BDNF Cancer Research Results

BDNF, brain-derived neurotrophic factor: Click to Expand ⟱
Source:
Type:
Brain-Derived Neurotrophic Factor (BDNF) is a key neurotrophin (a type of growth factor) involved in brain health, and its role in Alzheimer’s Disease (AD) has been extensively studied.
-AD patients often have lower BDNF levels in key brain regions, such as the hippocampus and cortex.
-This reduction correlates with cognitive decline and brain atrophy.
-BDNF normally protects neurons from Aβ toxicity
-Exercise and cognitive training have been shown to boost BDNF levels and may slow cognitive decline.
- natural compounds (like curcumin or flavonoids) may also upregulate BDNF.
Scientific Papers found: Click to Expand⟱
6624- Cic,    Chicoric acid supplementation ameliorates cognitive impairment induced by oxidative stress via promotion of antioxidant defense system
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *TNF-α↓, *IL1β↓, *MDA↓, *Catalase↑, *GSH↑, *NRF2↑, *mtDam↓, *Inflam↓, *Apoptosis↓, *ROS↓, *cognitive↑, *Aβ↓, *BDNF∅, *APP↓, *BACE/β-secretase↓,
6625- Cic,  Ech,    Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB
- in-vivo, AD, NA
*memory↑, *Aβ↓, *BACE/β-secretase↓, *MAPK↓, *NF-kB↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *BDNF∅, *MMPs↓,
4244- GBE,    Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men
- Human, Nor, NA
*BDNF∅,
7670- GCL2505,    Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial
- Trial, AD, NA
*cognitive↑, *GutMicro↑, *Inflam↓, *Dose↝, *BDNF∅,
4173- TQ,    Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons
- in-vivo, Nor, NA
*neuroP↑, *Casp3↓, *Apoptosis↓, *ERK↑, *JNK↑, *CREB↑, *iNOS↑, *BDNF∅,
4186- VitD3,    The Association of Vitamin D, Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell-Derived Neurotrophic Factor (GDNF) with Development in Children
- Study, Nor, NA
*BDNF∅,
4185- VitD3,    Effects of vitamin D supplementation on neuroplasticity in older adults: a double-blinded, placebo-controlled randomised trial
- Study, AD, NA
*other↑, *BDNF∅,
4196- Z,    The effect of zinc supplementation on brain derived neurotrophic factor: A meta-analysis
- Review, AD, NA
*BDNF∅,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GSH↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   Casp3↓, 1,   iNOS↓, 1,   iNOS↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CREB↑, 1,   ERK↑, 1,   JNK↑, 1,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Migration(tgid=13) ⓘ

MMPs↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 2,   Inflam↓, 2,   NF-kB↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF∅, 8,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 2,   BACE/β-secretase↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 2,   memory↑, 1,   neuroP↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 30

Scientific Paper Hit Count for: BDNF, brain-derived neurotrophic factor
2 Cichoric acid / Chicoric acid
2 Vitamin D3
1 Echinacea
1 Ginkgo biloba
1 Bifidobacterium animalis subsp. lactis GCL2505
1 Thymoquinone
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1356  State#:%  Dir#:6
  wNotes=0  sortOrder:rid,rpid

 

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