ASC Cancer Research Results

ASC, Apoptosis-associated Speck-like protein containing a CARD: Click to Expand ⟱
Source:
Type:
ASC (Apoptosis-associated Speck-like protein containing a CARD, also known as PYCARD) – ASC is a key adaptor molecule in the assembly of inflammasomes—a multiprotein complex that activates caspase-1.
– Beyond its inflammasome functions, ASC has been implicated in mediating apoptosis.

– In some cancers, ASC expression is downregulated, which may impair inflammasome assembly and promote immune evasion, whereas in other tumor types, elevated ASC has been reported, sometimes reflecting a heightened local inflammatory state.
– Studies indicate that reduced ASC expression in certain tumor types (for example, melanoma or colon cancer) can correlate with decreased inflammasome activity, potentially leading to immune evasion and a more aggressive tumor phenotype.
– Conversely, in some cancers an upregulation or persistent activation of ASC-containing inflammasomes has been linked to a pro-inflammatory milieu that might drive tumor progression and metastasis.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
1092- BBR,    Berberine as a Potential Anticancer Agent: A Comprehensive Review
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumAuto↑, TumCI↓, IL1↓, IL6↓, TNF-α↓, LDH↓, P2X7↓, proCasp1↓, Casp1↓, ASC↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

LDH↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp1↓, 1,   proCasp1↓, 1,   P2X7↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

TumCI↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   IL1↓, 1,   IL6↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,   LDH↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ASC, Apoptosis-associated Speck-like protein containing a CARD
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:996  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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