MCP1 Cancer Research Results

MCP1, CCL2,monocyte chemotactic protein-1: Click to Expand ⟱

Source:

Type:

MCP-1 (Monocyte Chemoattractant Protein-1, also known as CCL2)
MCP-1/CCL2 is a chemokine involved in recruiting monocytes, memory T cells, and dendritic cells to sites of inflammation.
– It plays a key role in mediating immune cell trafficking, inflammation, and tissue remodeling. MCP-1 is pivotal in inflammatory responses and can modulate immune cell infiltration into tissues.
– It also influences the polarization of macrophages, which may adopt pro-inflammatory (M1) or anti-inflammatory/pro-tumoral (M2) roles.

Many cancers (such as breast, prostate, ovarian, lung, and colon cancers) exhibit increased levels of MCP-1.
– Both tumor cells and associated stromal cells (e.g., cancer-associated fibroblasts, infiltrating immune cells) can produce MCP-1, contributing to an inflammatory milieu.

• Inducers of MCP-1:
– Hypoxia, oncogenic pathways, and cytokine-rich environments (e.g., IL-1β, TNF-α) can drive increased MCP-1 expression.
– This upregulation often correlates with an ongoing inflammatory response in the tumor microenvironment.

NA, Not Available: Click to Expand ⟱

none (reserved)

Scientific Papers found: Click to Expand⟱

3689-

Ash,

Ashwagandha attenuates TNF-α- and LPS-induced NF-κB activation and CCL2 and CCL5 gene expression in NRK-52E cells

in-vitro,

NA,

NRK52E

*RenoP↑, *NF-kB↓, *MCP1↓, *RANTES↓,

2614-

Ba,

Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

Review,

NA,

*toxicity↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *MCP1↓, *hepatoP↑, *neuroP↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 1, ROS↓, 1,

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1, MCP1↓, 2, NF-kB↓, 2, RANTES↓, 1,

Functional Outcomes ⓘ

hepatoP↑, 1, neuroP↑, 1, RenoP↑, 1, toxicity↓, 1,
Total Targets: 10

Scientific Paper Hit Count for: MCP1, CCL2,monocyte chemotactic protein-1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells