PSD95 Cancer Research Results

PSD95, Postsynaptic density protein 95: Click to Expand ⟱
Source:
Type:
PSD95 (Postsynaptic density protein 95) is a critical scaffolding protein in excitatory synapses, particularly abundant in the postsynaptic density (PSD) of neurons. It plays a key role in synaptic signaling and plasticity, including anchoring NMDA receptors and organizing signaling complexes.
-↓ PSD95 levels in hippocampus and cortex in AD patients and models.
-Loss of PSD95 impairs synaptic plasticity (e.g., LTP) and memory formation
-Hyperphosphorylated tau disrupts PSD95-mediated signaling.
-Agents that preserve or restore PSD95 levels show cognitive benefits in models
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
3797- CUR,    Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice
- in-vitro, NA, NA
*cognitive↑, *BDNF↑, *PSD95↑, *memory↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, NA, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, NA, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,
4227- Lyco,    Lycopene Alleviates Depression-Like Behavior in Chronic Social Defeat Stress-Induced Mice by Promoting Synaptic Plasticity via the BDNF-TrkB Pathway
- in-vivo, NA, NA
*BDNF↑, *TrkB↑, *PSD95↑,
3798- RES,    Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure
- in-vivo, NA, NA
*SIRT1↑, *BDNF↑, *PSD95↑, *memory↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GPx↑, 1,   Iron↓, 2,   MDA↓, 1,   ROS↓, 2,   SOD↑, 1,  

Metal & Cofactor Biology ⓘ

FTL↓, 1,   TfR1/CD71↓, 2,  

Core Metabolism/Glycolysis ⓘ

CREB↑, 1,   NADPH↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Bax:Bcl2↓, 1,   Casp3↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,  

Migration ⓘ

PKA↑, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 5,   PSD95↑, 5,   TrkB↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 3,   memory↑, 2,   neuroP↑, 2,  
Total Targets: 21

Scientific Paper Hit Count for: PSD95, Postsynaptic density protein 95
2 Huperzine A/Huperzia serrata
1 Curcumin
1 Lycopene
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:1359  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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