p27 Cancer Research Results
p27, p27kip1: Click to Expand ⟱
| Source: |
| Type: |
The cyclin-dependent kinase (Cdk) inhibitor p27 regulates cell proliferation, cell motility and apoptosis, and is inactivated through various means in many types of human cancer.
|
NA, Not Available: Click to Expand ⟱
Scientific Papers found: Click to Expand⟱
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, KDR/FLK-1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
ROS↑, ER Stress↑, Ca+2↑, MMPs↓, Cyt‑c↑, Casp3↑, ROS↑, DR5↑, ROS↑, BAX↑, Bcl-2↓, MMP↓, Casp3↑, Casp9↑, P53↑, p16↑, P21↑, p27↑, HDAC10↑, MDM2↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, p‑IκB↓, IκB↑, BAX↑, Bcl-2↓, ROS⇅, BNIP3↑, p38↑, 12LOX↓, Mcl-1↓, Wnt?, GLI2↓, AR↓, eff↑,
TumCCA↑, TP53↑, COX2↓, Bax:Bcl2↑, ROS↑, VEGFR2↓, Akt↓, ERK↓, MMP2↓, MMP9↓, IL8↑, P21↑, p27↑, E-cadherin↓, Fibronectin↓, cMyc↓,
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27↑, P21↑,
E7↓, E6↓, PI3K/Akt↓, P53↑, p27↑, P21↑, CDK2↓, mTOR↓, HIF-1↓, IGF-1↓, EGFR↓, ERK↓, VEGF↓,
| - |
in-vitro, |
PC, |
NA |
|
|
|
- |
in-vivo, |
NA, |
NA |
|
|
|
Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE/CCNE↓, P21↑, p27↑,
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
Showing Research Papers: 1 to 7 of 7
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
Ferroptosis↑, 1, ROS↓, 1, ROS↑, 5, ROS⇅, 1,
Mitochondria & Bioenergetics ⓘ
ATP↓, 1, MMP↓, 2,
Core Metabolism/Glycolysis ⓘ
12LOX↓, 1, cMyc↓, 2, PI3K/Akt↓, 1, SIRT1↓, 1, SREBP1↓, 1,
Cell Death ⓘ
Akt↓, 4, p‑Akt↓, 1, Apoptosis↑, 2, BAX↑, 3, Bax:Bcl2↑, 1, Bcl-2↓, 3, Casp↑, 2, Casp3↑, 2, Casp9↑, 1, p‑Chk2↑, 1, Cyt‑c↑, 2, DR5↑, 1, Ferroptosis↑, 1, HGF/c-Met↓, 1, MAPK↓, 1, Mcl-1↓, 1, MDM2↓, 1, oncosis↑, 1, p27↑, 7, p38↑, 1, survivin↓, 1, Telomerase↓, 1,
Transcription & Epigenetics ⓘ
HATs↑, 1,
Protein Folding & ER Stress ⓘ
ER Stress↑, 1,
Autophagy & Lysosomes ⓘ
BNIP3↑, 1, TumAuto↑, 1,
DNA Damage & Repair ⓘ
p‑ATM↑, 1, p‑ATR↑, 1, p‑CHK1↑, 1, DNAdam↑, 1, HR↓, 1, p16↑, 2, P53↑, 2, PARP↑, 1, PCNA↓, 1, RAD51↓, 1, TP53↑, 1,
Cell Cycle & Senescence ⓘ
CDK2↓, 2, CDK4↓, 1, cycD1/CCND1↓, 1, cycE/CCNE↓, 1, cycE1↓, 1, P21↑, 6, TumCCA↑, 4,
Proliferation, Differentiation & Cell State ⓘ
CD44↓, 1, cMET↓, 1, EMT↓, 1, ERK↓, 5, Gli1↓, 1, HDAC↓, 1, HDAC10↑, 1, IGF-1↓, 1, IGFBP3↑, 1, mTOR↓, 2, p‑mTOR↓, 1, NOTCH↓, 1, PI3K↓, 3, STAT3↓, 2, TumCG↓, 1, Wnt?, 1, Wnt↓, 1, Wnt/(β-catenin)↓, 1,
Migration ⓘ
CA↓, 1, Ca+2↑, 2, CDK4/6↓, 1, E-cadherin↓, 1, E-cadherin↑, 1, FAK↓, 1, Fibronectin↓, 1, GLI2↓, 1, ITGB1↑, 1, Ki-67↓, 1, miR-203↑, 1, MMP2↓, 3, MMP9↓, 2, MMPs↓, 1, NCAM↑, 1, PDGF↓, 1, TGF-β↓, 2, TIMP2↑, 1, TumCI↓, 1, TumCMig↓, 2, uPA↓, 1, Vim↓, 1, Zeb1↓, 1,
Angiogenesis & Vasculature ⓘ
angioG↓, 1, EGFR↓, 3, HIF-1↓, 1, Hif1a↓, 2, KDR/FLK-1↓, 1, NO↓, 1, VEGF↓, 4, VEGFR2↓, 1,
Barriers & Transport ⓘ
NHE1↓, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 2, IL1↓, 2, IL6↓, 1, IL8↑, 1, IκB↑, 1, p‑IκB↓, 1, MIP2↓, 1, NF-kB↓, 4, PD-L1↓, 1, PGE2↓, 2, PSA↓, 1, TNF-α↓, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 3,
Drug Metabolism & Resistance ⓘ
BioAv↓, 3, Dose↝, 1, eff↑, 1, eff↝, 1, Half-Life↓, 1, Half-Life↝, 1, selectivity↑, 1,
Clinical Biomarkers ⓘ
AR↓, 3, E6↓, 1, E7↓, 1, EGFR↓, 3, IL6↓, 1, Ki-67↓, 1, PD-L1↓, 1, PSA↓, 1, TP53↑, 1,
Functional Outcomes ⓘ
AntiCan↑, 1, cardioP↑, 1, chemoP↑, 1, hepatoP↑, 1, toxicity↝, 1, toxicity∅, 1,
Total Targets: 140
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 1,
Core Metabolism/Glycolysis ⓘ
SIRT1↑, 1,
Migration ⓘ
TIMP1↓, 1,
Immune & Inflammatory Signaling ⓘ
IL8↓, 1, Inflam↓, 1,
Total Targets: 5
Scientific Paper Hit Count for: p27, p27kip1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:0 Cells:% prod#:% Target#:468 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
Home Page