PCNA Cancer Research Results

PCNA, Proliferating Cell Nuclear Antigen: Click to Expand ⟱
Source:
Type:
Proliferating Cell Nuclear Antigen (PCNA) is a protein that plays a crucial role in DNA replication and repair. It acts as a processivity factor for DNA polymerase, helping to increase the efficiency of DNA synthesis. PCNA is also involved in various cellular processes, including cell cycle regulation, DNA damage response, and chromatin remodeling.
PCNA is often overexpressed in many types of tumors. This overexpression is associated with increased cell proliferation, which is a hallmark of cancer. The elevated levels of PCNA can serve as a biomarker for tumor growth and progression.
PCNA is called the “ringmaster of the genome” : it regulates the cell cycle and participates in DNA synthesis. PCNA is widely used as a cell proliferation marker in both healthy and malignant tissues.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, NA, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27↑, P21↑,
1938- PL,    Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
- Study, PSA, NA - in-vivo, NA, NA
ROS↑, Apoptosis↑, MMP↓, TumCCA↑, DNAdam↑, STAT3↓, Akt↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, Bcl-2↓, K17↓, HDAC↓, ROS↑, *IL1β↓, *IL6↓, *TNF-α↓, *IL17↓, *IL22↓,
4453- SeNPs,    Selenium Nanoparticles: Green Synthesis and Biomedical Application
- Review, NA, NA
*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   GSH↓, 1,   ROS↑, 3,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp9↑, 1,   HGF/c-Met↓, 1,   MAPK↓, 1,   p27↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 1,   PARP↑, 1,   PCNA↓, 3,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   HDAC↓, 1,   PI3K↓, 1,   STAT3↓, 2,  

Migration ⓘ

Ki-67↓, 2,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,   selectivity↓, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AR↓, 1,   Ki-67↓, 2,  

Functional Outcomes ⓘ

K17↓, 1,  
Total Targets: 35

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL17↓, 1,   IL1β↓, 1,   IL22↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   creat↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 14

Scientific Paper Hit Count for: PCNA, Proliferating Cell Nuclear Antigen
1 EGCG (Epigallocatechin Gallate)
1 Piperlongumine
1 Selenium NanoParticles
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:489  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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