CAIX Cancer Research Results

CAIX, Carbonic Anhydrase IX: Click to Expand ⟱
Source:
Type:
CAIX (Carbonic Anhydrase IX) is a transmembrane enzyme that plays a crucial role in maintaining the pH balance in cells and their surroundings. In the context of cancer, CAIX has been found to be overexpressed in various types of tumors.
CAIX is overexpressed in cancer cells compared to normal cells. This overexpression is thought to contribute to the increased ability of cancer cells to survive and grow in hypoxic environments.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
946- Nimb,    Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis
- in-vivo, NA, NA
Apoptosis↑, Bcl-2↓, P53↑, cl‑Casp3↑, Cyt‑c↑, ROS↑, SOD↓, Catalase↓, Glycolysis↓, GLUT3↓, LDHA↓, MCT1↓, NHE1↓, ATPase↓, CAIX↓,
1509- SFN,    Combination therapy in combating cancer
- Review, NA, NA
NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, eff↑, PSA↓, P53↑, Hif1a↓, CAIX↓, chemoR↓, 5HT↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   NRF2↑, 1,   ROS↑, 1,   SOD↓, 1,  

Core Metabolism/Glycolysis ⓘ

CAIX↓, 2,   Glycolysis↓, 1,   LDHA↓, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   Cyt‑c↑, 1,   MCT1↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

ATPase↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT3↓, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

PSA↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Drug Metabolism & Resistance ⓘ

chemoR↓, 1,   eff↑, 2,  

Clinical Biomarkers ⓘ

PSA↓, 1,  

Functional Outcomes ⓘ

ChemoSideEff↓, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CAIX, Carbonic Anhydrase IX
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:929  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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