IKKα Cancer Research Results

IKKα, IκB kinase alpha): Click to Expand ⟱
Source:
Type:
Expression of genes involved in nuclear factor (NF)-kappaB activation (NF-κB, IKKα) IKKα (IκB kinase alpha) is a critical component of the NF-κB signaling pathway, which plays a significant role in regulating immune responses, inflammation, and cell survival.
The NF-κB pathway, activated by IKKα, can lead to the production of pro-Inhibitors of the NF-κB pathway, including those targeting IKKα, are being investigated for their potential to treat various cancers.inflammatory cytokines that may create a tumor-promoting microenvironment.
NA, Not Available: Click to Expand ⟱
none (reserved)
Scientific Papers found: Click to Expand⟱
2599- Ba,    Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
TumCP↓, Apoptosis↑, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IKKα↓, IKKα↑, PI3K↓, MMP↓, TumAuto↑, TumVol↓, TumW↓,
2385- MET,    Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model
- in-vitro, AD, H4 - in-vitro, NA, HEK293 - in-vivo, NA, NA - in-vitro, NA, SH-SY5Y
*HK2↓, *PKM2↓, *Dose↝, IKKα↑, memory↑, p‑Hsc70↑, APP↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,  

Protein Folding & ER Stress ⓘ

p‑Hsc70↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑mTOR↓, 1,   PI3K↓, 1,  

Migration ⓘ

APP↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

IKKα↑, 2,   p‑IKKα↓, 1,   NF-kB↓, 1,  

Functional Outcomes ⓘ

memory↑, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

HK2↓, 1,   PKM2↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  
Total Targets: 3

Scientific Paper Hit Count for: IKKα, IκB kinase alpha)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:0  Cells:%  prod#:%  Target#:156  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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