Half-Life Cancer Research Results

Half-Life, Half-Life: Click to Expand ⟱
Source:
Type:
For many drugs, the half-life is the time it takes for half of the drug’s active substance to be eliminated from the bloodstream.
In medicine, knowing a drug’s half-life helps in designing treatment regimens that reduce adverse effects.
Scientific Papers found: Click to Expand⟱
1916- AL,    Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods
- Review, Nor, NA
*BioAv↝, *eff↓, *BioAv↝, *BioAv↝, *eff↑, *Half-Life∅, *eff↑, *eff↑, *Dose∅, *eff↑,
1548- Api,    A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms
- Review, Colon, NA
*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1 / PDPK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
1614- EA,    Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice
- Human, Nor, NA
*BioEnh↝, *Half-Life∅,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, Var, NA
*Dose∅, *Half-Life∅, *BioAv∅, *BBB↑, *toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
1732- SFN,    Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
- in-vitro, BC, MCF7 - in-vitro, BC, SUM159 - in-vivo, NA, NA
TumCD↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, *BioAv↑, angioG↓, VEGF↓, Hif1a↓, MMP2↓, MMP9↓, Casp3↑, *Half-Life∅,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GlucoseCon↓, 1,   Glycolysis↓, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bak↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 3,   Cyt‑c↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   mTOR↓, 1,   mTOR⇅, 1,   PI3K↓, 1,   PTEN↑, 2,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMTs↓, 1,   H3↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   miR-30a-5p↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 2,   cl‑PARP↑, 2,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   p‑RB1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   IGF-1↓, 1,   TumCG↓, 1,   TumCP↓, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

EMT↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   TSC1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 4,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Dose∅, 2,   eff↓, 2,   eff↑, 3,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

E6↓, 1,   E7↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   CardioT↓, 1,   neuroP↑, 2,  
Total Targets: 68

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 3,   BioAv∅, 1,   BioEnh↑, 1,   BioEnh↝, 1,   Dose∅, 2,   eff↓, 1,   eff↑, 4,   Half-Life∅, 7,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   toxicity∅, 2,  
Total Targets: 16

Scientific Paper Hit Count for: Half-Life, Half-Life
2 Ellagic acid
2 Sulforaphane (mainly Broccoli)
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 EGCG (Epigallocatechin Gallate)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1109  State#:%  Dir#:6
  wNotes=0  sortOrder:rid,rpid

 

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