BioAv Cancer Research Results

BioAv, bioavailability: Click to Expand ⟱
Source:
Type: measurement
Bioavailability (usually in %) absorbed by the body.
Scientific Papers found: Click to Expand⟱
9261- Acai, EO,    Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers
- Study, Nor, NA
*Dose?, *BioAv↝, *eff↑,
5457- AF,    Clinical pharmacokinetics of oral and injectable gold compounds
- Human, Nor, NA
*BioAv↝, *Dose↝, *Half-Life↑, *BioAv↝, *other↝,
4598- AgNPs,    In vivo human time-exposure study of orally dosed commercial silver nanoparticles
- in-vivo, Nor, NA
*toxicity∅, *Dose↝, *Dose↝, *BioAv↝, *BioAv↝, *H2O2∅, *IL8∅, *IL1α∅, *IL1β∅, *MCP1/CCL2∅, *NQO1∅, *BioAv↓,
4595- AgNPs,    ORAL DELIVERY OF SILVER NANOPARTICLES – A REVIEW
- Review, Nor, NA
*BioAv↝,
1916- AL,    Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods
- Review, Nor, NA
*BioAv↝, *eff↓, *BioAv↝, *BioAv↝, *eff↑, *Half-Life∅, *eff↑, *eff↑, *Dose∅, *eff↑,
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27/CDKN1B↑, PDH↑, Glycolysis↓, ROS↑, *Synergy↑, *memory↑, *motorD↑, *GutMicro↑,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3551- ALA,    Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus
- in-vivo, AD, NA
*cognitive↑, *Apoptosis↓, *Inflam↓, *antiOx↑, *BioAv↝, *neuroP↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, CompStab↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
1542- Api,    Bioavailability of Apigenin from Apiin-Rich Parsley in Humans
- Human, Nor, NA
*BioAv↝, *Half-Life↝,
5412- ASA,    Clinical Pharmacology of Aspirin
- Review, Nor, NA
*COX1↓, *COX2/PTGS2↓, *cardioP↑, *BioAv↑, *BioAv↝, *Half-Life↓, Risk↓, *other↑, *AntiAg↑,
5393- Ash,    Studies on oral bioavailability and first-pass metabolism of withaferin A in rats using LC-MS/MS and Q-TRAP
- in-vivo, Nor, NA
*BioAv↝, *other↝, *Half-Life↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, Synergy↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, ChemoSen↑,
4815- ASTX,    The Promising Effects of Astaxanthin on Lung Diseases
- Review, Var, NA
Dose↑, *BioAv↝, *BioAv↝, *antiOx↑, *NRF2↑, *ERK↓, *antiAll↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
5504- Ba,    Comparative Pharmacokinetics of Baicalin, Wogonoside, Baicalein and Wogonin in Plasma after Oral Administration of Pure Baicalin, Radix Scutellariae and Scutellariae-Paeoniae Couple Extracts in Normal and Ulcerative Colitis Rats
- in-vivo, Nor, NA
*BioAv↝, *other↝,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2604- Ba,  BA,    Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats
- in-vivo, Nor, NA
*BioAv↝, *BioAv↝,
2672- BBR,    The anti-aging mechanism of Berberine associated with metabolic control
- Review, Var, NA
*BioAv↝, *BioAv↝, *BioAv↝, *Half-Life↓,
3678- BBR,    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
- Review, AD, NA
*APP↓, *PPARγ↑, *NF-kB↓, *Aβ↓, *cognitive↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *BioAv↑, *BioAv↝, *BBB↑, *motorD↑, *NRF2↑, *HO-1↑, *ROS↓, *p‑Akt↑, *p‑ERK↑,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
6512- BCP,    Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
- in-vitro, MM, NA
CB2 / CNR2↑, BAX↑, Bcl-2↓, Casp3↑, TumCP↓, Apoptosis↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Inflam↓, chemoPv↑, neuroP↑, *BioAv↝, CB2 / CNR2↑, tumCV↓,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,
5655- BNL,    Comparative pharmacokinetic studies of borneol in mouse plasma and brain by different administrations
- in-vivo, Nor, NA
*BioAv↝, BioAv↓, BioAv↑,
8361- Brocc,  SFN,    Impact of thermal processing on sulforaphane yield from broccoli ( Brassica oleracea L. ssp. italica)
- Study, Nor, NA
*BioAv↝,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5927- CAR,    Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2/PTGS2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑, *CompStab↑,
6635- Cen,    Pharmacokinetics and metabolomics investigation of an orally modified formula of standardized Centella asiatica extract in healthy volunteers
- Trial, Nor, NA
*BioAv↝, *eff↑, *Choline↑, *memory↑, *cognitive↑, *neuroP↑, *BioAv↑,
6662- Cen,    Assessment report on Centella asiatica (L.) Urban, herba
- Review, Nor, NA
*cognitive↑, *Inflam↓, *AntiBio↑, *Imm↑, *antiOx↑, *Wound Healing↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *MDA↓, *lipid-P↓, *ROS↓, *memory↑, *GABA↑, *antiPs↑, *BioAv↝,
6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,
6015- CGA,    Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats
- in-vivo, Nor, NA
*BioAv↝,
6004- CGA,    Dose-response plasma appearance of coffee chlorogenic and phenolic acids in adults
- Human, Nor, NA
*BioAv↝, *other↝, BioAv↓,
6013- CGA,    Advances in Pharmacological Properties, Molecular Mechanisms, and Bioavailability Strategies of Chlorogenic Acid in Cardiovascular Diseases Therapy
- Review, CardioV, NA
*BioAv↝, *BioAv↝, *BP↓, *ROS↓, *NADPH↓, *AntiAg↑, *TXA2↓, *antiOx↑, *cardioP↑, *Inflam↓, *SOD↑, *Catalase↑, *Ferroptosis↓, *NF-kB↓, *JNK↓, *NRF2↑, *HO-1↑, *toxicity↓, *BioAv↓, *BioAv↑, *BioAv↑, Synergy↑,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6043- CGA,  SeNPs,    Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid β Aggregation and Reactive Oxygen Species Formation In Vitro
- in-vitro, AD, NA
*ROS↓, *Aβ↓, *BioAv↝, *BioAv↑, *Dose↝, *ROS↓, *H2O2↓, *toxicity↓, CompStab↓,
6026- CGA,    Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression
- Review, Var, NA
ChemoSen↑, AMPK↑, EGFR↓, PI3K↓, mTOR↓, Hif1a↓, VEGF↓, MAPK↓, ERK↓, DNAdam↑, TOP1↓, TOP2↓, Apoptosis↑, *BioAv↝, *Half-Life↓,
5987- Chit,    Chitin, Chitosan, and Glycated Chitosan Regulate Immune Responses: The Novel Adjuvants for Cancer Vaccine
- Review, Var, NA
other↝, other↝, *Weight↝, *toxicity↓, *Bacteria↓, *BioAv↑, DDS↑, *Wound Healing↑, *other↝, *Imm↑, eff↑, *BioAv↝, *BioAv↑, eff↑, NK cell↑, IL2↑, IFN-γ↑, IL10↑,
6098- Chol,    Choline
- Review, Nor, NA - Review, AD, NA
*BioAv↝, *Dose↝, *cardioP↑, *BP↓, *cognitive↑, *memory↑, eff∅,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, Synergy↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
9274- CRAN,    Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability
- Trial, Nor, NA
*Dose?, *BioAv↝, *BioAv↝,
6311- Cro,    Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model
- in-vivo, Nor, NA
*BioAv↝, *BioAv↑,
6307- Cro,    Effects of Intestinal Microbiota on Pharmacokinetics of Crocin and Crocetin in Male Sprague-Dawley Rats
- in-vivo, Nor, NA
*BioAv↝,
7427- CS,  Poly,    Polyphenols from artichoke heads (Cynara cardunculus (L.) subsp. scolymus Hayek): in vitro bio-accessibility, intestinal uptake and bioavailability
- Study, Nor, NA
*BioAv↓, *BioAv↝,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
4651- CUR,    Targeting cancer stem cells by curcumin and clinical applications
- Review, Var, NA
CSCs↓, *toxicity↓, *BioAv↝, chemoP↑,
2817- CUR,    Neuroprotection by curcumin: A review on brain delivery strategies
- Review, Nor, NA
*BioAv↝, neuroP↑,
6670- Deg,    Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats
- in-vivo, Nor, NA
*Half-Life↑, *BioAv↝,

Showing Research Papers: 1 to 50 of 147
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 147

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

GPx↑, 1,   GSH↓, 1,   H2O2↑, 1,   HO-1↑, 2,   Iron↝, 1,   lipid-P↓, 2,   lipid-P↑, 2,   NADH↓, 1,   NQO1↑, 3,   NRF2↑, 3,   ROS↓, 7,   ROS↑, 19,   ROS⇅, 2,   ROS↝, 2,   i-ROS↑, 1,   mt-ROS↑, 1,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 2,   compI↓, 1,   compIV↓, 1,   mtDam↓, 1,   mtDam↑, 3,   OXPHOS↓, 2,   PDH↑, 2,   PGC-1α↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   ALAT↓, 1,   AMPK↑, 5,   ATP↓, 2,   FASN↓, 1,   FDG↓, 1,   GlucoseCon↓, 1,   GlutMet↓, 1,   Glycolysis↓, 3,   Glycolysis↝, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HK2↓, 1,   lactateProd↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   TCA↓, 2,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis↑, 31,   Bak↑, 1,   BAX↑, 15,   Bcl-2↓, 16,   Bcl-2↑, 2,   Bcl-xL↓, 2,   Casp↑, 2,   Casp3↑, 18,   Casp3↝, 1,   Casp7↑, 3,   Casp8↑, 4,   pro‑Casp8↑, 1,   Casp9↑, 11,   Cyt‑c↑, 5,   DR5↑, 2,   FADD↑, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   IAP2/BIRC3↑, 1,   ICD↑, 1,   iNOS↓, 3,   Mcl-1↓, 3,   MDM2↓, 1,   MOMP↑, 2,   p38↓, 1,   p38↑, 2,   pS2/TFF1↓, 1,   PUMA↓, 1,   survivin↓, 6,   TumCD↑, 2,   XIAP↓, 3,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 28,   Akt↑, 2,   p‑Akt↓, 3,   cMET↓, 1,   EGFR↓, 6,   ERK↓, 10,   p‑ERK↓, 1,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IκB↓, 1,   JAK↓, 1,   JAK2↓, 1,   JNK↓, 1,   JNK↑, 3,   MAPK↓, 4,   MAPK↑, 1,   MARK4↓, 1,   mTOR↓, 15,   p‑mTOR↓, 2,   p‑P70S6K↓, 1,   PI3K↓, 23,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PKCδ↓, 1,   PTEN↑, 7,   RAS↓, 2,   STAT↓, 2,   STAT3↓, 9,   p‑STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

CBP↓, 1,   cJun↓, 1,   cMyc↓, 3,   DNMT1↓, 1,   DNMTs↓, 1,   EZH2↓, 3,   FOXM1↓, 2,   FOXO3↑, 2,   HATs↓, 1,   HDAC↓, 4,   HDAC2↓, 1,   HDAC3↓, 1,   miR-106b↓, 1,   miR-124-3p↓, 1,   miR-155↓, 1,   miR-34a↑, 3,   MTA2↓, 1,   MYCN↓, 1,   OCT4↓, 3,   other↝, 4,   SOX2↓, 2,   SOX4↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↑, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 2,   CTSK↓, 1,   LC3II↑, 2,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   BRCA1↓, 1,   DFF45↓, 1,   DNAdam↑, 3,   DNArepair↓, 1,   P53↑, 7,   PARP↑, 4,   cl‑PARP↑, 6,   PCNA↓, 3,   Telomerase↓, 1,   TOP1↓, 3,   TOP2↓, 2,   TOP2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 4,   CDK1↑, 2,   CDK2↓, 2,   CDK4↓, 3,   CDK4/6↓, 1,   CDK6↑, 1,   CDKN1C/p57↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 6,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 5,   cycD1/CCND1↑, 1,   E2Fs↓, 1,   Ki-67↓, 4,   P21↑, 5,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   TumCCA↑, 24,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   cFos↓, 2,   CSCs?, 1,   CSCs↓, 6,   FGF↓, 1,   Gli1↓, 1,   IGF-1↓, 1,   Ki-67↓, 4,   Let-7↑, 1,   Nanog↓, 1,   NOTCH↓, 2,   NOTCH1↓, 2,   NOTCH3↓, 1,   p300↓, 1,   STAT1↓, 1,   TumCG↓, 8,   TumCP↓, 20,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   Ca+2↑, 3,   E-cadherin↓, 1,   E-cadherin↑, 4,   EMT↓, 4,   EpCAM↓, 1,   p‑FAK↓, 1,   MALAT1↓, 1,   MMP2↓, 12,   MMP3↓, 2,   MMP7↓, 2,   MMP9↓, 14,   MMPs↓, 6,   MUC4↓, 1,   N-cadherin↓, 4,   Rac1↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 4,   TIMP2↑, 1,   TRIB3↑, 1,   TumCI↓, 11,   TumCMig↓, 14,   TumMeta↓, 5,   TumMeta↑, 1,   TumPF↓, 1,   Twist↓, 3,   uPA↓, 2,   uPAR↓, 1,   Vim↓, 1,   Zeb1↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 9,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 12,   angioG↑, 1,   EGR4↓, 1,   Hif1a↓, 7,   VCAM-1↓, 1,   VEGF↓, 8,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   MMP↓, 10,   MPT↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   CD44↓, 2,   CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 8,   CXCR4↓, 2,   FOXP3↑, 1,   Gal-3↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 2,   IL1β↓, 4,   IL2↑, 1,   IL6↓, 5,   Imm↑, 1,   Inflam↓, 6,   IRAK1↓, 1,   mPGES-1↓, 1,   NF-kB↓, 21,   p‑NF-kB↑, 1,   NK cell↑, 2,   p‑p65↓, 1,   PD-L1↓, 1,   PGE2↓, 2,   PSA↓, 4,   TNF-α↓, 7,   TNF-α↑, 1,   Treg lymp↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   AhR↓, 1,   AR↓, 2,   AR↝, 1,   PPARγ↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 4,   BioAv↑, 4,   BioAv↝, 1,   BioEnh?, 1,   ChemoSen↑, 28,   CompStab↓, 2,   CompStab↑, 1,   CompStab↝, 1,   CYP1A2↑, 1,   DDS↑, 1,   Dose↑, 1,   Dose↝, 6,   eff↓, 1,   eff↑, 7,   eff↝, 1,   eff∅, 1,   GSTM1↑, 1,   Half-Life↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   RadioS↑, 4,   selectivity↑, 5,   Synergy↑, 11,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↓, 2,   AR↝, 1,   AST↓, 1,   BRCA1↓, 1,   EGFR↓, 6,   EZH2↓, 3,   FOXM1↓, 2,   IL6↓, 5,   LDH↓, 2,   NOS2↑, 1,   PD-L1↓, 1,   PSA↓, 4,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   antiNeop↑, 1,   AntiTum↑, 9,   cardioP↑, 3,   chemoP↑, 9,   chemoPv↑, 6,   cognitive?, 1,   cognitive↑, 2,   hepatoP↑, 2,   neuroP↑, 4,   NP/CIPN↓, 1,   Obesity↓, 1,   OS∅, 1,   PFS↑, 1,   PFS∅, 1,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 2,   Risk↓, 3,   toxicity↓, 3,   TumVol↓, 3,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 338

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↓, 2,   antiOx↑, 49,   ARE↑, 2,   Catalase↑, 17,   Fenton↓, 1,   GPx↑, 20,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 20,   GSR↑, 2,   GSTs↓, 1,   GSTs↑, 7,   H2O2↓, 3,   H2O2∅, 2,   HDL↑, 3,   HDL∅, 1,   HNE↓, 1,   HO-1↓, 1,   HO-1↑, 14,   HO-2↓, 1,   Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 9,   MDA↓, 13,   MPO↓, 6,   NADH↓, 1,   NQO1↑, 4,   NQO1∅, 1,   NRF2?, 1,   NRF2↑, 21,   RNS↓, 3,   ROS?, 1,   ROS↓, 57,   ROS↑, 2,   ROS⇅, 2,   SOD↑, 28,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 3,   TBARS↓, 1,   VitC↑, 2,   VitE↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   IronCh↑, 7,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   Insulin↓, 1,   Insulin↝, 1,   MFN2↑, 1,   mtDam↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 2,   adiP↑, 1,   ALAT↓, 5,   ALAT∅, 1,   AMPK↑, 6,   AMPK↝, 1,   ATP↑, 5,   cAMP↑, 1,   FABP4↓, 1,   FFA/NEFA↓, 1,   glucose↓, 4,   glucose↝, 1,   GlucoseCon↑, 3,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   HMG-CoA↓, 1,   LDL↓, 7,   NAD↑, 1,   NADPH↓, 1,   NADPH↑, 3,   PFK↓, 1,   PLA2↓, 1,   SIRT1↑, 6,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 6,   Bax:Bcl2↓, 1,   Bcl-2↑, 2,   Casp12↓, 1,   Casp3↓, 6,   Casp6↓, 1,   Casp9↓, 3,   Casp9↑, 1,   Fas↓, 1,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 7,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 10,   Akt↝, 1,   p‑Akt↑, 1,   AMPKα↑, 1,   CREB↑, 3,   ERK↓, 1,   ERK↑, 2,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   JAK↓, 2,   JAK2↑, 1,   JNK↓, 3,   p‑JNK↓, 1,   MAPK↓, 6,   MAPK↑, 1,   MAPK↝, 1,   mTOR↓, 1,   mTOR↑, 1,   mTOR↝, 1,   PDGFR-BB↓, 1,   PI3K↑, 5,   PI3K↝, 1,   PKCδ↓, 1,   PKCδ↑, 2,   PP2A↑, 1,   PTEN↓, 2,   STAT3↓, 2,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 5,   ATF2↑, 1,   ATF4↓, 1,   FOXO3↑, 1,   HDAC↑, 1,   other?, 2,   other↓, 4,   other↑, 4,   other↝, 21,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 2,   GRP94↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 2,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   Choline↑, 1,   HH↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 2,   NOTCH1↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 9,   AP-1↓, 2,   Ca+2↑, 1,   Cartilage↑, 1,   COL1↓, 1,   MMP13↓, 1,   MMP2↓, 2,   MMP9↓, 3,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   uPA↑, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 5,   TXA2↓, 1,   VCAM-1↓, 3,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 3,   BBB↑, 15,   GastroP↑, 1,   GLUT2↑, 1,   GLUT4↑, 2,   H+/K+-ATPase↓, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↑, 4,   TRPV1↑, 1,   TRPV3↑, 1,   VGSC↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↑, 1,   CD40↓, 1,   COX1↓, 4,   COX2/PTGS2↓, 19,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↓, 2,   IL10↑, 4,   IL17↓, 1,   IL18↓, 1,   IL1α∅, 1,   IL1β↓, 18,   IL1β∅, 1,   IL2↓, 1,   IL33↓, 1,   IL4↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 24,   IL8↓, 5,   IL8↑, 1,   IL8∅, 1,   Imm↑, 6,   Imm↝, 1,   Inflam?, 1,   Inflam↓, 58,   Inflam↑, 2,   IP-10/CXCL-10↓, 1,   LPS↓, 1,   MCP1/CCL2↓, 1,   MCP1/CCL2∅, 1,   NeuroI↓, 1,   NF-kB↓, 24,   p‑NF-kB↓, 1,   NLRP3↓, 4,   NLRP3↑, 1,   PGE2↓, 4,   TLR2↓, 1,   TLR3↓, 1,   TLR4↓, 4,   TNF-α↓, 27,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   Ach↑, 4,   AChE↓, 10,   ADAM10↑, 2,   BChE↓, 4,   BDNF↑, 9,   ChAT↑, 3,   GABA↑, 1,   MAOA↓, 4,   MAOB↓, 2,   NGF↑, 3,   PSD95↑, 1,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APOE4↓, 1,   APP↓, 3,   cl‑APP↑, 1,   Aβ↓, 14,   Aβ42↓, 2,   BACE/β-secretase↓, 6,   PSEN1/PS1↑, 1,   tau↓, 5,   p‑tau↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   CYP19↓, 1,   PPARα↑, 2,   PPARγ↓, 2,   PPARγ↑, 3,   p‑PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 34,   BioAv↑, 53,   BioAv⇅, 1,   BioAv↝, 179,   ChemoSen↑, 2,   CompStab↓, 1,   CompStab↑, 4,   CompStab↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,   CYP2E1↓, 1,   Dose?, 3,   Dose↑, 1,   Dose↝, 39,   Dose∅, 1,   eff↓, 2,   eff↑, 24,   eff↝, 1,   GSTA1↑, 1,   Half-Life?, 2,   Half-Life↓, 11,   Half-Life↑, 4,   Half-Life↝, 27,   Half-Life∅, 1,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALAT∅, 1,   anemia↓, 1,   AST↓, 5,   AST∅, 1,   BG↓, 1,   BloodF↑, 4,   BP↓, 5,   BP↝, 1,   creat↓, 2,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   IL6↓, 24,   IRes↓, 1,   IRes↝, 1,   LDH↓, 1,   NOS2↓, 1,   RBC↑, 1,   TG/TAG↓, 1,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 3,   antiAll↑, 7,   AntiArt↑, 3,   AntiCan↓, 1,   AntiCan↑, 15,   AntiDiabetic↓, 1,   AntiDiabetic↑, 12,   AntiMyl↑, 1,   antiPs↑, 2,   AntiTum↑, 2,   cardioP↓, 1,   cardioP↑, 26,   CardioT↓, 1,   chemoP↑, 5,   chemoPv↑, 5,   cognitive↑, 26,   cough?, 1,   diuretic↑, 1,   hepatoP↓, 1,   hepatoP↑, 19,   Learn↑, 2,   memory↑, 20,   motorD↑, 3,   neuroP↑, 46,   neuroP↝, 1,   Obesity↓, 9,   OS↑, 2,   Pain↓, 3,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 1,   Sleep↑, 1,   SoreThr?, 1,   Stroke↓, 7,   toxicity↓, 13,   toxicity↑, 1,   toxicity↝, 7,   toxicity∅, 1,   Weight↓, 1,   Weight↝, 1,   Wound Healing↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 7,   AntiFungal↑, 3,   AntiViral↑, 4,   Bacteria↓, 12,   Diar↓, 1,   GutMicro↑, 11,   GutMicro↝, 1,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,   Ingr↑, 2,   Ingr↝, 2,  
Total Targets: 369

Scientific Paper Hit Count for: BioAv, bioavailability
6 Alpha-Lipoic-Acid
6 Chlorogenic acid
4 Baicalein
4 SDG/lignans
4 Lycopene
4 Silymarin (Milk Thistle) silibinin
3 Sulforaphane (mainly Broccoli)
3 Centella asiatica / Gotu kola → asiaticoside
3 Hydroxycinnamic-acid
3 Curcumin
3 Diindolylmethane
3 Eugenol
3 HydroxyTyrosol
3 Isovitexin
3 Kaempferol
3 Magnolol
3 Mangiferin
3 Morin
3 Urolithin
2 Silver-NanoParticles
2 Ashwagandha(Withaferin A)
2 Baicalin
2 Berberine
2 Beta-Caryophyllene
2 Phenethyl isothiocyanate
2 Broccoli
2 Crocetin
2 Indole-3-carbinol
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Flaxseed/Linseed
2 phytic acid, Inositol hexakisphosphate
2 Fucoidan
2 Garcinol
2 Hydrogen Gas
2 Isoliquiritigenin
2 Licorice
2 Lactoferrin/Talactoferrin
2 Methyl salicylate / Sweet Birch oil
2 Quercetin
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Naringin
2 Resveratrol
2 Rosmarinic acid
2 Rutin
2 Thymoquinone
1 Açaí, Euterpe oleracea
1 Auranofin
1 Allicin (mainly Garlic)
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Aspirin
1 Astaxanthin
1 xanthohumol
1 Benzyl isothiocyanate
1 Allyl isothiocyanate
1 borneol
1 Capsaicin
1 Carvacrol
1 Selenium NanoParticles
1 chitosan
1 Choline
1 Cinnamon
1 Cranberry
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Polyphenols
1 Deguelin
1 Eurycomanone
1 Folic Acid, Vit B9
1 Formononetin
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Germacranolide sesquiterpene lactone
1 Huperzine A/Huperzia serrata
1 Inositol
1 isoflavones
1 Isothiocyanates
1 Ivermectin
1 L-Theanine
1 Luteolin
1 Honokiol
1 Matrine
1 Metformin
1 nicotinamide adenine dinucleotide
1 buckwheat sprouts
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Thymol-Thymus vulgaris
1 Vitamin B3,Niacin
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:792  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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