
- Review, Var, NA
AntiCan↑, BioAv↓, CompStab↑, EPR↑, TumCG↓, *Half-Life↝, BioAv↑, eff↑, eff↑, eff↑, NF-kB↓, ROS↑, ChemoSen↑, *toxicity↝,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *Synergy↑, *BioAv↑, Synergy↑, ChemoSen↑, *toxicity↝,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6815- EMD,    NMR-based Metabolomic Techniques Identify the Toxicity of Emodin in HepG2 Cells
- in-vitro, Liver, HepG2
AntiCan↑, *hepatoP↑, *Inflam↓, *antiOx↑, *AntiBio↑, *toxicity↝, tumCV↓, TumCP↓, Apoptosis↑, ALAT↓, glucose↓, GSH↓, ATP↓,
6429- ESTr,  FEO,    Can Estragole in Fennel Seed Decoctions Really Be Considered a Danger for Human Health? A Fennel Safety Update
- Review, Nor, NA
*toxicity↝,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *CompStab↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1 / PDPK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6323- Eug,    Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects
- Review, Var, NA - Review, Arthritis, NA
*AntiCan↑, *AntiDiabetic↑, *cardioP↑, *toxicity↝, *GutMicro↑, *neuroP↑, *BioAv⇅, *BioAv↝, *antiOx↑, *Inflam↑, *AntiArt↑, *TNF-α↓, *IL6↓, *IL10↓, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TAC↑, TumCMig↓, TumCI↓, Akt↑, FOXO3↑, Casp3↑, Casp9↑, P21↑, angioG↓, TumCI↓, Apoptosis↑, NF-kB↓, Synergy↑, Synergy↑, ChemoSen↑, NA↑, Casp3↑, Casp9↑, *AntiDiabetic↑, *glucose↓, *ROS↓, *Inflam↓, *MDA↓, *GSH↑, *BioAv↑,
6952- FA,    Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop
- Review, AD, NA
*other↝, *other↝, *Dose↑, *Dose↝, *Risk↓, *cognitive↑, *toxicity↝,
6430- FEO,    Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety
- Review, Nor, NA
*Dose↝, *Bacteria↓, *hepatoP↑, *antiOx↑, *AntiThr↑, *AntiDiabetic↑, *toxicity↝,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
4016- FulvicA,    Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
- Review, AD, NA
*tau↓, *AntiAge↑, *Strength↑, *Dose↝, *BioAv↑, *antiOx↑, *memory↑, *Inflam↓, *cognitive↑, *neuroP↑, *toxicity↝, *toxicity↑,
7204- GAs,    The Pharmacology and Toxicology of Ginkgolic Acids: Secondary Metabolites from Ginkgo biloba
- Review, Nor, NA
AntiTum↑, SUMO↓, antiNeop↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *toxicity↑, *ROS↑, *toxicity↝,
7213- GAs,    Anti-Cancer Properties of Ginkgolic Acids in Human Nasopharyngeal Carcinoma CNE-2Z Cells via Inhibition of Heat Shock Protein 90
- vitro+vivo, NPC, CNE2 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Lung, H1975
ATPase↓, HSP90↓, TumCP↓, *toxicity↝, MMP2↓, MMP9↓, HER2/EBBR2↓, c-Raf↓, Akt↓, Bcl-2↓, other↝,
7114- GeS,    A phase II study of spirogermanium in advanced human malignancy
- Human, Var, NA
*toxicity↝,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,

Showing Research Papers: 1 to 50 of 81
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 81

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 2,   Fenton↑, 2,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 5,   H2O2↑, 1,   HNE↑, 1,   HO-1↓, 1,   HO-1↑, 1,   Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↓, 1,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 1,   ROS↓, 3,   ROS↑, 19,   ROS⇅, 1,   mt-ROS↑, 2,   SOD↓, 1,   SOD↑, 1,   SOD2↓, 1,   Thiols↓, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   compI↓, 1,   compIV↓, 1,   ETC↓, 1,   mtDam↑, 2,   OCR↓, 1,   OXPHOS↓, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 1,   ATP↓, 4,   glucose↓, 1,   Glycolysis↓, 2,   Glycolysis↝, 1,   HK2↓, 1,   lactateProd↓, 1,   PDK1 / PDPK1↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 15,   BAD↓, 1,   BAX↑, 2,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Casp↑, 3,   Casp3↑, 6,   cl‑Casp3↑, 2,   cl‑Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 6,   cl‑Casp9↑, 1,   CellShr↑, 1,   Cupro↑, 1,   Cyt‑c↑, 5,   FADD↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   iNOS↓, 2,   MDM2↑, 1,   MOMP↑, 2,   p38↓, 1,   p38↑, 1,   Paraptosis↑, 1,   survivin↓, 3,   TNFR 1↑, 1,   TumCD↑, 5,   XIAP↓, 1,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   Akt↑, 1,   p‑Akt↓, 2,   CIP2A↓, 1,   EGFR↓, 3,   ERK↓, 1,   ERK↑, 1,   HER2/EBBR2↓, 4,   JAK2↓, 1,   JNK↑, 1,   MAPK↓, 3,   MAPK↑, 1,   mTOR↓, 7,   PI3K↓, 8,   PTEN↑, 1,   c-Raf↓, 1,   STAT3↓, 4,   STAT3↑, 1,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMTs↓, 1,   FOXO3↑, 1,   FOXO3↝, 1,   HDAC↓, 1,   miR-25-5p↓, 1,   miR-34a↓, 1,   Myc↓, 1,   OCT4↓, 2,   other↑, 1,   other↝, 5,   SD↑, 1,   SOX2↓, 1,   SUMO↓, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 3,   HSP90↓, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG7↑, 1,   Beclin-1/ATG6↑, 3,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 10,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   hTERT/TERT↓, 1,   P53↑, 4,   p73↑, 1,   PARP↑, 2,   cl‑PARP↑, 2,   PCNA↓, 3,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 2,   CDKN1C/p57↑, 1,   ChrCon↑, 1,   cycD1/CCND1↓, 3,   E2Fs↓, 1,   Ki-67↓, 4,   P21↑, 2,   p27/CDKN1B↓, 1,   pRB↓, 1,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 3,   CSCsMark↓, 1,   IGF-1↓, 1,   Ki-67↓, 4,   NOTCH↓, 1,   NOTCH1↓, 2,   OGFr↑, 1,   STAT1↓, 1,   TumCG↓, 7,   TumCP↓, 9,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↑, 1,   ATPase↓, 1,   Ca+2↑, 1,   COL1↓, 1,   E-cadherin↑, 2,   EMT↓, 6,   EpCAM↓, 1,   FAK↑, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   MMP2↓, 6,   MMP9↓, 8,   MMPs↓, 2,   RECK↑, 1,   Slug↓, 2,   Smad1↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TRIB3↑, 1,   TumCI↓, 8,   TumCMig↓, 7,   TumMeta↓, 4,   TumMeta↑, 2,   Twist↓, 2,   Vim↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   angioG↑, 1,   CD31/PECAM-1↓, 1,   Hif1a↓, 3,   NO↑, 1,   VCAM-1↓, 2,   VEGF↓, 5,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   EPR↑, 1,   MMP↓, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   COX2/PTGS2↓, 6,   DR4↑, 1,   FOXP3↑, 1,   ICAM-1↓, 2,   IL1β↓, 3,   IL6↓, 3,   Imm↑, 3,   Inflam↓, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 6,   NF-kB↑, 1,   NLRP3↑, 1,   PD-L1↓, 1,   PGE2↓, 1,   PGE2↑, 1,   Th1 response↑, 1,   Th17↑, 1,   TNF-α↓, 3,   TRADD↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER-α36↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 3,   BioAv↝, 3,   ChemoSen↑, 18,   CompStab↑, 1,   CYP1A1↑, 2,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 8,   Dose∅, 2,   eff↓, 1,   eff↑, 18,   eff↝, 2,   Half-Life↝, 3,   P-gp/ABCB1↓, 2,   P450↓, 2,   RadioS↑, 5,   selectivity↑, 13,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 11,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   EGFR↓, 3,   HER2/EBBR2↓, 4,   hTERT/TERT↓, 1,   IL6↓, 3,   Myc↓, 1,   PD-L1↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 10,   antiNeop↑, 2,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 9,   chemoPv↑, 1,   CR↑, 1,   hepatoP↑, 2,   neuroP↑, 1,   OS↑, 4,   OS∅, 1,   PFS∅, 1,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 5,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 4,   TumW↓, 1,   Weight↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 6,  
Total Targets: 271

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 16,   ARE↑, 1,   Catalase↑, 7,   GPx↑, 6,   GPx1↑, 1,   GPx4↓, 1,   GSH↓, 1,   GSH↑, 5,   GSTs↑, 4,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 2,   Iron↝, 1,   lipid-P↓, 4,   lipid-P↑, 1,   MDA↓, 5,   MDA↑, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2?, 1,   NRF2↓, 1,   NRF2↑, 5,   ROS↓, 19,   ROS↑, 4,   ROS⇅, 2,   selenoP↑, 2,   SOD↓, 2,   SOD↑, 9,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 2,   xCT/SLC7A11↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 4,   ALAT↑, 1,   AMPK↓, 1,   AMPK↑, 3,   ATP↓, 1,   ATP↑, 1,   CRM↑, 1,   CYP51/14LDM↑, 1,   glucose↓, 4,   glyC↓, 1,   GSK‐3β↓, 1,   LDL↓, 3,   lipidLev↓, 1,   NAD↓, 1,   SCFAs↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↓, 1,   Casp3↓, 2,   Casp9↓, 1,   Cyt‑c↓, 1,   Ferroptosis↑, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   CREB↑, 1,   IKKα↓, 1,   JAK2↑, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   mTOR↓, 2,   PI3K↓, 1,   PTEN↑, 1,   STAT↓, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↓, 1,   other↝, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   GRP78/BiP↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 1,   P53↓, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

GADD34↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 6,   AP-1↓, 1,   Cartilage↑, 1,   MLC2/MYL9↝, 1,   TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   NO↓, 3,   VCAM-1↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   MMP↑, 1,   OCLN↝, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD40↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 4,   HMGB1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL10↓, 3,   IL17↓, 2,   IL1β↓, 1,   IL6↓, 6,   IL8↓, 1,   Imm↓, 1,   Imm↑, 2,   Inflam↓, 20,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   MyD88↓, 1,   NeuroI↓, 1,   NF-kB↓, 8,   NK cell↑, 1,   NLRP3↓, 3,   NLRP3↑, 2,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 9,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   BDNF↓, 1,   BDNF↑, 1,   DHCR7↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 2,   tau↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 21,   BioAv⇅, 1,   BioAv↝, 7,   BioEnh↑, 1,   CompStab↑, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 20,   eff↑, 8,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 8,   P-gp/ABCB1↓, 1,   P450↓, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALAT↑, 1,   ALP↓, 1,   AST↓, 3,   AST↑, 1,   BloodF↑, 2,   BP↓, 2,   BP↝, 1,   creat↓, 1,   creat↑, 1,   CRP↓, 2,   hs-CRP↓, 1,   IL6↓, 6,   TC↓, 1,   TG/TAG↓, 1,   Urea↓, 1,   Urea↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 3,   antiAll↑, 3,   AntiArt↑, 4,   AntiCan↑, 6,   AntiDiabetic↑, 8,   AntiTum↑, 1,   cardioP↑, 8,   chemoP↑, 1,   cognitive↑, 5,   cough?, 1,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 12,   memory↑, 4,   Mucositis↓, 1,   neuroP↑, 16,   Obesity↓, 3,   Pain↓, 3,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 2,   Sleep↑, 2,   SoreThr?, 1,   Strength↑, 1,   Stroke↓, 1,   toxicity↓, 5,   toxicity↑, 4,   toxicity↝, 87,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 6,   AntiP↑, 1,   AntiViral↑, 5,   Bacteria↓, 10,   GutMicro↑, 7,   insect↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 1,   Ingr↝, 6,  
Total Targets: 215

Scientific Paper Hit Count for: toxicity, toxicity
9 5-Hydroxytryptophan
9 Silver-NanoParticles
4 EGCG (Epigallocatechin Gallate)
3 Phenethyl isothiocyanate
3 Emodin
3 Eugenol
3 Licorice
3 Matrine
3 Metformin
2 Benzyl isothiocyanate
2 Chrysin
2 Copper and Cu NanoParticles
2 Spirulina(Arthrospira/Limnospira)
2 Fennel Oil/Foeniculum vulgare
2 Ginkgolic acids
1 Auranofin
1 Vitamin C (Ascorbic Acid)
1 Gold NanoParticles
1 Aloe anthraquinones
1 Allyl isothiocyanate
1 borneol
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Cisplatin
1 Coenzyme Q10
1 chemodynamic therapy
1 Cucurbitacin
1 Chlorella (Chlorella vulgaris)
1 Diclofenac
1 Estragole
1 Folic Acid, Vit B9
1 Flaxseed/Linseed
1 Shilajit/Fulvic Acid
1 Germanium-Spirogermanium
1 Ginkgetin
1 Honokiol
1 Hyperthermia
1 Radiotherapy/Radiation
1 Inositol
1 Laetrile B17 Amygdalin
1 low dose naltrexone
1 Lemongrass Extract/Citral
1 Morin
1 Mucuna pruriens/Velvet Bean
1 Nasturtium, Indian Cress
1 Phenylbutyrate
1 Rosmarinic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 salinomycin
1 Sulfasalazine
1 Selenium
1 Selenium NanoParticles
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1025  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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