CD44 Cancer Research Results
CD44, CD44: Click to Expand ⟱
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CD44 represents a common biomarker of cancer stem cells, and promotes epithelial-mesenchymal transition. CD44 is a well-known marker of CSCs and plays important roles in tumor initiation and development.
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NA, Not Available: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
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Review, |
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AD, |
NA |
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NF-kB↓, P450↓, COX2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,
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in-vivo, |
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4T1 |
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CSCs↓, TumCG↓, Diff↑, selectivity↑, CD44↓, CD24↓, TumVol↓,
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
Showing Research Papers: 1 to 3 of 3
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
ROS↓, 1, ROS↑, 1,
Mitochondria & Bioenergetics ⓘ
ATP↓, 1, MMP↓, 2,
Core Metabolism/Glycolysis ⓘ
AMPK↑, 1, cMyc↓, 1, HK2↓, 1, SIRT1↓, 2, SIRT2↓, 1, SREBP1↓, 1,
Cell Death ⓘ
Akt↓, 1, Casp↑, 1, Cyt‑c↑, 1, p27↑, 1, Telomerase↓, 1,
Transcription & Epigenetics ⓘ
HATs↑, 1,
DNA Damage & Repair ⓘ
DNAdam↑, 1, TP53↑, 1,
Cell Cycle & Senescence ⓘ
CDK4↓, 1, P21↑, 2, TumCCA↑, 1,
Proliferation, Differentiation & Cell State ⓘ
ALDH↓, 1, CD24↓, 1, CD44↓, 3, CSCs↓, 2, Diff↑, 1, EMT↓, 2, ERK↓, 1, HDAC↓, 1, IGFBP3↑, 1, Nanog↓, 1, Nestin↓, 1, NOTCH↓, 1, PTEN↑, 1, Shh↓, 1, STAT3↓, 2, TCF↓, 1, TOP2↓, 1, TumCG↓, 2, Wnt↓, 2,
Migration ⓘ
CA↓, 1, Ca+2↑, 1, E-cadherin↑, 2, FAK↓, 1, MALAT1↓, 1, miR-203↑, 1, MMP2↓, 1, MMP7↓, 1, MMP9↓, 1, PDGF↓, 1, Slug↓, 1, TGF-β↓, 1, TumCMig↓, 1, uPA↓, 1, Vim↓, 2, Zeb1↓, 1, β-catenin/ZEB1↓, 1,
Angiogenesis & Vasculature ⓘ
angioG↓, 1, EGFR↓, 1, Hif1a↓, 2, VEGF↓, 4,
Barriers & Transport ⓘ
NHE1↓, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 2, CXCR4↓, 1, IL1↓, 1, IL6↓, 1, NF-kB↓, 2, PD-L1↓, 1, PGE2↓, 1, PSA↓, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 3, ChemoSen⇅, 1, Dose↝, 1, eff↑, 1, eff↝, 1, Half-Life↓, 1, Half-Life↝, 1, MDR1↓, 1, P450↓, 1, RadioS↑, 1, selectivity↑, 2,
Clinical Biomarkers ⓘ
AR↓, 1, EGFR↓, 1, IL6↓, 1, PD-L1↓, 1, PSA↓, 1, TP53↑, 1,
Functional Outcomes ⓘ
AntiCan↑, 1, cardioP↑, 2, chemoP↑, 1, hepatoP↑, 1, toxicity↝, 1, toxicity∅, 1, TumVol↓, 1,
Total Targets: 95
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 1,
Core Metabolism/Glycolysis ⓘ
SIRT1↑, 2,
Migration ⓘ
TIMP1↓, 1,
Angiogenesis & Vasculature ⓘ
angioG↑, 1,
Immune & Inflammatory Signaling ⓘ
IL8↓, 1, Inflam↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 1,
Functional Outcomes ⓘ
memory↑, 1, neuroP↑, 1,
Total Targets: 9
Scientific Paper Hit Count for: CD44, CD44
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:0 Cells:% prod#:% Target#:48 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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