SLC12A5 Cancer Research Results

SLC12A5, SLC12A5: Click to Expand ⟱

Source:

Type:

SLC12A5 is a gene that encodes a protein called KCC2, which is a potassium-chloride cotransporter. This protein plays a crucial role in maintaining the balance of potassium and chloride ions in cells, particularly in neurons.
SLC12A5 has been found to be overexpressed in glioblastoma, breast, lung, CRC.
SLC12A5 has been found to promote cell proliferation in cancer cells.

NA, Not Available: Click to Expand ⟱

none (reserved)

Scientific Papers found: Click to Expand⟱

2706-

BBR,

Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake

in-vitro,

HCC,

Hep3B

 50, 75, 100 and 125 μM

in-vitro,

HCC,

Bel-7402

in-vivo,

NA,

TumCP↓, glut↓, SLC12A5↓, cMyc↓, GLS↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1, GLS↓, 1, glut↓, 1,

Migration ⓘ

TumCP↓, 1,

Barriers & Transport ⓘ

SLC12A5↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: SLC12A5, SLC12A5

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells