LOX1 Cancer Research Results

LOX1, Lectin-like oxidized low-density lipoprotein receptor 1: Click to Expand ⟱
Source:
Type:
LOX-1 (Lectin-like oxidized low-density lipoprotein receptor 1) is a protein that has been implicated in various diseases, including cancer. Research has shown that LOX-1 is overexpressed in several types of cancer, including breast, lung, colon, and prostate cancer.

LOX-1 is involved in the regulation of cell proliferation, apoptosis (cell death), and angiogenesis (the formation of new blood vessels). In cancer, LOX-1 can promote tumor growth and metastasis by:

Enhancing cell proliferation and survival
Inhibiting apoptosis
Promoting angiogenesis
Facilitating the migration and invasion of cancer cells
Studies have also shown that LOX-1 can interact with other molecules involved in cancer progression, such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs).

Inhibiting LOX-1 has been proposed as a potential therapeutic strategy for cancer treatment.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, NA, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   Prx↑, 1,   ROS↓, 1,   SOD↑, 1,  

Migration ⓘ

AP-1↓, 1,   MMP9↓, 1,   TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

LOX1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 1,   IL10↑, 1,   IL1β↓, 1,   IL4↑, 1,   IL8↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  
Total Targets: 23

Scientific Paper Hit Count for: LOX1, Lectin-like oxidized low-density lipoprotein receptor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:680  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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