Wnt/(β-catenin) Cancer Research Results

Wnt/(β-catenin), Wnt/(β-catenin): Click to Expand ⟱
Source: HalifaxProj (inhibit) TCGA
Type:
The Wnt signaling pathway is activated when Wnt proteins bind to Frizzled receptors on the cell surface, leading to the stabilization and accumulation of β-catenin in the cytoplasm and its subsequent translocation to the nucleus.
In the nucleus, β-catenin interacts with transcription factors to activate target genes that promote cell growth and survival.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, NA, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumMeta↓, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, Hif1a↓, Wnt/(β-catenin)↓, AXIN1↑, TumVol↓, TumW↓,
805- GAR,  Cisplatin,  PacT,    Garcinol Exhibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells
- Review, NA, NA
ERK↓, PI3K/Akt↓, Wnt/(β-catenin)↓, STAT3↓, NF-kB↓, ChemoSen↑, COX2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, VEGF↓, TGF-β↓, HATs↓, E-cadherin↑, Vim↓, Zeb1↓, ZEB2↓, Let-7↑, MMP9↓, TumCCA↑, ROS↑, MMP↓, IL6↓, NOTCH1↓,
978- SIL,    A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment
- Review, NA, NA
PI3K↓, Akt↓, NF-kB↓, Wnt/(β-catenin)↓, MAPK↓, TumCP↓, TumCCA↑, Apoptosis↑, p‑EGFR↓, JAK2↓, STAT5↓, cycD1/CCND1↓, hTERT/TERT↓, AP-1↓, MMP9↓, miR-21↓, miR-155↓, Casp9↑, BID↑, ERK↓, Akt2↓, DNMT1↓, P53↑, survivin↓, Casp3↑, ROS↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   PI3K/Akt↓, 1,   p‑S6↓, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 4,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-xL↓, 1,   BID↑, 1,   Casp3↑, 2,   Casp9↑, 2,   p‑Chk2↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   MAPK↓, 1,   oncosis↑, 1,   p27↑, 1,   survivin↓, 2,  

Transcription & Epigenetics ⓘ

HATs↓, 1,   miR-21↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

p‑ATM↑, 1,   p‑ATR↑, 1,   p‑CHK1↑, 1,   DNAdam↑, 2,   DNMT1↓, 1,   HR↓, 1,   p16↑, 1,   P53↑, 2,   RAD51↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

AXIN1↑, 1,   cMET↓, 1,   EMT↓, 1,   ERK↓, 4,   p‑ERK↓, 1,   Let-7↑, 1,   mTOR↓, 2,   NOTCH1↓, 1,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 3,   STAT3↓, 2,   STAT5↓, 1,   Wnt/(β-catenin)↓, 5,  

Migration ⓘ

Akt2↓, 1,   AP-1↓, 1,   CDK4/6↓, 1,   E-cadherin↑, 2,   ITGB1↑, 1,   miR-155↓, 1,   MMP2↓, 2,   MMP9↓, 3,   N-cadherin↓, 1,   NCAM↑, 1,   Snail↓, 1,   TGF-β↓, 2,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 3,   TumMeta↓, 1,   Vim↓, 2,   Zeb1↓, 1,   ZEB2↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   p‑EGFR↓, 1,   Hif1a↓, 3,   KDR/FLK-1↓, 1,   NO↓, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IKKα↓, 1,   IL1↓, 1,   IL1α↓, 1,   IL6↓, 3,   JAK2↓, 1,   MIP2↓, 1,   NF-kB↓, 3,   PGE2↓, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   p‑EGFR↓, 1,   hTERT/TERT↓, 1,   IL6↓, 3,  

Functional Outcomes ⓘ

TumVol↓, 1,   TumW↓, 1,  
Total Targets: 97

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Wnt/(β-catenin), Wnt/(β-catenin)
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Cannabidiol
1 Garcinol
1 Cisplatin
1 Paclitaxel
1 Silymarin (Milk Thistle) silibinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:338  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page