TumMeta Cancer Research Results

TumMeta, Cancer Metastasis: Click to Expand ⟱
Source:
Type:
Cancer metastasis is the process by which cancer cells spread from the original (primary) tumor to other parts of the body, forming new (secondary) tumors. This occurs when cancer cells invade surrounding tissues, enter the bloodstream or lymphatic system, and travel to distant organs or tissues.


NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
4426- AgNPs,    Antiangiogenic properties of silver nanoparticles
- Study, NA, NA
angioG↑, TumCG↓, TumCI↓, TumMeta↓, VEGF↓, PI3K↓, Akt↓,
985- ART/DHA,    Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway
- in-vitro, Thyroid, TPC-1 - Human, NA, NA
XIST↓, Hif1a↓, Glycolysis↓, TumCCA↑, TumMeta↓,
1096- ASA,    Aspirin inhibit platelet-induced epithelial-to-mesenchymal transition of circulating tumor cells (Review)
- Review, NA, NA
TumMeta↓, COX1↓, CTC↓,
2738- BetA,    Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, NA, NA
TumCI↓, TumCMig↓, Glycolysis↓, lactateProd↓, GRP78/BiP↑, ER Stress↑, PERK↑, p‑eIF2α↑, β-catenin/ZEB1↓, cMyc↓, ROS↑, angioG↓, Sp1/3/4↓, DNAdam↑, TOP1↓, TumMeta↓, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, LDHA↓, p‑PDK1↓, PDK1↓, ECAR↓, OCR↓, Hif1a↓, STAT3↓,
5683- BML,    Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
- in-vitro, NA, NA
COX2/PTGS2↓, MAPK↓, NF-kB↓, TumMeta↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MAPK↓, ERK↓, Akt↓, TumVol↓,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, NA, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumMeta↓, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, Hif1a↓, Wnt/(β-catenin)↓, AXIN1↑, TumVol↓, TumW↓,
4477- Chit,    Recent Advances in Chitosan and its Derivatives in Cancer Treatment
- Review, NA, NA
*BioAv↑, AntiTum↑, eff↑, TumCG↓, angioG↓, TumMeta↓, eff↑, *toxicity↓, other↝,
2974- CUR,    Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vitro, CRC, HCT15 - in-vitro, CRC, COLO205 - in-vitro, CRC, SW-620 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumCG↓, TumMeta↓, Sp1/3/4↓, HDAC4↓, FAK↓, CD24↓, E-cadherin↑, EMT↓, TumCP↓, NF-kB↓, AP-1↝, STAT3↓, P53?, β-catenin/ZEB1↓, NOTCH1↝, Hif1a↝, PPARα↝, Rho↓, MMP2↓, MMP9↓,
1503- EGCG,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
selectivity↑, DNMT1↓, RECK↑, MMPs↓, TumCI↓, angioG↓, TumMeta↓, HATs↓, IκB↑, NF-kB↓, IL6↓, COX2/PTGS2↓, NOS2↓, ac‑H3↑, ac‑H4↑, eff↑,
1969- GamB,    Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
AntiTum↑, TumCI↓, Apoptosis↑, ROS↑, Cyt‑c↑, Akt↓, mTOR↓, TumCG↓, TumMeta↓,
2880- HNK,    Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vivo, NA, NA
tumCV↓, E-cadherin↑, Snail↓, Slug↓, Vim↓, TumMeta↓, p‑eIF2α↑,
517- MF,  Rad,    Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis
- in-vivo, NA, MDA-MB-231
TumMeta↓, TumCG↓,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,
2341- QC,    Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
MMP2↓, MMP9↓, VEGF↓, Glycolysis↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, TumAuto↑, Akt↓, mTOR↓, TumMeta↓, MMP3↓, eff↓, GlucoseCon↓, lactateProd↓, TumAuto↑, LC3B-II↑,
3418- TQ,    Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome
- in-vitro, Melanoma, A375 - in-vivo, NA, NA
TumMeta↓, TumCMig↓, NLRP3↓, Casp1↓, IL1β↓, IL18↓, ROS↓, NF-kB↓,
2414- β‐Ele,    Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumMeta↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, EGFR↓, GLUT1↓, LDHA↓, ECAR↓, OCR↓,

Showing Research Papers: 1 to 17 of 17

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 17

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

PARK2↑, 1,   ROS↓, 1,   ROS↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   OCR↓, 2,   PINK1↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 1,   ECAR↓, 2,   GlucoseCon↓, 2,   Glycolysis↓, 4,   lactateProd↓, 4,   LDHA↓, 3,   PDK1↓, 1,   p‑PDK1↓, 1,   PKM2↓, 2,   PPARα↝, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Apoptosis↑, 3,   BAX↑, 3,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp1↓, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 1,   DR4↑, 1,   FADD↑, 1,   FasL↑, 1,   MAPK↓, 2,   Mcl-1↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

p‑eIF2α↑, 2,   ER Stress↑, 1,   GRP78/BiP↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3B-II↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   DNMT1↓, 1,   P53?, 1,   P53↑, 2,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

AXIN1↑, 1,   BMI1↓, 1,   CD24↓, 1,   EMT↓, 3,   ERK↓, 1,   HDAC↓, 1,   HDAC4↓, 1,   mTOR↓, 2,   mTOR↑, 1,   NOTCH1↝, 1,   PI3K↓, 1,   PTEN↑, 1,   STAT3↓, 2,   TOP1↓, 1,   TumCG↓, 6,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↝, 1,   E-cadherin↑, 5,   FAK↓, 1,   miR-139-5p↑, 1,   MMP2↓, 3,   MMP3↓, 1,   MMP9↓, 4,   MMPs↓, 2,   N-cadherin↓, 3,   RECK↑, 1,   Rho↓, 1,   Slug↓, 1,   Snail↓, 3,   TIMP2↑, 1,   TumCI?, 1,   TumCI↓, 7,   TumCMig↓, 6,   TumCP↓, 3,   TumMeta↓, 17,   Vim↓, 4,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   angioG↑, 1,   EGFR↓, 2,   Hif1a↓, 3,   Hif1a↝, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 3,   CXCR2↓, 1,   CXCR4↓, 1,   IKKα↓, 1,   IL18↓, 1,   IL1β↓, 1,   IL6↓, 1,   IκB↑, 1,   NF-kB↓, 5,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 2,   eff↑, 3,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CTC↓, 1,   EGFR↓, 2,   IL6↓, 1,   NOS2↓, 1,   XIST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 3,   chemoPv↑, 1,   TumVol↓, 2,   TumW↓, 1,  
Total Targets: 123

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: TumMeta, Cancer Metastasis
1 Silver-NanoParticles
1 Artemisinin
1 Aspirin
1 Betulinic acid
1 Bromelain
1 Butyrate
1 Cannabidiol
1 chitosan
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 Gambogic Acid
1 Honokiol
1 Magnetic Fields
1 Radiotherapy/Radiation
1 Nimbolide
1 Quercetin
1 Thymoquinone
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:604  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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