Half-Life Cancer Research Results

Half-Life, Half-Life: Click to Expand ⟱
Source:
Type:
For many drugs, the half-life is the time it takes for half of the drug’s active substance to be eliminated from the bloodstream.
In medicine, knowing a drug’s half-life helps in designing treatment regimens that reduce adverse effects.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
6469- 1,8-Cin,    Pharmacokinetic Studies of the Fragrance Compound 1,8-Cineol in Humans during Inhalation
- Human, Nor, NA
*BioAv↑, *Half-Life↝,
5291- 5-HTP,    Kinetics of l-5-hydroxytryptophan in healthy subjects
- in-vivo, Nor, NA
*Half-Life↝, *BioAv↑,
5456- AF,    Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent
- Trial, Nor, NA
*Dose?, *Half-Life↝, *Dose↑, *toxicity↝, *Bacteria↓, *Dose↑,
4600- AgNPs,    Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model
- in-vivo, Nor, NA
*Half-Life↝, *toxicity↓, *Dose↑, *other↝, *eff↝, *BioAv↓,
5355- AL,    Mini-review: The health benefits and applications of allicin
- Review, Var, NA
*BioAv↑, *cardioP↑, *hepatoP↑, *RenoP↑, *Half-Life↝, *BioAv↓, *neuroP↑, *cognitive↑, *ROS↓, *lipid-P↓, *DNArepair↑, *ChemoSen↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
5322- ALC,    Comparison of pharmacokinetics of L-carnitine, Acetyl-L-carnitine and Propionyl-Lcarnitine after single oral administration of L-carnitine in healthy volunteers
- Human, Nor, NA
*Half-Life↝,
1542- Api,    Bioavailability of Apigenin from Apiin-Rich Parsley in Humans
- Human, Nor, NA
*BioAv↝, *Half-Life↝,
2569- ART/DHA,    A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction
- Human, Nor, NA
*Half-Life↝, BioAv↝, *Half-Life↓, BioAv↑, *Dose↝,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, Synergy↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, ChemoSen↑,
5423- ASTX,    Pharmacokinetic Profile of Astaxanthin Nanoemulsion Using HPLC (High-Performance Liquid Chromatography) With Oral Routes
- in-vivo, Nor, NA
*BioAv↓, *antiOx↑, *BioAv↑, *Half-Life↝,
5445- ATV,    Atorvastatin
- Review, Nor, NA
*cardioP↑, *LDL↓, *HMG-CoA↓, *Half-Life↝, *BioAv↓, *Dose↝,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
5500- Ba,    Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single‐center, randomized, double‐blind, placebo‐controlled multiple‐ascending‐dose study
- Trial, Nor, NA
*toxicity↓, *BioAv↑, *Half-Life↝, *Dose↝,
2671- BBR,    Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action
- in-vivo, Diabetic, NA
*BioAv↓, *Half-Life↝, *OCR↓, *AMPK↑,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
5676- BML,    Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake
- in-vivo, Nor, NA
*Half-Life↝, *Dose↝, *Dose↝,
5654- BNL,    Pharmacokinetics of natural borneol after oral administration in mice brain and its effect on excitation ratio
- in-vivo, Nor, NA
*BioAv↑, *Half-Life↝, other↝,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp/ABCB1↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5672- Bor,    A comparative review of the pharmacokinetics of boric acid in rodents and humans
- in-vivo, Nor, NA
*Half-Life↝,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3512- Bor,    Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake
- in-vitro, Pca, DU145
TumCP↓, eIF2α↑, ATF4↑, ATF6↑, GADD34↑, CHOP/DDIT3↓, GRP78/BiP↑, GRP94↑, Risk↓, *BMD↑, Ca+2↓, *Half-Life↝, IRE1∅, chemoP↑,
4624- Bor,  VitD3,    Boron as a Medicinal Ingredient in Oral Natural Health Products
- Review, Pca, NA
*Half-Life↝, *eff↑, PSA↓, TumVol↓, IGF-1↓, *memory↓, *motorD↓,
5811- CBC,    The Potential of Cannabichromene (CBC) as a Therapeutic Agent
- Review, Var, NA
*eff?, *Half-Life↝, *Inflam↓,
6636- Cen,    Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial
- Trial, AD, NA
*cognitive↑, *NRF2↑, *Dose↝, *memory↑, *ROS↓, *mitResp↑, *neuroP↑, *Half-Life↝, *Half-Life↝, *Half-Life↝,
6029- CGA,    Pharmacokinetics of chlorogenic acids absorbed in human plasma and their metabolites following oral ingestion of coffee drink
- Trial, Nor, NA
*Dose↝, *BioAv↑, *Half-Life↝,
6194- Cuc,    Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats
- in-vivo, Nor, NA
*BioAv↓, *Half-Life↝, *AST∅, *ALAT∅, *RenoP↝, *Half-Life↝,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2/PTGS2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *Synergy↑,
8844- DIM,  I3C,    Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Imm↝, *BioAv↝, *Half-Life↝, *PKCδ↓, *TGF-β1↓, *PPARγ↓, *CEBPA↓, *FABP4↓, *AMPKα↑, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, *Akt↑, *Inflam↓, *TMAO↓, *SREBF2⇅, *memfluid↑, *GutMicro↑, *Obesity↓, *hepatoP↑, *neuroP↑, *AntiAg↓, *Stroke↓, *AntiAg↓, *HDAC↑, *IL1β↓, *IL6↓, *iNOS↓, *IL4↑, *IL10↑, *Synergy↑, *compI↑, *ROS↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *cognitive↑, *Analgesic↑, *Pain↓, *BDNF↑, *TrkB↑, *Akt↑, *antiOx↑, *Apoptosis↓, *cardioP↑, *chemoP↑, *AntiThr↑, *uPA↑, *NRF2↑, *ARE↑, *HO-1↑, *Bacteria↓, *TOP1↓, *AntiFungal↑, *AntiViral↑, *radioP↑, *Synergy↑, *hepatoP↑, *Diar↓, *ChemoSen↑, *Telomerase↓, *BioAv↓,
6604- Ech,    Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion
- Human, Nor, NA
*BioAv↑, *Half-Life↝, *Dose↝, Dose?,
7222- EGb 761,    Ginkgo biloba extract EGb 761® in the symptomatic treatment of mild-to-moderate dementia: a profile of its use
- Review, AD, NA
*cognitive↑, *toxicity↓, *Dose↝, *BioAv↑, *Half-Life↑, *neuroP↑, *Half-Life↝, *Dose↝, *other↝, *eff↑,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
6785- EGCG,    Epigallocatechin-3-gallate at the nanoscale: a new strategy for cancer treatment
- Review, Var, NA
AntiCan↑, BioAv↓, CompStab↑, EPR↑, TumCG↓, *Half-Life↝, BioAv↑, eff↑, eff↑, eff↑, NF-kB↓, ROS↑, ChemoSen↑, *toxicity↝,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
6982- Form,    Formononetin: A Review of Its Anticancer Potentials and Mechanisms
- Review, Var, NA
AntiTum↑, Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, TumCCA↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycD1/CCND1↓, TumCP↓, VEGF↓, FGF↓, MMP2↓, MMP9↓, Synergy↑, ChemoSen↑, chemoPv↑, p‑Akt↓, p‑STAT3↑, TumCMig↓, TumCI↓, TIMP1↑, TIMP2↑, PI3K↓, Akt↓, Dose↝, TumCG↓, TumW↓, TumVol↓, angioG↓, Casp3↑, Casp9↑, cl‑PARP↑, DNArepair↓, MMP↓, BAX↑, Bcl-2↓, DR5↑, ROS↑, eff↓, p‑ERK↓, PTEN↑, Hif1a↓, eff↑, Synergy↑, ChemoSen↑, HDAC↓, *BioAv↑, *Half-Life↝, *BioAv↝, *BioAv↑, *BioAv↑, *eff↑,
6992- Form,    Formononetin: pharmacological properties and therapeutic potential
- Review, Nor, NA
*BMD↑, *BioAv↑, *Half-Life↝, *BioAv↑,
7026- Fuc,    Fucoidan
- Review, AD, NA
*Inflam↓, *ROS↓, *BioAv↓, *GutMicro↑, *neuroP↑, *glucose↝, *AntiThr↑, *chemoP↑, *Half-Life↝, *BBB∅, *AntiAge↑, Risk↑,
7069- GABA,    United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
- Review, Nor, NA
*toxicity↓, *BP↓, *AntiDiabetic↑, *AntiCan↑, *antiOx↑, *Inflam↓, *AntiBio↑, *other↝, *cognitive↑, *GH↑, *Sleep↑, *BioAv↑, *Half-Life↝, *BBB↓, *Synergy↑,
7128- Ge-132,    Pharmacokinetics of germanium after po beta-carboxyethylgermanium sesquioxide in 24 Chinese volunteers
- Trial, Nor, NA
*Half-Life↝,
7123- GEO2,    Kinetics of germanium dioxide in rats
- in-vivo, Nor, NA
*Half-Life↝,
7135- GI,    Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans
- Trial, Nor, NA
*Dose↝, *Half-Life↝, *antiOx↑, *Inflam↓, *AntiTum↑, *Half-Life↓,
7280- Gins,    Pharmacokinetics of ginsenoside Rb1 and its metabolite compound K after oral administration of Korean Red Ginseng extract
- Trial, Nor, NA
*BioAv↑, *Half-Life↝, *eff↝,
7506- HCAs,    A Systematic Review and Comprehensive Evaluation of Human Intervention Studies to Unravel the Bioavailability of Hydroxycinnamic Acids
- Review, Nor, NA
*other↝, *BioAv↝, *Half-Life↝, *other↝, *Dose↝, *BioAv↝,
7349- HibSad,    Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract
- Trial, Nor, NA
*Dose↝, *Half-Life↓, *Half-Life↝, *BioAv↓, *antiOx↑, *BioAv↓,
7461- HNK,    Honokiol: a potent chemotherapy candidate for human colorectal carcinoma
- vitro+vivo, CRC, RKO
Apoptosis↑, Casp↑, Dose↝, OS↑, *Inflam↓, *AntiThr↑, *antiOx↑, *Half-Life↝, TumCG↓,
7462- HNK,    Neuroprotective effects of honokiol: from chemistry to medicine
- Study, AD, NA
*ATR↑, *neuroP↑, *antiOx↑, *Inflam↓, *Half-Life↝, *ROS↓, *Ca+2↓, *GABA↓, *COX2/PTGS2↓, *memory↑,
7374- HOO,    Exploring Ozonated Vegetable Oils as Antimicrobial and Functional Agents in Food Systems: A Systematic Narrative Review
- Review, Nor, NA
*AntiBio↑, *CompStab↝, *Half-Life↝, *eff↑, *Phen↑, *antiOx↑, eff↝, eff↝,
7524- HT,    The Pharmaceutical Formulation Plays a Pivotal Role in Hydroxytyrosol Pharmacokinetics
- Trial, Nor, NA
*Dose↝, *BioAv↝, *Half-Life↝, *toxicity↓, *BioAv↝, *BioAv↝,
7526- HT,    Hydroxytyrosol in functional hydroxytyrosol-enriched biscuits is highly bioavailable and decreases oxidised low density lipoprotein levels in humans
- Trial, Nor, NA
*Half-Life↝, *BioAv↑, *Dose↝, *BioAv↝,

Showing Research Papers: 1 to 50 of 89
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 89

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Catalase↑, 1,   GPx↓, 1,   GSH↓, 5,   GSR↓, 1,   GSTs↓, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 2,   ROS↓, 3,   ROS↑, 13,   ROS⇅, 3,   i-ROS↑, 1,   SOD↓, 2,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MFN2↑, 1,   mtDam↑, 1,   OCR↓, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↑, 1,   ATP↓, 2,   FASN↓, 1,   GlutMet↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 1,   PKM2↓, 1,   SIRT1↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis↑, 12,   ASC↓, 1,   Bak↑, 1,   BAX↑, 8,   Bcl-2↓, 11,   Bcl-2↑, 1,   Bcl-xL↓, 2,   Casp↑, 3,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 11,   cl‑Casp3⇅, 1,   Casp7↑, 2,   Casp8↑, 5,   Casp9↑, 8,   CellShr↑, 1,   Cyt‑c↑, 8,   DR5↑, 2,   FADD↑, 1,   Fas↑, 3,   FasL↑, 1,   IAP1↓, 1,   IAP2/BIRC3↑, 1,   Mcl-1↓, 1,   p‑MDM2↓, 1,   MOMP↑, 2,   Necroptosis↑, 1,   necrosis↑, 1,   p38↓, 1,   p38↑, 3,   p‑p38↑, 1,   survivin↓, 5,   TNFR 1↑, 1,   XIAP↓, 3,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 9,   p‑Akt↓, 2,   EGFR↓, 1,   EGFR↑, 1,   ERK↓, 3,   p‑ERK↓, 2,   HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   IKKα↓, 1,   IκB↓, 1,   JAK2↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 2,   MAPK↝, 1,   mTOR↓, 8,   mTOR↝, 1,   PI3K↓, 7,   p‑PI3K↓, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 4,   p‑Src↓, 1,   STAT3↓, 5,   p‑STAT3↑, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   p‑cJun↑, 1,   cMyc↓, 1,   DNMTs↓, 1,   FOXO3↑, 1,   H3↓, 1,   H4↓, 1,   HDAC↓, 4,   HDAC3↓, 1,   miR-34a↑, 1,   OCT4↓, 1,   other?, 1,   other↝, 2,   SOX2↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   IRE1∅, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   DNAdam↑, 4,   DNArepair↓, 1,   P53↑, 5,   PARP↑, 2,   cl‑PARP↑, 6,   PCNA↓, 3,   Telomerase↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CHK1↓, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 4,   GADD34↑, 1,   Ki-67↓, 1,   P21↑, 2,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 1,   pRB↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↓, 1,   cFos↑, 1,   CSCs↓, 1,   FGF↓, 1,   IGF-1?, 1,   IGF-1↓, 1,   Ki-67↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   TumCG↓, 3,   TumCP↓, 9,  

Migration(tgid=13) ⓘ

AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 2,   Cdc42↓, 1,   COL1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 1,   EMT↓, 6,   FAK↓, 1,   p‑FAK↓, 1,   Fibronectin↓, 1,   ITGB1↓, 2,   ITGB6↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP2↓, 5,   MMP9↓, 5,   MMPs↓, 3,   MUC4↓, 1,   N-cadherin↓, 2,   Rac1↓, 2,   Rho↓, 1,   Slug↓, 1,   Snail↓, 2,   TIMP1↑, 2,   TIMP2↑, 1,   TumCI↓, 4,   TumCMig↓, 5,   TumMeta↓, 2,   Twist↓, 3,   Tyro3↓, 1,   uPA↓, 1,   Vim↓, 1,   Vim↑, 1,   Zeb1↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   angioG↑, 1,   Hif1a↓, 4,   VCAM-1↓, 1,   VEGF↓, 8,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   EPR↑, 1,   MMP↓, 7,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   DR4↑, 1,   ICAM-1↓, 2,   IL2↑, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 2,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   p‑NF-kB↑, 1,   NLRP3↓, 1,   p‑p65↓, 2,   PD-1↓, 1,   PSA↓, 2,   Th1 response↑, 1,   Th17↑, 1,   TNF-α↓, 1,   TRADD↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   ChemoSen↑, 13,   CompStab↑, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↝, 8,   eff↓, 1,   eff↑, 7,   eff↝, 2,   P-gp/ABCB1↓, 1,   P450↓, 1,   RadioS↑, 4,   selectivity↑, 4,   Synergy?, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   CEA↓, 1,   EGFR↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 3,   LDH↓, 1,   LDH↝, 1,   NSE↓, 1,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiTum↑, 2,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 8,   chemoPv↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   radioP?, 1,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 4,   Risk↑, 1,   toxicity↝, 1,   TumVol↓, 2,   TumW↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 288

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 25,   ARE↑, 2,   Bil↑, 1,   Catalase↑, 9,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 8,   GPx1↑, 1,   GSH↑, 7,   GSTs↓, 1,   GSTs↑, 3,   H2O2↓, 2,   HDL↑, 1,   HO-1↑, 6,   Keap1↓, 1,   lipid-P↓, 11,   mt-lipid-P↓, 1,   MDA↓, 8,   MPO↓, 3,   NADH↓, 1,   NQO1↑, 3,   NRF2?, 1,   NRF2↑, 11,   RNS↓, 2,   ROS↓, 32,   SOD↑, 14,   SOD1↑, 2,   SOD2↑, 2,   TAC↑, 1,   TBARS↓, 1,   TOS↓, 1,   TrxR↑, 1,   uricA↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,   IronCh↝, 1,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   Insulin↓, 1,   mitResp↑, 1,   OCR↓, 1,   PGC-1α↑, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ALAT↓, 3,   ALAT↑, 1,   ALAT∅, 1,   AMPK↑, 8,   ATP↑, 2,   CRM↑, 1,   FABP4↓, 1,   glucose↓, 1,   glucose↝, 2,   glyC↓, 1,   GSK‐3β↓, 4,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 2,   NADH:NAD↑, 1,   NADPH↑, 1,   SIRT1↑, 2,   SREBF2⇅, 1,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 3,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 5,   Casp9↓, 1,   Cyt‑c∅, 1,   iNOS↓, 7,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 3,   AMPKα↑, 1,   CREB↑, 1,   p‑ERK↑, 1,   IGF-1R↓, 1,   JAK↓, 1,   JAK2↓, 1,   JAK2↑, 1,   JNK↓, 1,   p‑MAPK↓, 1,   mTOR↓, 2,   P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   STAT↓, 1,   STAT3↓, 1,   STAT3↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   FOXO↑, 1,   HDAC↑, 1,   other↓, 2,   other↑, 5,   other↝, 8,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   MitoP↑, 1,   PARK2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATR↑, 1,   DNArepair↑, 1,   P53↓, 1,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   GH↑, 1,   neuroG↑, 2,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 2,   AP-1↓, 2,   Ca+2↓, 2,   Cartilage↑, 1,   COL1↑, 1,   MMP13↓, 1,   MMP2↓, 1,   MMP9↓, 2,   N-cadherin↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TGF-β1↓, 1,   uPA↑, 1,   α-SMA↓, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↑, 1,   NO↓, 3,   VCAM-1↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 3,   BBB↑, 10,   BBB∅, 1,   GastroP↑, 1,   memfluid↑, 1,   MMP↑, 2,   TRPA1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 12,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL10↑, 2,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 12,   IL4↑, 1,   IL6↓, 12,   IL8↓, 4,   Imm↑, 2,   Imm↝, 1,   Inflam↓, 30,   MCP1/CCL2↓, 2,   NeuroI↓, 1,   NF-kB↓, 9,   NF-kB↑, 1,   NLRP3↓, 3,   p65↓, 1,   PGE2↓, 4,   RANTES↓, 1,   TLR4↓, 2,   TNF-α↓, 16,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 3,   BChE↓, 2,   BDNF↑, 3,   ChAT↑, 2,   GABA↓, 1,   MAOA↓, 1,   MAOB↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 8,   Aβ42↓, 1,   BACE/β-secretase↓, 4,   tau↓, 1,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 2,   PPARγ↑, 2,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 20,   BioAv↑, 39,   BioAv↝, 28,   BioEnh↑, 1,   ChemoSen↑, 2,   CompStab↝, 1,   CYP3A4↓, 1,   Dose?, 2,   Dose↑, 4,   Dose↝, 29,   eff?, 1,   eff↑, 13,   eff↝, 2,   GSTA1↑, 1,   Half-Life↓, 3,   Half-Life↑, 3,   Half-Life↝, 97,   P-gp/ABCB1↓, 1,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALAT↑, 1,   ALAT∅, 1,   AST↓, 3,   AST↑, 1,   AST∅, 1,   Bil↑, 1,   BMD↑, 3,   BP↓, 4,   creat↓, 2,   IL6↓, 12,   LDH↓, 2,   NOS2↓, 1,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 1,   antiAll↑, 3,   AntiArt↑, 1,   AntiCan↑, 5,   AntiDiabetic↑, 4,   AntiTum↑, 1,   cardioP↑, 12,   chemoP↑, 2,   chemoPv↑, 2,   cognitive↑, 14,   hepatoP↓, 1,   hepatoP↑, 14,   memory↓, 1,   memory↑, 10,   Mood↑, 1,   motorD↓, 1,   motorD↑, 2,   neuroP↑, 24,   Obesity↓, 3,   Pain↓, 2,   radioP↑, 2,   RenoP↑, 2,   RenoP↝, 1,   Risk↓, 1,   Sleep↑, 1,   Strength↑, 1,   Stroke↓, 1,   toxicity↓, 11,   toxicity↝, 8,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 2,   AntiViral↑, 3,   Bacteria↓, 5,   Diar↓, 1,   GutMicro↑, 7,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,   Phen↑, 1,  
Total Targets: 262

Scientific Paper Hit Count for: Half-Life, Half-Life
4 Boron
3 Mangiferin
2 1,8-Cineole
2 Allicin (mainly Garlic)
2 Baicalein
2 Berberine
2 borneol
2 EGCG (Epigallocatechin Gallate)
2 Formononetin
2 Honokiol
2 HydroxyTyrosol
2 Phenethyl isothiocyanate
2 Isovitexin
2 SDG/lignans
2 Luteolin
2 Metformin
2 Sulforaphane (mainly Broccoli)
2 Thymoquinone
1 5-Hydroxytryptophan
1 Auranofin
1 Silver-NanoParticles
1 Acetyl-l-carnitine
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Atorvastatin
1 Bromelain
1 Vitamin D3
1 Cannabichromene
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Cucurbitacin
1 Curcumin
1 Diindolylmethane
1 Indole-3-carbinol
1 Echinacea
1 Ginkgo biloba-EGb 761
1 Ferulic acid
1 Fucoidan
1 Gamma-aminobutyric acid
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Germanium inorganic
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 High-Ozonide Oil
1 Huperzine A/Huperzia serrata
1 Inositol
1 Isoliquiritigenin
1 Isorhamnetin
1 isoorientin
1 isoquercitrin
1 Isothiocyanates
1 Vitexin
1 Lycopene
1 Radiotherapy/Radiation
1 Matrine
1 Methyl salicylate / Sweet Birch oil
1 Moringin
1 Methylsulfonylmethane
1 Mistletoe/Viscum album Extracts
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Phosphatidylserine
1 Resveratrol
1 Rosmarinic acid
1 Broccoli
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Spirulina(Arthrospira/Limnospira)
1 Thyme
1 Thymol-Thymus vulgaris
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1109  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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