TfR1/CD71 Cancer Research Results

TfR1/CD71, Transferrin receptor protein 1,: Click to Expand ⟱
Source:
Type: gene/protein
Also called CD71
A protein that in humans is encoded by the TFRC gene. A protein that mediates iron uptake from transferrin into cells.
Transferrin receptor, which can control iron metabolism, is frequently expressed in tumor cells.
As is well known, TfR1 binds to iron-loaded transferrin and plays a pivotal role in cellular uptake of iron as well as ferritin sequesters and stores the cellular iron.


NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
576- ART/DHA,    Profiling of Multiple Targets of Artemisinin Activated by Hemin in Cancer Cell Proteome
- Analysis, NA, NA
GSTP1/GSTπ↓, TfR1/CD71↓,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, NA, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, NA, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSTP1/GSTπ↓, 1,  

Metal & Cofactor Biology ⓘ

TfR1/CD71↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GPx↑, 1,   Iron↓, 2,   MDA↓, 1,   ROS↓, 2,   SOD↑, 1,  

Metal & Cofactor Biology ⓘ

FTL↓, 1,   TfR1/CD71↓, 2,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,   NADPH↓, 1,  

Cell Death ⓘ

Bax:Bcl2↓, 1,   Casp3↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,  

Migration ⓘ

PKA↑, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 2,   PSD95↑, 2,  

Functional Outcomes ⓘ

cognitive↑, 2,   neuroP↑, 2,  
Total Targets: 18

Scientific Paper Hit Count for: TfR1/CD71, Transferrin receptor protein 1,
2 Huperzine A/Huperzia serrata
1 Artemisinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:465  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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