lipid-P Cancer Research Results

lipid-P, lipid peroxidation: Click to Expand ⟱
Source:
Type:
Lipid peroxidation is a chain reaction process in which free radicals (often reactive oxygen species, or ROS) attack lipids containing carbon-carbon double bonds, especially polyunsaturated fatty acids. This attack results in the formation of lipid radicals, peroxides, and subsequent breakdown products.
Lipid peroxidation can cause damage to cell membranes, leading to increased permeability and disruption of cellular functions. This damage can initiate a cascade of events that may contribute to carcinogenesis.
The byproducts of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), can form adducts with DNA, leading to mutations. These mutations can disrupt normal cellular processes and contribute to the development of cancer.
Lipid peroxidation damages cell membranes, disrupts cellular functions, and can trigger inflammatory responses. It is a marker of oxidative stress and is implicated in many chronic diseases.

Negative Prognostic Indicator: In many cancers, high levels of lipid phosphates, particularly S1P, are associated with poor prognosis, indicating a more aggressive tumor phenotype and potential resistance to therapy.
Mixed Evidence: The prognostic significance of lipid phosphates can vary by cancer type, with some studies showing that their expression may not always correlate with adverse outcomes.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
4282- ALA,    Effect of add-on alpha lipoic acid on psychopathology in patients with treatment-resistant schizophrenia: a pilot randomized double-blind placebo-controlled trial
- Trial, NA, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *adiP↑, *cognitive∅, *BDNF↑,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3540- ALA,    Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?
- in-vitro, NA, NA
*lipid-P↓, *H2O2↓, *IronCh↑,
4259- Cin,    The Potential of Cinnamon as Anti-Depressant
- Review, NA, NA
*Inflam↓, *BDNF↑, *TNF-α↓, *lipid-P↓, *Mood↑,
3890- Cin,    The Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases
- Review, NA, NA
*cardioP↑, *Inflam↓, *ROS↓, *lipid-P↓, *AntiAg↑, *angioG↑, *GutMicro↑, *ER Stress↓,
3635- Cro,    A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
- Review, NA, NA
*memory↑, *cognitive↑, *BioAv↑, *ROS↓, *IL1↓, *TNF-α↓, *NF-kB↓, *neuroP↑, *lipid-P↓, *Thiols↑, *antiOx↑, *AChE↓, *MAOA↝, *SIRT1↑, *PGC-1α↑, *Ach↑,
1571- Cu,    Copper in cancer: From pathogenesis to therapy
- Review, NA, NA
*toxicity↝, ROS↑, lipid-P↓, HNE↑, MAPK↑, JNK↑, AP-1↑, Beclin-1↑, ATG7↑, TumAuto↑, Apoptosis↑, HO-1↑, NQO1↑, mt-ROS↑, Fenton↑,
4338- LT,    Luteolin: a natural product with multiple mechanisms for atherosclerosis
- Review, NA, NA
*Inflam↓, *ROS↓, *PDGF↓, *lipid-P↓, *AMPK↑, *SIRT1↑, *AntiAg↑,
3844- Moringa,    Review of the Safety and Efficacy of Moringa oleifera
- Review, NA, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, NA, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, NA, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *eff↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2↓, *mTOR↑,
4440- SeNPs,  AgNPs,    Selenium, silver, and gold nanoparticles: Emerging strategies for hepatic oxidative stress and inflammation reduction
- Review, NA, NA
*hepatoP↑, *antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *GPx↑, *lipid-P↓,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, NA, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
3648- SIL,    Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
- Review, NA, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *necrosis↓, *hepatoP↑, *IL1↓, *IL6↓, *TNF-α↓, *IFN-γ↓, MAPK↓, Apoptosis↑, Cyt‑c↑, Casp3↑, Casp9↑, *PPARγ↑, *GLUT4↑, *HSPs↓, *HSP27↑, *Trx↑, *SIRT1↑, *ALAT↓, *GSH↑, *lipid-P↓, *TNF-α↓, TumCG↓, P21↑, CDK4↑,
3295- SIL,    Hepatoprotective effect of silymarin
- Review, NA, NA
*hepatoP↑, *ROS↓, *GSH↑, *BioAv↝, ERK↓, NF-kB↓, STAT3↓, COX2↓, Inflam↓, IronCh↑, lipid-P↓, ALAT↓, AST↓, TNF-α↓, *α-SMA↓, *SOD↑,

Showing Research Papers: 1 to 16 of 16

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 16

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

CYP1A1↑, 1,   Fenton↑, 1,   HNE↑, 1,   HO-1↑, 1,   lipid-P↓, 3,   NQO1↑, 1,   ROS↑, 4,   mt-ROS↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

e-Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   ATG7↑, 1,   GLO-I↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 2,   Mcl-1↓, 1,   p38↓, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↑, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   p‑mTOR↓, 1,   RAS↓, 1,   STAT3↓, 3,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

AntiAg↑, 1,   AP-1↑, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCP↓, 1,   VCAM-1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   HIF-1↑, 1,   VEGF↓, 2,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   chemoP↑, 1,  
Total Targets: 63

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 7,   Bil↓, 1,   Catalase↑, 1,   Fenton↓, 1,   GPx↑, 2,   GSH↑, 5,   GSR↑, 1,   GSSG↓, 1,   GSTs↑, 1,   H2O2↓, 1,   lipid-P↓, 14,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 10,   ROS↑, 1,   SOD↑, 4,   Thiols↑, 1,   Trx↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

Acetyl-CoA↑, 1,   adiP↑, 1,   ALAT↓, 4,   AMPK↑, 1,   GlucoseCon↑, 1,   PPARγ↑, 1,   SIRT1↑, 3,  

Cell Death ⓘ

iNOS↓, 2,   necrosis↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   HSP27↑, 1,   HSPs↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↑, 1,   OCT4↓, 1,  

Migration ⓘ

AntiAg↑, 3,   MMP2↓, 1,   PDGF↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   angioG↑, 1,   eNOS↓, 1,   NO↓, 1,  

Barriers & Transport ⓘ

GLUT4↑, 1,   OATPs↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IFN-γ↓, 2,   IL1↓, 2,   IL2↓, 1,   IL4↓, 1,   IL6↓, 2,   Inflam↓, 9,   NF-kB↓, 3,   PGE2↓, 2,   TNF-α↓, 6,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 2,   ChAT↑, 1,   MAOA↝, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   eff↑, 2,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 4,   ALP↓, 1,   AST↓, 3,   Bil↓, 1,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 2,   cognitive↑, 2,   cognitive∅, 1,   hepatoP↑, 7,   memory↑, 2,   Mood↑, 1,   neuroP↑, 3,   radioP↑, 1,   RenoP↑, 2,   toxicity↓, 1,   toxicity↝, 1,   Weight↓, 1,  
Total Targets: 84

Scientific Paper Hit Count for: lipid-P, lipid peroxidation
3 Alpha-Lipoic-Acid
3 Silymarin (Milk Thistle) silibinin
2 Cinnamon
1 Crocetin
1 Copper and Cu NanoParticles
1 Luteolin
1 Moringa oleifera
1 Naringin
1 Quercetin
1 Rosmarinic acid
1 Selenium NanoParticles
1 Silver-NanoParticles
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:453  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page