Risk Cancer Research Results

Risk, Risk: Click to Expand ⟱
Source:
Type:
Risk: by definition reduces risk of disease or cancer.
Down Target direction of risk indicates lower cancer risk.
ChemoPreventive also mean lower cancer risk. But for Chemopreventive an up arrow indicates more preventive. 
Cancer Risk Impact Score (CRIS)
CRIS scale:
–5 = very strong risk reduction
–4 = strong risk reduction
–3 = moderate risk reduction
–2 = modest risk reduction
–1 = weak / context-dependent
0 = neutral




CRIS Exposure / Compound Evidence Cancers Notes




-5 Exercise (overall)
VStrong Hum BC, CRC, Endo, PCa, Liv






-5 Aerobic + resistance VStrong Hum Broad inc + mort






-4 Aerobic exercise (mod–vig) VStrong Hum BC, CRC, Endo






-4 Resistance training (alone) Strong Hum BC, CRC






-3 High-intensity interval training Mod–Strong Hum BC, CRC






-2 NEAT / low-intensity activity Moderate Hum CRC






-5 Cruciferous vegetable pattern Strong Hum Lung, CRC, BC, PCa






-5 Sunlight exposure (physiologic) Strong Hum CRC, BC, PCa






-4 Fasting (metabolic pattern)
Strong Mech + Hum BC, CRC, PCa 






-4 Curcumin
Hum + Pre GI, BC, PCa






-4 Sulforaphane
Hum + Pre Lung, CRC, BC






-4 PEITC
Hum + Pre Lung, CRC, PCa






-4 EGCG (tea matrix)
Strong Hum GI, PCa, BC






-4 Lycopene
Strong Hum PCa






-4 Apigenin
Pre + Diet Hum BC, PCa, CRC 






-4 Luteolin
Pre + Diet Hum Lung, CRC, BC 






-4 Kaempferol
Diet Hum Ov, Panc, Lung






-4 Fisetin
Pre + Early Hum CRC, PCa, Mel






-4 Ellagic acid → Urolithin A
Hum (microbiome) CRC, PCa, BC






-3 Omega-3 (EPA/DHA)
Strong Hum CRC, BC






-3 Vitamin D3 (supp)
Obs + RCT CRC, BC






-3 Garlic (allicin)
Mod Hum GI






-3 Mushroom beta-glucans
Hum adjunct GI, BC






-3 Melatonin
Hum + Mech BC, PCa






-3 Coffee (whole)
Strong Hum Liv, Endo






-2 Quercetin
Limited Hum Lung, CRC






-2 Resveratrol
Limited Hum CRC, BC






-2 I3C / DIM
Mod Hum BC, Cerv






-2 Thymoquinone
Early Hum BC, CRC






-2 Beta-carotene (food)
Hum Lung






-1 Vitamin K2 (MK-4/7)
Limited Hum Liv, PCa






-1 Boron
Obs PCa, Lung






0 Vitamin C (oral)
Strong Hum —






0 Genistein (soy)
Strong Hum BC, PCa






0 Selenium (diet)
Mixed Hum PCa






0 Capsaicin
Mixed Gastric






+2 Vitamin E (alpha only)
Strong RCT PCa






+2 Green tea extract (high-dose)
Case reports Liv






+4 Beta-carotene (supplement)
Strong RCT Lung (smokers)






+5 Alcohol (ethanol)
Strong Hum BC, Liv, Eso







Evidence
Hum        human data
VStrong    very strong
Strong     strong
Mod        moderate
Obs        observational
Pre        preclinical
RCT        randomized controlled trial
Mech       mechanistic
Adjunct    adjunct clinical use


NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
546- AL,    Effects of garlic intake on cancer: a systematic review of randomized clinical trials and cohort studies
- Review, NA, NA
Risk↓, TumVol↓,
547- AL,    Garlic and Cancer: A Critical Review of the Epidemiologic Literature
- Review, NA, NA
Risk↓,
548- AL,    Aged Garlic and Cancer: A Systematic Review
- Review, NA, NA
Risk↓,
5412- ASA,    Clinical Pharmacology of Aspirin
- Review, NA, NA
*COX1↓, *COX2↓, *cardioP↑, *BioAv↑, *BioAv↝, *Half-Life↓, Risk↓, *other↑, *AntiAg↑,
701- Bor,    Dietary boron intake and prostate cancer risk
- Analysis, NA, NA
Risk↓,
702- Bor,  GEN,  SeMet,  Rad,    Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)
- Analysis, NA, NA
Risk↓, TumCMig↓, Bcl-2↓,
754- Bor,  HRT,    Dietary Boron and Hormone Replacement Therapy as Risk Factors for Lung Cancer in Women
- Analysis, NA, NA
Risk↓,
747- Bor,    Growing Evidence for Human Health Benefits of Boron
- Review, NA, NA
TumCG↓, Risk↓,
712- Bor,    Boron concentrations in selected foods from borate-producing regions in Turkey
- Analysis, NA, NA
Risk↓,
713- Bor,    Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells
- Analysis, NA, NA
Risk↓,
714- Bor,    Dietary Boron and Hormone Replacement Therapy as Risk Factors for Lung Cancer in Women
- Analysis, NA, NA
Risk↓,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
2144- Ex,    Physical activity, hormone replacement therapy and breast cancer risk: A meta-analysis of prospective studies
- Analysis, NA, NA
Risk↓, Dose?, eff↑,
1789- LEC,    Risk.33.aspx">Lecithin Supplements and Breast Cancer Risk
- Analysis, NA, NA
AntiCan↑, Risk↓,
1786- MEL,    What is known about melatonin, chemotherapy and altered gene expression in breast cancer (Review)
- Review, NA, NA
AntiTum↑, Risk↓, ChemoSen↑,
769- Mg,    Magnesium and cancer: more questions than answers
- Review, NA, NA
Risk↓,
770- Mg,    Magnesium and cancer: a dangerous liason
- Analysis, NA, NA
Risk↓,
784- Mg,    Direct and indirect associations between dietary magnesium intake and breast cancer risk
- Analysis, NA, NA
Risk↓, CRP↓,
785- Mg,    Magnesium: The overlooked electrolyte in blood cancers?
- Analysis, NA, NA
Risk↓,
2142- Se,    A U-shaped association between selenium intake and cancer risk
- Review, NA, NA
*Risk↝, Dose↝, *Risk↓,
4485- Se,    Selenium stimulates the antitumour immunity: Insights to future research
- Review, NA, NA
*antiOx↑, chemoPv↑, ROS↑, Imm↑, selenoP↑, *IL2↑, *IL4↑, *TNF-α↓, *TGF-β↓, *EMT↓, Risk↓, *GPx↑, *TrxR↑,
4491- SeNPs,  Chit,  VitC,    Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
- Study, NA, NA
*ROS↓, *selenoP↑, *antiOx↑, *Inflam↓, *Risk↓, *toxicity↓, AntiTum↑, Dose↝,
4309- VitK2,    Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases
- Review, NA, NA
*Apoptosis↓, *ROS↓, *antiOx↑, *cognitive↑, *memory↑, *Risk↓, *p‑tau↓,

Showing Research Papers: 1 to 23 of 23

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 23

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↓, 1,   ROS↑, 3,   selenoP↑, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Bcl-2↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   mTOR↓, 1,   PI3K↑, 1,   TumCG↓, 1,  

Migration ⓘ

TumCMig↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 1,   Imm↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose?, 1,   Dose↝, 2,   eff↑, 1,   eff↝, 1,  

Clinical Biomarkers ⓘ

CRP↓, 1,   GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 2,   chemoPv↑, 1,   OS↑, 1,   Risk↓, 20,   TumVol↓, 1,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   GPx↑, 1,   ROS↓, 2,   selenoP↑, 1,   TrxR↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

DNA Damage & Repair ⓘ

DNArepair↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

AntiAg↑, 1,   TGF-β↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 1,   IL2↑, 1,   IL4↑, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   Half-Life↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 1,   memory↑, 1,   Risk↓, 3,   Risk↝, 1,   toxicity↓, 1,  
Total Targets: 27

Scientific Paper Hit Count for: Risk, Risk
7 Boron
4 Magnesium
3 Allicin (mainly Garlic)
2 Selenium
1 Aspirin -acetylsalicylic acid
1 Genistein (soy isoflavone)
1 selenomethionine
1 Radiotherapy/Radiation
1 Hormone replacement therapy
1 diet FMD Fasting Mimicking Diet
1 Exercise
1 Lecithin
1 Melatonin
1 Selenium NanoParticles
1 chitosan
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:785  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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